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1.
Cerebellum ; 18(6): 1126-1129, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31161534

RESUMEN

Paraneoplastic cerebellar degeneration (PCD) is a rare disorder that is associated with lung or gynecological malignancies and Hodgkin lymphoma. Neurologic symptoms are commonly the initial presenting sign leading to the diagnosis of an underlying malignancy. We are presenting an Asian male with progressive lower extremity weakness with EBV-positive nasopharyngeal carcinoma (NPC) and anti-Yo antibodies. Peculiarly, transient diffuse leptomeningeal enhancement is seen on MR imaging. This is the first report of PCD associated with NPC and thus illustrates that PCD embodies a boarder set of disease than previously described.


Asunto(s)
Carcinoma Nasofaríngeo/diagnóstico por imagen , Neoplasias Nasofaríngeas/diagnóstico por imagen , Degeneración Cerebelosa Paraneoplásica/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana Edad , Carcinoma Nasofaríngeo/complicaciones , Carcinoma Nasofaríngeo/terapia , Neoplasias Nasofaríngeas/complicaciones , Neoplasias Nasofaríngeas/terapia , Degeneración Cerebelosa Paraneoplásica/complicaciones , Degeneración Cerebelosa Paraneoplásica/terapia
2.
Catheter Cardiovasc Interv ; 54(3): 339-41, 2001 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-11747160

RESUMEN

Intra-arterial (IA) recombinant tissue plasminogen activator (rt-PA) is an investigational treatment for acute stroke. We report a case of IA thrombolysis of a hyperacute middle cerebral artery stroke 5 days after coronary artery bypass graft surgery. Despite a serious extracranial bleeding complication (hemothorax), immediate thrombolysis with IA rt-PA led to near complete resolution of the neurological deficit and a favorable outcome.


Asunto(s)
Infarto de la Arteria Cerebral Media/tratamiento farmacológico , Infarto de la Arteria Cerebral Media/etiología , Complicaciones Posoperatorias/tratamiento farmacológico , Complicaciones Posoperatorias/etiología , Anciano , Puente de Arteria Coronaria , Humanos , Infusiones Intraarteriales , Masculino , Terapia Trombolítica , Activador de Tejido Plasminógeno/uso terapéutico , Tomografía Computarizada por Rayos X
3.
J Neurol Neurosurg Psychiatry ; 75(9): 1265-9, 2004 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-15314112

RESUMEN

BACKGROUND AND OBJECTIVES: Hyperekplexia and the stiff-man syndrome (SMS) are both conditions with exaggerated startle suggesting abnormal brainstem function. Investigation of brainstem reflexes may provide insight into disturbed reflex excitation and inhibition underlying these movement disorders. PATIENTS AND METHODS: Using four-channel EMG, we examined four trigeminal brainstem reflexes (monosynaptic masseter, masseter inhibitory, glabella, and orbicularis oculi blink reflexes) and their spread into pericranial muscles in five patients with familial hyperekplexia (FH), two with acquired hyperekplexia (AH), 10 with SMS, and 15 healthy control subjects. RESULTS: Both FH/AH and SMS patients had abnormal propagation of brainstem reflexes into pericranial muscles. All patients with hyperekplexia showed an abnormal short-latency (15-20 ms) reflex in the trapezius muscle with a characteristic clinical appearance ("head retraction jerk") evoked by tactile or electrical stimulation of the trigeminal nerve, but normal monosynaptic masseter reflexes. Inhibitory brainstem reflexes were attenuated in some FH/AH patients. Four of 10 patients with SMS had similar short-latency reflexes in the neck muscles and frequently showed widespread enhancement of other excitatory reflexes, reflex spasms, and attenuation of inhibitory brainstem reflexes. CONCLUSION: Reflex excitation is exaggerated and inhibition is attenuated in both stiff-man syndrome and familial or acquired hyperekplexia, indicating a physiological relationship. Reflex transmission in the brainstem appears biased towards excitation which may imply dysfunction of inhibitory glycinergic or GABAergic interneurons, or both.


Asunto(s)
Tronco Encefálico/fisiología , Reflejo Anormal , Reflejo de Sobresalto/fisiología , Síndrome de la Persona Rígida/fisiopatología , Adolescente , Adulto , Anciano , Estudios de Casos y Controles , Niño , Preescolar , Electromiografía , Femenino , Humanos , Lactante , Masculino , Persona de Mediana Edad , Tiempo de Reacción , Nervio Trigémino/fisiología
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