Effect of shrinkage in photopolymer film on the information transmitted through the holographic waveguide for near eye displays.

Due to shrinkage in photopolymer materials, the angle of the reconstruction beam in holographic optical elements (HOEs) does not match with the Bragg condition, resulting in a decreased amount of light in the desired direction or loss of transmitted information to rematch the Bragg condition. Thus, to ensure final display features it is imperative to precompensate the shrinkage effect. We derived simplified expressions for precompensation in recording geometries of required HOEs in holographic waveguide-based Maxwellian near eye displays. An acceptable range of detuning from the Bragg angle is also analyzed. The experimentally measured 4.95% shrinkage in photopolymer film for 0° and 45° recording angles of beams was precompensated using -0.86∘ and 43.7° recording angles. Theoretical results are validated through simulation and experiments.

Bragg degenerate model for fabrication of holographic waveguide-based near-eye displays.

The coupling efficiency of light beams is a crucial factor for waveguide displays. Generally, the light beam is not coupled with maximum efficiency in the holographic waveguide without employing a prism in the recording geometry. Use of prisms in recording geometry leads to restricting the propagation angle of the waveguide to a specific value only. The issue of efficient coupling of a light beam without using prisms could be overcome via Bragg degenerate configuration. In this work, the simplified expressions of the Bragg degenerate case are obtained for the realization of normally illuminated waveguide-based displays. Using this model, by tuning the parameters of recording geometry, a range of propagation angles can be produced for a fixed normal incidence of a playback beam. Numerical simulations and experimental investigations of the Bragg degenerate waveguides of different geometries are performed to validate the model. A Bragg degenerate playback beam is successfully coupled in four waveguides recorded with different geometries and yields good diffraction efficiency at normal incidence. The quality of transmitted images is characterized using the structural similarity index measure. The augmentation of a transmitted image in the real world is experimentally demonstrated through the fabricated holographic waveguide for near-eye display applications. Bragg degenerate configuration can provide flexibility in the angle of propagation while maintaining the same coupling efficiency achievable with a prism for holographic waveguide displays.

Molecular mechanism of selective substrate engagement and inhibitor disengagement of cysteine synthase.

O-acetyl serine sulfhydrylase (OASS), referred to as cysteine synthase (CS), synthesizes cysteine from O-acetyl serine (OAS) and sulfur in bacteria and plants. The inherent challenge for CS is to overcome 4 to 6 log-folds stronger affinity for its natural inhibitor, serine acetyltransferase (SAT), as compared with its affinity for substrate, OAS. Our recent study showed that CS employs a novel competitive-allosteric mechanism to selectively recruit its substrate in the presence of natural inhibitor. In this study, we trace the molecular features that control selective substrate recruitment. To generalize our findings, we used CS from three different bacteria (Haemophilus, Salmonella, and Mycobacterium) as our model systems and analyzed structural and substrate-binding features of wild-type CS and its ∼13 mutants. Results show that CS uses a noncatalytic residue, M120, located 20 Šaway from the reaction center, to discriminate in favor of substrate. M120A and background mutants display significantly reduced substrate binding, catalytic efficiency, and inhibitor binding. Results shows that M120 favors the substrate binding by selectively enhancing the affinity for the substrate and disengaging the inhibitor by 20 to 286 and 5- to 3-folds, respectively. Together, M120 confers a net discriminative force in favor of substrate by 100- to 858-folds.

Therapeutics of premature hair graying: A long journey ahead.

Premature graying of hair has major psychosocial and socioeconomic repercussion, as it is considered as a sign of hastily progressing old age, ill health and often leads to loss of self-esteem. Hair is said to gray prematurely when it happens before the age of 20 years in Caucasians, 25 years in Asians, and 30 years in Africans. The hair color chiefly depends on melanin pigment, and fabrication of this pigment takes place in melanosomes through the process of melanogenesis. This complex biochemical pathway (melanogenesis) is further dependent on tyrosinase which acts as fuel.The normal human scalp is subjected to various factors categorized as intrinsic and extrinsic leading to graying of hair. Intrinsic factors comprise of variants responsible for changes at genetic level while extrinsic factors include air pollution, ultraviolet radiation, smoking, and nutrition. It has been proposed that direct or indirect effect of all these factors results in the generation of reactive oxygen species (ROS), thus leading to further damage. Though research has expanded in last few years in terms of microscopic, biochemical (hormonal, enzymatic), and molecular changes happening within hair follicle/shaft, still the exact mechanism leading to premature graying of hair is not well understood. Probable solutions toward this quandary are diet, herbal remedies, and temporary hair colorants. Ironically, the latter one being the most common has various side effects such as allergic reactions, inflammation, and hair loss. The aim of this paper was to review the manifestation and probable future interventions in preventing premature hair graying.

Blood transfusion safety: A study of adverse reactions at the blood bank of a tertiary care center.

BACKGROUND: An adverse transfusion reaction (ATR) is an unfavorable reaction to the transfused unit, the severity of which may be different among individuals depending upon the type of reaction and the patient's susceptibility. Transfusion reactions may be immediate or delayed type depending on the onset and immune or nonimmune type depending on the pathogenesis. A study was conducted to study the frequency of various transfusion reactions and the associated morbidity. MATERIALS AND METHODS: All ATRs occurring over a period of 3 years at a tertiary care health center were studied in detail according to the institute's protocol. RESULTS: Of 38,013 units of blood and components that had been issued, 101 (0.2%) cases had an ATR. The most common reaction was allergic - 34/101 (33.6%) followed by febrile - 26/101 (25.7%). Other reactions included transfusion-related acute lung injury in 6/101 (5.9%) cases, and immune reactions were seen in 19/101 (18.8%) cases. CONCLUSION: Allergic and febrile reactions are most common and least harmful, but fatal reactions can also occur, and preventive measures must be taken to avoid such reactions.