Búsqueda | BVS CLAP/SMR-OPS/OMS

1.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock, Benjamin A; Moslehi, Javid; Baik, Alan H; Davidson, Shawn M; Williams, Jeremy; Gibson, William J; Chakraborty, Abhishek A; Pierce, Kerry A; Miller, Christine M; Hanse, Eric A; Kelekar, Ameeta; Sullivan, Lucas B; Wagers, Amy J; Clish, Clary B; Vander Heiden, Matthew G; Kaelin, William G.

Cell ; 164(5): 884-95, 2016 Feb 25.

Artículo en Inglés | MEDLINE | ID: mdl-26919427

2.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock, Benjamin A; Moslehi, Javid; Baik, Alan H; Davidson, Shawn M; Williams, Jeremy; Gibson, William J; Chakraborty, Abhishek A; Pierce, Kerry A; Miller, Christine M; Hanse, Eric A; Kelekar, Ameeta; Sullivan, Lucas B; Wagers, Amy J; Clish, Clary B; Vander Heiden, Matthew G; Kaelin, William G.

Cell ; 165(2): 497, 2016 Apr 07.

Artículo en Inglés | MEDLINE | ID: mdl-27058668

3.

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8⁺ T cells.

Borges da Silva, Henrique; Beura, Lalit K; Wang, Haiguang; Hanse, Eric A; Gore, Reshma; Scott, Milcah C; Walsh, Daniel A; Block, Katharine E; Fonseca, Raissa; Yan, Yan; Hippen, Keli L; Blazar, Bruce R; Masopust, David; Kelekar, Ameeta; Vulchanova, Lucy; Hogquist, Kristin A; Jameson, Stephen C.

Nature ; 559(7713): 264-268, 2018 07.

Artículo en Inglés | MEDLINE | ID: mdl-29973721

4.

Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis.

Jemmerson, Ronald; Staskus, Katherine; Higgins, LeeAnn; Conklin, Kathleen; Kelekar, Ameeta.

Apoptosis ; 26(1-2): 71-82, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33386492

5.

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose.

Lowman, Xazmin H; McDonnell, Maureen A; Kosloske, Ashley; Odumade, Oludare A; Jenness, Christopher; Karim, Christine B; Jemmerson, Ronald; Kelekar, Ameeta.

Mol Cell ; 40(5): 823-33, 2010 Dec 10.

Artículo en Inglés | MEDLINE | ID: mdl-21145489

6.

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.

Wanhainen, Kelsey M; Peng, Changwei; Zhou, Maggie H; Macedo, Bruna de Gois; O'Flanagan, Stephen; Yang, Tingyuan; Kelekar, Ameeta; Burbach, Brandon J; Borges da Silva, Henrique; Jameson, Stephen C.

Cancer Immunol Res ; 10(7): 871-884, 2022 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-35588154

7.

Activation of autophagy in mesenchymal stem cells provides tumor stromal support.

Sanchez, Cecilia G; Penfornis, Patrice; Oskowitz, Adam Z; Boonjindasup, Aaron G; Cai, David Z; Dhule, Santosh S; Rowan, Brian G; Kelekar, Ameeta; Krause, Diane S; Pochampally, Radhika R.

Carcinogenesis ; 32(7): 964-72, 2011 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-21317300

8.

CoAching CD8⁺ T cells for tumor immunotherapy-the pantothenate way.

Kelekar, Ameeta; Jameson, Stephen C.

Cell Metab ; 33(12): 2305-2306, 2021 12 07.

Artículo en Inglés | MEDLINE | ID: mdl-34879235

9.

Phosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK.

Yan, Yan; Krecke, Karl N; Bapat, Aditi S; Yang, Tingyuan; Lopresti, Michael W; Mashek, Douglas G; Kelekar, Ameeta.

Cell Death Dis ; 12(10): 904, 2021 10 04.

Artículo en Inglés | MEDLINE | ID: mdl-34608126

10.

Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis.

Matias, Maria I; Yong, Carmen S; Foroushani, Amir; Goldsmith, Chloe; Mongellaz, Cédric; Sezgin, Erdinc; Levental, Kandice R; Talebi, Ali; Perrault, Julie; Rivière, Anais; Dehairs, Jonas; Delos, Océane; Bertand-Michel, Justine; Portais, Jean-Charles; Wong, Madeline; Marie, Julien C; Kelekar, Ameeta; Kinet, Sandrina; Zimmermann, Valérie S; Levental, Ilya; Yvan-Charvet, Laurent; Swinnen, Johannes V; Muljo, Stefan A; Hernandez-Vargas, Hector; Tardito, Saverio; Taylor, Naomi; Dardalhon, Valérie.

Cell Rep ; 37(5): 109911, 2021 11 02.

Artículo en Inglés | MEDLINE | ID: mdl-34731632

11.

Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1.

Codina, Ramil; Vanasse, Amelia; Kelekar, Ameeta; Vezys, Vaiva; Jemmerson, Ronald.

Apoptosis ; 15(2): 139-52, 2010 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-19851871

12.

