RESUMEN
The diagnosis of bullae can be a challenge. The proper diagnosis and prompt treatment is mandatory because most of these diseases are associated with a significant degree of morbidity. The authors present the case of a 76-year-old woman admitted for treatment of anasarca. She also exhibited a bullous eruption localized to the right upper limb.
Asunto(s)
Edema/complicaciones , Enfermedades Cutáneas Vesiculoampollosas/patología , Anciano , Femenino , Humanos , Piel/patología , Enfermedades Cutáneas Vesiculoampollosas/diagnóstico , Enfermedades Cutáneas Vesiculoampollosas/etiologíaRESUMEN
Extraocular sebaceous carcinoma (ESC) is a rare, aggressive malignant tumor that originates from the adnexal epithelium of the sebaceous gland. We present herein one of the largest cases reported in the literature until now. We also review briefly the relevant aspects including clinical presentation, differential diagnosis, histopathological features, inmunohistochemical profile, and therapeutic options.
Asunto(s)
Adenocarcinoma Sebáceo/patología , Neoplasias de las Glándulas Sebáceas/patología , Pared Torácica , Adenocarcinoma Sebáceo/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de las Glándulas Sebáceas/diagnósticoRESUMEN
Poroma is a rare, benign, appendage tumor. Clinically, it presents as a solitary, slowly growing tumor situated mostly on the palms and soles of adults. Occasionally, poroma mimics malignant tumors. Histological examination reveals aggregations of poroid cells extending into the epidermis. Dermoscopy may be useful in some cases. Treatment is by surgical excision. We report a case of a typical clinical and histopathological presentation in a 26-year-old woman and emphasize the importance of this lesion in the differential diagnosis of other tumors on the palms and soles.
Asunto(s)
Poroma/diagnóstico , Neoplasias de las Glándulas Sudoríparas/diagnóstico , Adulto , Femenino , Humanos , Poroma/patología , Neoplasias de las Glándulas Sudoríparas/patologíaRESUMEN
In Brazil, without considering the non-melanoma skin tumors, bladder cancer in men is the eighth most common, and the urothelial carcinoma or transitional cell carcinoma is the most common among these. Cutaneous metastases from urothelial neoplasms appear as single or multiple erythematous, infiltrated nodules or plaques, and like other cases of distant disease, it is indicative of poor prognosis. The invasive urothelial carcinoma is recognized for its ability to present divergent differentiation and morphological variants. The sarcomatoid urothelial carcinoma is a rare cancer that consists of two different components: one composed of epithelial tissue and the other with sarcomatoid features of mesenchymal origin. The authors describe a case of cutaneous metastasis of sarcomatoid urothelial carcinoma in a 63-year-old male patient.
Asunto(s)
Carcinoma de Células Transicionales/patología , Carcinosarcoma/patología , Neoplasias Cutáneas/patología , Neoplasias de la Vejiga Urinaria/patología , Resultado Fatal , Humanos , Masculino , Persona de Mediana Edad , Invasividad Neoplásica , Piel/patología , Urotelio/patologíaRESUMEN
Although subungual squamous cell carcinoma is rare, it is the most common primary malignant neoplasms in this location. The higher incidence occurs in the fingernails, but involvement of the toenails is also possible. Subungual squamous cell carcinoma often looks like other more common benign lesions, such as fungal infection, onychomycosis, or viral wart. These factors, together with a general lack of awareness of this disease among physicians, often result in delayed diagnosis. Therefore, it is underdiagnosed, with few reports in the literature. The authors present a case of a man with a diagnosis of subungual squamous cell carcinoma in the hallux, without bone involvement, which was submitted to the appropriate surgical treatment.
Asunto(s)
Carcinoma de Células Escamosas/patología , Enfermedades de la Uña/patología , Neoplasias Cutáneas/patología , Anciano , Biopsia , Carcinoma de Células Escamosas/cirugía , Humanos , Masculino , Enfermedades de la Uña/cirugía , Neoplasias Cutáneas/cirugía , Dedos del Pie/patología , Resultado del TratamientoRESUMEN
Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.
