The Association of Metabolic-Associated Fatty Liver Disease with Clinical Outcomes of COVID-19: A Systematic Review and Meta-Analysis.

Introduction: Metabolic-associated fatty liver disease (MAFLD) is a hepatic manifestation of metabolic syndrome (MS). MAFLD patients have a higher prevalence of COVID-19. MAFLD also is associated with worse clinical outcomes of COVID-19, such as disease severity, intensive care unit (ICU) admission rate, and higher mortality rates. However, this evidence has not been well characterized in the literature. This meta-analysis aimed to determine the clinical outcomes of COVID-19 among MAFLD patients compared to the non-MAFLD group. Methods: A comprehensive search was conducted in the Cumulative Index of Nursing and Allied Health (CINAHL), PubMed/Medline, and Embase for studies reporting MAFLD prevalence among COVID-19 patients and comparing clinical outcomes such as severity, ICU admission, and mortality among patients with and without MAFLD. The pooled prevalence of MAFLD among COVID-19 patients and the pooled odds ratios (OR) with 95% confidence intervals (CI) for clinical outcomes of COVID-19 were calculated. Results: Sixteen observational studies met inclusion criteria involving a total of 11,484 overall study participants, including 1,746 MAFLD patients. The prevalence of COVID-19 among MAFLD patients was 0.29 (95% CI: 0.19-0.40). MAFLD was associated with the COVID-19 disease severity OR 3.07 (95% CI: 2.30-4.09). Similarly, MAFLD was associated with an increased risk of ICU admission compared to the non-MAFLD group OR 1.46 (95% CI: 1.12-1.91). Lastly, the association between MAFLD and COVID-19 mortality was not statistically significant OR 1.45 (95% CI: 0.74-2.84). Conclusions: In this study, a high percentage of COVID-19 patients had MAFLD. Moreover, MAFLD patients had an increased risk of COVID-19 disease severity and ICU admission rate.

Functional outcome after percutaneous tendo-Achilles lengthening.

BACKGROUND: Percutaneous tendo-Achilles lengthening (PTAL) is a common procedure performed as an adjunct to other procedures that are used to treat a variety of foot and ankle disorders. Despite the widespread use of PTAL, the only literature to substantiate its efficacy comes from the treatment of forefoot ulceration in diabetics. The complications of the procedure include pain along the Achilles tendon, difficulty using stairs, weakness with toe-off, inadvertent complete tenotomy, and cosmetic appearance. We sought to investigate the functional outcomes specific to PTAL when performed in tandem with triple arthrodesis and subtalar fusion. MATERIALS AND METHODS: A retrospective review of 107 patients who underwent 117 procedures was performed. Outcomes were assessed by telephone interview using a standard questionnaire. The most common procedure in the study population was triple arthrodesis (91%). RESULTS: Fifty-eight percent of the patients reported moderate improvement in motion postoperatively, but 80% reported some degree of persistent stiffness. Despite 38% of patients reporting postoperative weakness, 66% and 61% stated that ascending and descending stairs, respectively, was easier. CONCLUSION: Overall, 81% of the study population had a positive opinion regarding their surgery. In this heterogeneous population, we showed modest improvement in Achilles tendon-related outcomes when PTAL was performed in tandem with other surgeries.

WATS3D versus forceps biopsy in screening for Barrett's esophagus: experience in community endoscopy centers.

BACKGROUND: Barrett's esophagus (BE) is a premalignant condition diagnosed using systematic 4-quadrant forceps biopsies (FB) during endoscopy. This method is fraught with errors due to the randomness of sampling and variability among operators. Wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS3D) is an emerging technique used to collect esophageal samples. The aim of this study was to evaluate WATS3D as a diagnostic tool for detecting BE in addition to FB, compared to FB alone. METHODS: A retrospective observational cohort study was conducted and included patients who underwent screening for BE with WATS3D and FB between January 2015 and January 2019 across 3 endoscopy centers in Wichita, Kansas. The FB specimens were reviewed by community pathologists, while the WATS3D samples were sent to CDX technology labs, NY. RESULTS: A total of 108 patients were screened for BE using both modalities concurrently. FB and WATS3D detected 62 (57.4%) and 83 (76%) cases of BE, respectively. The absolute difference of 21 cases (18.6%) of BE was attributed to the addition of WATS3D. The number needed to test with WATS3D was 5. We divided the sample into 4 groups to compare the agreement across all groups: (FB-; WATS3D+), (FB-; WATS3D-), (FB+; WATS3D+), and (FB+ and WATS3D-). Overall agreement by kappa statistic was 0.74. CONCLUSION: WATS3D identified 21 cases of BE missed by FB. Using WATS3D in addition to FB increased the yield of BE during surveillance endoscopy, with no increase in complications.

Neuroimaging as a guide to predict outcomes for patients with coccidioidal meningitis.

