Detalles de la búsqueda
1.
In Vitro and In Silico of Cholinesterases Inhibition and In Vitro and In Vivo Anti-Melanoma Activity Investigations of Extracts Obtained from Selected Berberis Species.
Molecules
; 29(5)2024 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38474561
2.
Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties.
J Enzyme Inhib Med Chem
; 38(1): 192-202, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36345785
3.
Thiosemicarbazide Derivatives Targeting Human TopoIIα and IDO-1 as Small-Molecule Drug Candidates for Breast Cancer Treatment.
Int J Mol Sci
; 24(6)2023 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36982886
4.
Combined In Silico and In Vitro Analyses to Assess the Anticancer Potential of Thiazolidinedione-Thiosemicarbazone Hybrid Molecules.
Int J Mol Sci
; 24(24)2023 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38139350
5.
TZD-Based Hybrid Molecules Act as Dual Anti-Mycobacterium tuberculosis and Anti-Toxoplasma gondii Agents.
Int J Mol Sci
; 24(3)2023 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-36768392
6.
Determination of Selected Isoquinoline Alkaloids from Chelidonium majus, Mahonia aquifolium and Sanguinaria canadensis Extracts by Liquid Chromatography and Their In Vitro and In Vivo Cytotoxic Activity against Human Cancer Cells.
Int J Mol Sci
; 24(7)2023 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37047332
7.
Effect of Linker Elongation on the VGSC Affinity and Anticonvulsant Activity among 4-Alkyl-5-aryl-1,2,4-triazole-3-thione Derivatives.
Molecules
; 28(13)2023 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37446948
8.
Determination of Some Isoquinoline Alkaloids in Extracts Obtained from Selected Plants of the Ranunculaceae, Papaveraceae and Fumarioideae Families by Liquid Chromatography and In Vitro and In Vivo Investigations of Their Cytotoxic Activity.
Molecules
; 28(8)2023 Apr 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-37110737
9.
Inhibition of Toxoplasma gondii by 1,2,4-triazole-based compounds: marked improvement in selectivity relative to the standard therapy pyrimethamine and sulfadiazine.
J Enzyme Inhib Med Chem
; 37(1): 2621-2634, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36165032
10.
Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application.
Int J Mol Sci
; 23(12)2022 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-35743039
11.
Aloe arborescens: In Vitro Screening of Genotoxicity, Effective Inhibition of Enzyme Characteristics for Disease Etiology, and Microbiological Activity.
Molecules
; 27(7)2022 Apr 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35408722
12.
Determination of Cytotoxic Activity of Sanguinaria canadensis Extracts against Human Melanoma Cells and Comparison of Their Cytotoxicity with Cytotoxicity of Some Anticancer Drugs.
Molecules
; 26(6)2021 Mar 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-33804614
13.
Determination of Cytotoxic Activity of Selected Isoquinoline Alkaloids and Plant Extracts Obtained from Various Parts of Mahonia aquifolium Collected in Various Vegetation Seasons.
Molecules
; 26(4)2021 Feb 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33557343
14.
Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltage-gated sodium channels (VGSCs) as promising anticonvulsant drug candidates.
Bioorg Chem
; 94: 103355, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31662213
15.
1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy.
J Enzyme Inhib Med Chem
; 35(1): 993-1002, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32253957
16.
Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate.
Int J Med Sci
; 14(8): 741-749, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28824309
17.
Design, synthesis and biological evaluation of 4-benzoyl-1-dichlorobenzoylthiosemicarbazides as potent Gram-positive antibacterial agents.
J Enzyme Inhib Med Chem
; 31(3): 434-40, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-25897586
18.
Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles.
J Enzyme Inhib Med Chem
; 30(6): 1021-6, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25792499
19.
Determination of the primary molecular target of 1,2,4-triazole-ciprofloxacin hybrids.
Molecules
; 20(4): 6254-72, 2015 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25859782
20.
Studies on the anticonvulsant activity and influence on GABA-ergic neurotransmission of 1,2,4-triazole-3-thione- based compounds.
Molecules
; 19(8): 11279-99, 2014 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-25090118