Asunto(s)
Dapsona/efectos adversos , Antagonistas del Ácido Fólico/efectos adversos , Glucocorticoides/administración & dosificación , Pénfigo/tratamiento farmacológico , Prednisona/administración & dosificación , Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Quimioterapia Adyuvante , Dapsona/administración & dosificación , Relación Dosis-Respuesta a Droga , Femenino , Antagonistas del Ácido Fólico/administración & dosificación , Humanos , Hígado/efectos de los fármacos , Persona de Mediana Edad , Pénfigo/patología , Factores de Tiempo , Resultado del TratamientoRESUMEN
We report the case of a three-year-old child who, following long term treatment with topical corticosteroids and their associations for a case of ringworm on the face developed a form of folliculitis known as Majocchi's Granuloma. Treatment with oral Griseofulvin was successful.
Asunto(s)
Dermatosis Facial/patología , Granuloma/patología , Tiña/patología , Antifúngicos/uso terapéutico , Biopsia , Preescolar , Dermatosis Facial/tratamiento farmacológico , Femenino , Foliculitis/patología , Granuloma/tratamiento farmacológico , Griseofulvina/uso terapéutico , Humanos , Inmunocompetencia , Piel/patología , Tiña/tratamiento farmacológico , Resultado del TratamientoRESUMEN
Acroangiodermatitis is an angioproliferative disease usually related to chronic venous insufficiency, and it is considered a clinical and histological simulator of Kaposi's sarcoma (KS). Immunohistochemistry is the suitable method to differentiate between these two entities. It reveals the following immunostaining profile: immunopositivity with anti-CD34 antibody is restricted to the vascular endothelium in acroangiodermatitis, and diffuse in the KS (endothelial cells and perivascular spindle cells); immunopositivity with anti-HHV-8 only in KS cases. We report the case of an HIV seropositive patient without apparent vascular disease, who presented violaceous and brownish erythematous lesions on the feet, and whose histopathology and immunohistochemistry indicated the diagnosis of acroangiodermatitis.
Asunto(s)
Acrodermatitis/patología , Seropositividad para VIH/patología , Hepatitis C/patología , Sarcoma de Kaposi/patología , Sífilis/patología , Acrodermatitis/tratamiento farmacológico , Adulto , Coinfección/patología , Diagnóstico Diferencial , Humanos , Inmunohistoquímica , Masculino , Piel/patologíaRESUMEN
Over the last few centuries, the expansion of urbanization brought bats closer to urbanized areas, increasing the risk of accidents by bat bites. The morphology of bat bites can be varied, usually having an elliptical shape, about 0.5 cm along its greatest length, and the characteristic corkscrew bite pattern. The authors present the case of a patient who was repeatedly bitten by vampire bats for two months. A polymerase chain reaction was performed in the cutaneous nerves at the base of the hair follicles which showed negativity towards the rabies virus. The authors highlight the public health importance of this case, and discuss the morphological characteristics of these hematophagous bat bites.
Asunto(s)
Mordeduras y Picaduras/patología , Quirópteros , Piel/lesiones , Adulto , Animales , Biopsia , Brasil , Humanos , Masculino , Virus de la Rabia , Úlcera Cutánea/patologíaRESUMEN
Confluent and reticulated papillomatosis of Gougerot and Carteaud is a dermatosis that despite showing characteristic clinical signs is often poorly recognized and diagnosed. The authors present a case with extensive skin involvement, discuss its association with obesity and describe dermoscopic findings making the histopathological correlation.
