Vein visualization using a smart phone with multispectral Wiener estimation for point-of-care applications.

Effective vein visualization is clinically important for various point-of-care applications, such as needle insertion. It can be achieved by utilizing ultrasound imaging or by applying infrared laser excitation and monitoring its absorption. However, while these approaches can be used for vein visualization, they are not suitable for point-of-care applications because of their cost, time, and accessibility. In this paper, a new vein visualization method based on multispectral Wiener estimation is proposed and its real-time implementation on a smart phone is presented. In the proposed method, a conventional RGB camera on a commercial smart phone (i.e., Galaxy Note 2, Samsung Electronics Inc., Suwon, Korea) is used to acquire reflectance information from veins. Wiener estimation is then applied to extract the multispectral information from the veins. To evaluate the performance of the proposed method, an experiment was conducted using a color calibration chart (ColorChecker Classic, X-rite, Grand Rapids, MI, USA) and an average root-mean-square error of 12.0% was obtained. In addition, an in vivo subcutaneous vein imaging experiment was performed to explore the clinical performance of the smart phone-based Wiener estimation. From the in vivo experiment, the veins at various sites were successfully localized using the reconstructed multispectral images and these results were confirmed by ultrasound B-mode and color Doppler images. These results indicate that the presented multispectral Wiener estimation method can be used for visualizing veins using a commercial smart phone for point-of-care applications (e.g., vein puncture guidance).

Evaluation of ultrasound synthetic aperture imaging using bidirectional pixel-based focusing: preliminary phantom and in vivo breast study.

In medical ultrasound imaging, lateral resolution is limited when using a fixed transmit focusing. Various synthetic aperture (SA) techniques, in which two-way dynamic focusing is enabled by utilizing prebeamformed radio-frequency (RF) data have been proposed for improving the spatial resolution. However, SA methods were not extensively evaluated in terms of their clinical performance. In this paper, a phantom and an in vivo evaluation of the SA method with bidirectional pixel-based focusing (BiPBF) is presented in comparison with the conventional beamforming. The performance of the proposed SA-BiPBF was assessed with a blind study and the established breast imaging-reporting and data system (BI-RADS), in addition to measuring contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR). Prebeamformed RF data were acquired from a tissue mimicking phantom (Model 040, CIRS Inc., Norfolk, VA, USA) and from patients with breast lesions by using a commercial ultrasound scanning system with a linear array transducer equipped with a research package and parallel data acquisition system (SonixTouch, SonixDAQ, and L14-5/38, Ultrasonix Corp., Canada). In phantom and in vivo experiments, a default setting of a breast preset was applied (e.g., the center frequency of 10 MHz and acoustic output of MI = 0.66). In phantom experiment, the SA-BiPBF method showed higher CNR and SNR values compared to the conventional method (3.4 and 23.9 dB versus 3.1 and 15.8 dB, respectively). In addition, the lateral resolution and penetration depth were increased by 95.4% and 40.3%, respectively. Consistent with the phantom experiment, in the in vivo experiment with ten patients, the CNR value for the SA method was 3.3 ± 0.5 compared to 2.8 ± 0.8 for the conventional method. Similarly, the SNR values with the SA-BiPBF and conventional methods were 34.0 ± 3.6 and 27.2 ± 3.4 dB, respectively. From the experiments, it was shown in side-by-side comparisons that the image quality of the SA-BiPBF method was considerably improved in both phantom and in vivo breast images. However, the SA-BiPBF image showed different features compared to the conventional one in the in vivo experiments. These features are resulting from the increased image quality of the SA-BiPBF method but are not always perceived as improvements by the radiologists.

Synthetic aperture imaging in breast ultrasound: a preliminary clinical study.

RATIONALE AND OBJECTIVES: To compare the image quality between conventional and synthetic aperture (SA) imaging in breast ultrasound (US). MATERIALS AND METHODS: Twenty-four patients with 31 breast lesions were included in our study. The US data were processed with SA algorithm. For quantitative analysis, contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) were calculated. For qualitative analysis, conventional and SA images were reviewed by three radiologists and diagnostic preference (conspicuity, margin sharpness, and contrast) was assessed. The radiologists also determined whether artifacts were present. Parameters were analyzed using a paired t-test, Wilcoxon signed-rank test, and chi-square test. RESULTS: The mean CNRs were higher in SA images compared with conventional images (mean, 2.56 versus 2.28, P = .004). The mean SNRs were higher in SA images compared with conventional images (31.62 versus 25.26, P < .0001). SA images were considered as being "better" or "much better" in 16-23 (51.6-74.2%) lesions of total 31 lesions for conspicuity, in 17-24 (45.2%-77.4%) for margin sharpness, and in 13-23 (41.9%-74.2%) for contrast. Significant preferences in SA images were demonstrated (conspicuity, P < .05 for all radiologists; margin sharpness and contrast in two radiologists). Refraction and speckle artifacts were less frequently observed in SA images (refraction, P < .05 for all radiologists; speckle, P < .05 for two radiologists), whereas reflection artifacts were more frequent in SA images (P < .05 in two radiologists). CONCLUSION: SA imaging provides better image quality than conventional imaging in patients with focal breast lesions in breast US.