RESUMEN
PURPOSE: To investigate the relation between PET-CT SUVmax value and prognostic factors in locally advanced breast cancer. METHODS: Data of 73 patients were retrospectively analyzed. Relations between SUVmax value, clinical stage, tumor grade and breast cancer molecular subtypes were analyzed by using one-way ANOVA and x(2) tests. Correlations between age, ki-67 scores and SUVmax were evaluated by using Pearson's correlation test. A p value <0.05 was considered statistically significant. RESULTS: Median SUVmax values for clinical stages 1, 2 and 3 were 5 (range 2.1-4.1), 10.6 (range 2.9-19.6), and 12.2 (range 3.2-23.3), respectively. Statistically significant difference was noticed between stage 1 and 2 (p=0.014) and stage 1 and 3 (p=0.001). Median SUVmax values of triple negative, luminal A, luminal B and non-luminal HER2 positive groups were 14.4 (range 6.6-23.3), 8.2 (range 2.1-18.2), 10.1 (range 3.5-19.6), and 14 (range 4.1-22.9), respectively. Statistically significant differences were noticed in SUVmax values between triple-negative and luminal A groups (p=0.005) and between non-luminal HER2 positive and luminal A groups (p=0.02). Median SUVmax values of grade 1, 2 and 3 were 5.7 (range 2.1-18.2), 9.5 (range 2.2-21.3), and 11.6 (range 3.5-23), respectively. Statistically significant difference was noticed only between SUVmax values of grade 1 and 3 (p=0.035). There was negative correlation between age and SUVmax value (r=-0.23, p=0.047) and positive correlation between ki-67 and SUVmax value (r=0.43, p=0.016). CONCLUSION: There were significant positive relations between PET-CT SUVmax value and clinical stage, tumor grade, and certain breast cancer molecular subtypes (triple-negative and non-luminal HER2 positive groups. Moreover, positive correlation was found between SUVmax value and ki-67 and negative correlation between SUVmax value and age.
Asunto(s)
Neoplasias de la Mama/diagnóstico por imagen , Tomografía de Emisión de Positrones , Adulto , Anciano , Neoplasias de la Mama/patología , Femenino , Humanos , Antígeno Ki-67/análisis , Antígeno Ki-67/química , Persona de Mediana Edad , Pronóstico , Receptor ErbB-2/análisis , Estudios Retrospectivos , Tomografía Computarizada por Rayos XRESUMEN
INTRODUCTION: Heart rate variability (HRV) is decreased in dialysis patients, and decreased HRV is an independent risk factor for sudden cardiac death. We aimed to determine the effect of sudden changes in serum electrolyte, bicarbonate concentration and blood pressure on HRV during hemodialysis (HD) sessions in chronic HD patients. METHODS: The study population included 75 HD patients (mean age 44.5 ± 10.3 years; 53% female, 13% diabetic) and 35 healthy volunteers (mean age 42.44 ± 11.5 years, 62% female). HRV indexes were analyzed from 24-hour ECG recordings. The time-domain HRV indexes (SDNN, SDANN, RMSSD, pNN50 [%] and HRV TAI) were calculated from these recordings. Pre- and post-HD blood samples were drawn from an arterial line to calculate Na+, K+, Ca2+, iCa2+ and HCO3- concentration gradients. RESULTS: All HRV indexes were significantly lower in dialysis patients than in healthy volunteers (p<0.05).The detected SDNN and HRV TAI values were lower in diabetic patients than in nondiabetics. While K+ concentration was decreased, Ca2+ and bicarbonate increased significantly during HD. CONCLUSION: HRV decreased in chronic HD patients. The decrease in HRV in diabetic uremic patients was higher than in uremic patients without diabetes. The change of serum electrolyte and bicarbonate concentrations during HD did not affect HRV.