Asunto(s)
Obesidad/complicaciones , Papiloma/patología , Neoplasias Cutáneas/patología , Adulto , Índice de Masa Corporal , Dermoscopía , Humanos , Masculino , Obesidad/terapia , Papiloma/etiología , Papiloma/terapia , Neoplasias Cutáneas/etiología , Neoplasias Cutáneas/terapia , Resultado del Tratamiento , Pérdida de PesoRESUMEN
Clinically and histopathologically paucibacillary leprosy shows similar features with initial morphea. In this case we report a 24 yr-old male patient who presented to our dermatology department with diagnosed paucibacillary leprosy by his local dermatologist, and confirmed by perineurovascular lymphocytic infiltrate in the histopathological exam. On physical examination we found new plaque lesions that were suggestive of morphea with alteration of sensitivity. A new biopsy was performed showing sclerotic superficial dermis with thickening of the collagen bundles in deep dermis and linear arrays lymphocytic infiltrate between the collagen bundles that confirm the diagnosis of morphea.
RESUMEN
Sebaceous carcinoma is a rare and aggressive skin tumor. It can be located in any area of the body, the most commonly involved area being the periorbital region. It does not entail a typical clinical presentation, which explains the often late diagnosis. The aim of this report is to outline the rarity of the disease and its atypical clinical description, since to this day, inguinal ulcers with clinical manifestation have not been reported. We present and discuss a case of sebaceous carcinoma with an unusual clinical presentation, in an elderly male patient. The precise approach to genital ulcers, as shown in this case, is a diagnostic challenge that requires a great deal of effort on the part of the clinician.
Asunto(s)
Carcinoma/patología , Conducto Inguinal/patología , Neoplasias de las Glándulas Sebáceas/patología , Úlcera Cutánea/patología , Biopsia , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana EdadRESUMEN
Tufted angioma is a rare acquired vascular tumor. It is characterized by painful purplish macules that may progress to plaques containing angiomatous papules. The condition is benign; however, it often affects extensive areas of the skin, leading to functional disability of the affected limb if painful. The present report describes a case of a tufted angioma associated with myofascial pain syndrome in which the predisposing element was the presence of this tumor since childhood. Pain at the site of the lesion affected muscle use and led to the onset of the associated syndrome. Complete relief from symptoms was achieved by blocking the trigger points of the affected limb with anesthesia.
Asunto(s)
Hemangioma/complicaciones , Síndromes del Dolor Miofascial/etiología , Neoplasias Cutáneas/complicaciones , Adulto , Femenino , Humanos , Síndromes del Dolor Miofascial/fisiopatología , Puntos Disparadores/fisiopatología , Adulto JovenRESUMEN
Abstract In Brazil, without considering the non-melanoma skin tumors, bladder cancer in men is the eighth most common, and the urothelial carcinoma or transitional cell carcinoma is the most common among these. Cutaneous metastases from urothelial neoplasms appear as single or multiple erythematous, infiltrated nodules or plaques, and like other cases of distant disease, it is indicative of poor prognosis. The invasive urothelial carcinoma is recognized for its ability to present divergent differentiation and morphological variants. The sarcomatoid urothelial carcinoma is a rare cancer that consists of two different components: one composed of epithelial tissue and the other with sarcomatoid features of mesenchymal origin. The authors describe a case of cutaneous metastasis of sarcomatoid urothelial carcinoma in a 63-year-old male patient.
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Carcinoma de Células Transicionales/patología , Carcinosarcoma/patología , Neoplasias Cutáneas/patología , Neoplasias de la Vejiga Urinaria/patología , Resultado Fatal , Invasividad Neoplásica , Piel/patología , Urotelio/patologíaRESUMEN
Abstract Although subungual squamous cell carcinoma is rare, it is the most common primary malignant neoplasms in this location. The higher incidence occurs in the fingernails, but involvement of the toenails is also possible. Subungual squamous cell carcinoma often looks like other more common benign lesions, such as fungal infection, onychomycosis, or viral wart. These factors, together with a general lack of awareness of this disease among physicians, often result in delayed diagnosis. Therefore, it is underdiagnosed, with few reports in the literature. The authors present a case of a man with a diagnosis of subungual squamous cell carcinoma in the hallux, without bone involvement, which was submitted to the appropriate surgical treatment.
