RESUMEN
BACKGROUND: Airway obstruction is defined by spirometry as a low forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio. This impaired ratio may originate from a low FEV1 (classic) or a normal FEV1 in combination with a large FVC (dysanaptic). The clinical implications of dysanaptic obstruction during childhood and adolescence in the general population remain unclear. AIMS: To investigate the association between airway obstruction with a low or normal FEV1 in childhood and adolescence, and asthma, wheezing and bronchial hyperresponsiveness (BHR). METHODS: In the BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology; Sweden) and PIAMA (Prevention and Incidence of Asthma and Mite Allergy; the Netherlands) birth cohorts, obstruction (FEV1:FVC ratio less than the lower limit of normal, LLN) at ages 8, 12 (PIAMA only) or 16 years was classified as classic (FEV1 Asunto(s)
Obstrucción de las Vías Aéreas
, Asma
, Ruidos Respiratorios
, Espirometría
, Humanos
, Niño
, Volumen Espiratorio Forzado/fisiología
, Adolescente
, Masculino
, Femenino
, Asma/fisiopatología
, Asma/epidemiología
, Ruidos Respiratorios/fisiopatología
, Obstrucción de las Vías Aéreas/fisiopatología
, Capacidad Vital/fisiología
, Suecia/epidemiología
, Prevalencia
, Estudios Transversales
, Hiperreactividad Bronquial/fisiopatología
, Hiperreactividad Bronquial/epidemiología
, Países Bajos/epidemiología