Increased ceramide accumulation correlates with downregulation of the autophagy protein ATG-7 in MCF-7 cells sensitized to photodamage.

Separovic, Duska; Kelekar, Ameeta; Nayak, Arun K; Tarca, Adi L; Hanada, Kentaro; Pierce, Jason S; Bielawski, Jacek.

Arch Biochem Biophys ; 494(1): 101-5, 2010 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-19944062

13.

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

Zhao, Yuxing; Altman, Brian J; Coloff, Jonathan L; Herman, Catherine E; Jacobs, Sarah R; Wieman, Heather L; Wofford, Jessica A; Dimascio, Leah N; Ilkayeva, Olga; Kelekar, Ameeta; Reya, Tannishtha; Rathmell, Jeffrey C.

Mol Cell Biol ; 27(12): 4328-39, 2007 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-17371841

14.

Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels.

Nguyen, Tri Minh Bui; Subramanian, Indira V; Xiao, Xue; Ghosh, Goutam; Nguyen, Phan; Kelekar, Ameeta; Ramakrishnan, S.

J Cell Mol Med ; 13(9B): 3687-98, 2009 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-19298526

15.

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.

McDonald-Hyman, Cameron; Muller, James T; Loschi, Michael; Thangavelu, Govindarajan; Saha, Asim; Kumari, Sudha; Reichenbach, Dawn K; Smith, Michelle J; Zhang, Guoan; Koehn, Brent H; Lin, Jiqiang; Mitchell, Jason S; Fife, Brian T; Panoskaltsis-Mortari, Angela; Feser, Colby J; Kirchmeier, Andrew Kemal; Osborn, Mark J; Hippen, Keli L; Kelekar, Ameeta; Serody, Jonathan S; Turka, Laurence A; Munn, David H; Chi, Hongbo; Neubert, Thomas A; Dustin, Michael L; Blazar, Bruce R.

J Clin Invest ; 128(10): 4604-4621, 2018 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-30106752

16.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo, Zhijun; Sevrioukova, Irina F; Denisov, Ilia G; Zhang, Xia; Chiu, Ting-Lan; Thomas, Dafydd G; Hanse, Eric A; Cuellar, Rebecca A D; Grinkova, Yelena V; Langenfeld, Vanessa Wankhede; Swedien, Daniel S; Stamschror, Justin D; Alvarez, Juan; Luna, Fernando; Galván, Adela; Bae, Young Kyung; Wulfkuhle, Julia D; Gallagher, Rosa I; Petricoin, Emanuel F; Norris, Beverly; Flory, Craig M; Schumacher, Robert J; O'Sullivan, M Gerard; Cao, Qing; Chu, Haitao; Lipscomb, John D; Atkins, William M; Gupta, Kalpna; Kelekar, Ameeta; Blair, Ian A; Capdevila, Jorge H; Falck, John R; Sligar, Stephen G; Poulos, Thomas L; Georg, Gunda I; Ambrose, Elizabeth; Potter, David A.

Cell Chem Biol ; 24(10): 1259-1275.e6, 2017 Oct 19.

Artículo en Inglés | MEDLINE | ID: mdl-28919040

17.

Autophagy.

Kelekar, Ameeta.

Ann N Y Acad Sci ; 1066: 259-71, 2005 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-16533930

18.

High-resolution structural characterization of Noxa, an intrinsically disordered protein, by microsecond molecular dynamics simulations.

Espinoza-Fonseca, L Michel; Kelekar, Ameeta.

Mol Biosyst ; 11(7): 1850-6, 2015 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-25855872

19.

Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation.

Karim, Christine B; Espinoza-Fonseca, L Michel; James, Zachary M; Hanse, Eric A; Gaynes, Jeffrey S; Thomas, David D; Kelekar, Ameeta.

Sci Rep ; 5: 14557, 2015 Sep 28.

Artículo en Inglés | MEDLINE | ID: mdl-26411306

20.

Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein gene.

Vallera, Daniel A; Jin, Ni; Shu, Yanqun; Panoskaltsis-Mortari, Angela; Kelekar, Ameeta; Chen, Wei.

Hum Gene Ther ; 14(18): 1787-98, 2003 Dec 10.

Artículo en Inglés | MEDLINE | ID: mdl-14670129

BVS CLAP/SMR-OPS/OMS

Centro Latinoamericano de Perinatología, Salud de la Mujer y Reproductiva

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EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8⁺ T cells.

Intracellular leucine-rich alpha-2-glycoprotein-1 competes with Apaf-1 for binding cytochrome c in protecting MCF-7 breast cancer cells from apoptosis.

The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose.

P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell Therapy.

Activation of autophagy in mesenchymal stem cells provides tumor stromal support.

CoAching CD8⁺ T cells for tumor immunotherapy-the pantothenate way.

Phosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK.

Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis.

Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1.

Increased ceramide accumulation correlates with downregulation of the autophagy protein ATG-7 in MCF-7 cells sensitized to photodamage.

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels.

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Autophagy.

High-resolution structural characterization of Noxa, an intrinsically disordered protein, by microsecond molecular dynamics simulations.

Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation.

Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an interleukin-3/Bax fusion protein gene.