Asunto(s)
Humanos , Masculino , Anciano , Neoplasias Cutáneas/patología , Carcinoma de Células Escamosas/patología , Enfermedades de la Uña/patología , Neoplasias Cutáneas/cirugía , Biopsia , Carcinoma de Células Escamosas/cirugía , Dedos del Pie/patología , Resultado del Tratamiento , Enfermedades de la Uña/cirugíaRESUMEN
Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. This drug is not without side effects and its use requires clinical and laboratory control. We present a patient with PV initially managed with suboptimal dose of prednisone, evolving into drug-induced hepatitis after introduction of dapsone.
.Asunto(s)
Femenino , Humanos , Persona de Mediana Edad , Dapsona/efectos adversos , Antagonistas del Ácido Fólico/efectos adversos , Glucocorticoides/administración & dosificación , Pénfigo/tratamiento farmacológico , Prednisona/administración & dosificación , Quimioterapia Adyuvante , Relación Dosis-Respuesta a Droga , Dapsona/administración & dosificación , Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Antagonistas del Ácido Fólico/administración & dosificación , Hígado/efectos de los fármacos , Pénfigo/patología , Factores de Tiempo , Resultado del TratamientoRESUMEN
We report the case of a three-year-old child who, following long term treatment with topical corticosteroids and their associations for a case of ringworm on the face developed a form of folliculitis known as Majocchi's Granuloma. Treatment with oral Griseofulvin was successful.
Asunto(s)
Humanos , Femenino , Preescolar , Tiña/patología , Dermatosis Facial/patología , Granuloma/patología , Piel/patología , Tiña/tratamiento farmacológico , Biopsia , Resultado del Tratamiento , Dermatosis Facial/tratamiento farmacológico , Foliculitis/patología , Granuloma/tratamiento farmacológico , Griseofulvina/uso terapéutico , Inmunocompetencia , Antifúngicos/uso terapéuticoRESUMEN
Acroangiodermatitis is an angioproliferative disease usually related to chronic venous insufficiency, and it is considered a clinical and histological simulator of Kaposi's sarcoma (KS). Immunohistochemistry is the suitable method to differentiate between these two entities. It reveals the following immunostaining profile: immunopositivity with anti-CD34 antibody is restricted to the vascular endothelium in acroangiodermatitis, and diffuse in the KS (endothelial cells and perivascular spindle cells); immunopositivity with anti-HHV-8 only in KS cases. We report the case of an HIV seropositive patient without apparent vascular disease, who presented violaceous and brownish erythematous lesions on the feet, and whose histopathology and immunohistochemistry indicated the diagnosis of acroangiodermatitis.
Asunto(s)
Adulto , Humanos , Masculino , Acrodermatitis/patología , Seropositividad para VIH/patología , Hepatitis C/patología , Sarcoma de Kaposi/patología , Sífilis/patología , Acrodermatitis/tratamiento farmacológico , Coinfección/patología , Diagnóstico Diferencial , Inmunohistoquímica , Piel/patologíaRESUMEN
Over the last few centuries, the expansion of urbanization brought bats closer to urbanized areas, increasing the risk of accidents by bat bites. The morphology of bat bites can be varied, usually having an elliptical shape, about 0.5 cm along its greatest length, and the characteristic corkscrew bite pattern. The authors present the case of a patient who was repeatedly bitten by vampire bats for two months. A polymerase chain reaction was performed in the cutaneous nerves at the base of the hair follicles which showed negativity towards the rabies virus. The authors highlight the public health importance of this case, and discuss the morphological characteristics of these hematophagous bat bites.
Asunto(s)
Adulto , Animales , Humanos , Masculino , Mordeduras y Picaduras/patología , Quirópteros , Piel/lesiones , Biopsia , Brasil , Virus de la Rabia , Úlcera Cutánea/patologíaRESUMEN
Confluent and reticulated papillomatosis of Gougerot and Carteaud is a dermatosis that despite showing characteristic clinical signs is often poorly recognized and diagnosed. The authors present a case with extensive skin involvement, discuss its association with obesity and describe dermoscopic findings making the histopathological correlation.