Sixty-two patients with coccidioidal meningitis underwent neuroimaging. Magnetic resonance imaging detected neuroimaging abnormalities in 76% of patients, and computed tomography scanning detected neuroimaging abnormalities in 41.6%. The most common abnormal neuroimaging findings were hydrocephalus (51.6%), basilar meningitis (46.8%), and cerebral infarction (38.7%). Significantly elevated mortality rates were associated with hydrocephalus and hydrocephalus coexisting with infarction. Basilar meningitis did not influence outcome. Patients without neuroimaging abnormalities had a mortality rate of 7.7%.

Calcaneal tumors and tumor-like conditions.

Approximately 3% of osseous tumors occur in the foot and ankle. Solitary bone cysts, chondroblastoma, intraosseous lipoma, osteoid osteoma, chondrosarcoma, and Ewing's sarcoma seem to have a predilection for the calcaneus. Biopsy is often a crucial step in management. Tumor-like conditions, such as cysts, reactive lesions, and osteomyelitis, must be considered during evaluation. Treatment is often observation or curettage of benign lesions and resection or amputation for malignancies.

Hypercalcemia in patients with disseminated coccidioidomycosis.

OBJECTIVE: Granulomatous disorders may be associated with hypercalcemia. In sarcoidosis, the pathogenesis of hypercalcemia has been clarified, whereas in other granulomatous disorders, such as coccidioidomycosis, the mechanism is unclear. We present 13 patients with coccidioidomycosis and hypercalcemia to illustrate the clinical course and the mechanism of hypercalcemia. METHODS: We retrospectively reviewed all patients admitted to Kern Medical Center, a 270-bed public hospital, from 1990 through 1997 with coccidioidomycosis and a serum calcium level of greater than 10.5 mg/dL on at least 3 occasions. In addition, no other causes for hypercalcemia were identified. RESULTS: The mean highest serum calcium level was 12.7 +/- 1.8 mg/dL. All patients had disseminated disease. Six patients were nonambulatory and 4 had bone involvement. Of the 9 patients in whom parathyroid hormone was measured, it was normal in 6 and suppressed in 3. Of the 9 patients in whom 25-hydroxyvitamin D was measured, it was normal in 6, suppressed in 2, and elevated in 1. Of the 7 patients in whom 1,25-dihydroxyvitamin D was measured, it was normal in 3 and suppressed in 4. Urinary calcium was elevated in 2 patients, both of whom were ambulatory. Nonambulatory patients had significantly higher serum calcium levels (14.3 +/- 1.0 mg/dL) than ambulatory patients (11.3 +/- 0.46 mg/dL) (P<0.001). CONCLUSIONS: The mechanism of hypercalcemia in coccidioidomycosis is unrelated to increased production of 1,25-dihydroxyvitamin D. Nonambulatory status is associated with higher mean serum calcium.

Bacterial shedding in common spine surgical procedures: headlamp/loupes and the operative microscope.

STUDY DESIGN: Simulated discectomy was performed using 1) headlamp/loupes, 2) the operative microscope, or 3) neither; and bacterial shedding was assessed using air sampler/settle plate techniques. OBJECTIVES: To determine the potential contribution of these 2 commonly used systems of magnification/illumination to postoperative infection by using a controlled, experimental setting to limit confounding factors. SUMMARY OF BACKGROUND DATA: Postoperative infections following surgery on the degenerative lumbar spine generally range from 0.6% to 6%. Headlamp/loupes and the operative microscope may contribute to potential infection, but, to date, the contribution to shedding rates while using these tools has not been assessed. METHODS: Seventy samples from simulated discectomies within the usual sterile operative setting were collected using a 2-stage air sampler/settle plate technique. Group 1 (30 samples) used the operative microscope, Group 2 (30 samples) used headlamp/loupes, and Group 3 (10 samples) used neither as a control. Collected samples were examined for bacterial growth using blood agar plates and were assessed qualitatively and quantitatively. RESULTS: Greater than half of the collected samples in Groups 1 and 2 demonstrated bacterial growth with coagulase negative Staphylococcus being found in nearly all positive samples and secondary species being common. No statistical differences between the 2 groups were noted for number of samples with growth, species of bacterial growth, number with growth of secondary species, or colony counts. Both groups demonstrated significantly greater number of samples with growth relative to the control Group 3. CONCLUSIONS: The use of headlamp/loupes or the operative microscope is associated with bacterial shedding. Proper techniques of cleaning, storage, and draping should be used to minimize their contribution to potential postoperative infection. No significant difference was noted between the 2 test groups, suggesting that infection risk should not come into play when choosing techniques of illumination/magnification.

Next-to-next-to-leading order Higgs production at Hadron Colliders.

The Higgs-boson production cross section at pp and pp colliders is calculated in QCD at next-to-next-to-leading order (NNLO). We find that the perturbative expansion of the production cross section is well behaved and that scale dependence is reduced relative to the NLO result. These findings give us confidence in the reliability of the prediction. We also report an error in the NNLO correction to Drell-Yan production.