RESUMEN
Many procedures in modern clinical medicine rely on the use of electronic implants in treating conditions that range from acute coronary events to traumatic injury. However, standard permanent electronic hardware acts as a nidus for infection: bacteria form biofilms along percutaneous wires, or seed haematogenously, with the potential to migrate within the body and to provoke immune-mediated pathological tissue reactions. The associated surgical retrieval procedures, meanwhile, subject patients to the distress associated with re-operation and expose them to additional complications. Here, we report materials, device architectures, integration strategies, and in vivo demonstrations in rats of implantable, multifunctional silicon sensors for the brain, for which all of the constituent materials naturally resorb via hydrolysis and/or metabolic action, eliminating the need for extraction. Continuous monitoring of intracranial pressure and temperature illustrates functionality essential to the treatment of traumatic brain injury; the measurement performance of our resorbable devices compares favourably with that of non-resorbable clinical standards. In our experiments, insulated percutaneous wires connect to an externally mounted, miniaturized wireless potentiostat for data transmission. In a separate set-up, we connect a sensor to an implanted (but only partially resorbable) data-communication system, proving the principle that there is no need for any percutaneous wiring. The devices can be adapted to sense fluid flow, motion, pH or thermal characteristics, in formats that are compatible with the body's abdomen and extremities, as well as the deep brain, suggesting that the sensors might meet many needs in clinical medicine.
Asunto(s)
Implantes Absorbibles , Encéfalo/metabolismo , Electrónica/instrumentación , Monitoreo Fisiológico/instrumentación , Prótesis e Implantes , Silicio , Implantes Absorbibles/efectos adversos , Administración Cutánea , Animales , Temperatura Corporal , Encéfalo/cirugía , Diseño de Equipo , Hidrólisis , Masculino , Monitoreo Fisiológico/efectos adversos , Especificidad de Órganos , Presión , Prótesis e Implantes/efectos adversos , Ratas , Ratas Endogámicas Lew , Telemetría/instrumentación , Tecnología Inalámbrica/instrumentaciónRESUMEN
We design, fabricate, and characterize a multilayer nanophotonic structure that couples light from standard optical fiber to an integrated photonics chip with unprecedented efficiency. The structure comprises a multilayer waveguide array tapering into a single waveguide supporting only fundamental TE- and TM-like modes. Measurements reveal a record-setting fiber-to-chip coupling efficiency of ${98.3}\% \;{\pm}\;{0.3}\%$ per facet at a 1575 nm wavelength that remains greater than ${92.8}\% \;{\pm}\;{0.4}\%$ across the 1550-1600 nm wavelength range. This approach is tailorable to any material platform, fiber type, or operating wavelength and represents a significant step forward for the accessibility of integrated photonics.
RESUMEN
The emergence and growth of transformation optics over the past decade has revitalized interest in how a gradient refractive index (GRIN) can be used to control light propagation. Two-dimensional demonstrations with lithographically defined silicon (Si) have displayed the power of GRIN optics and also represent a promising opportunity for integrating compact optical elements within Si photonic integrated circuits. Here, we demonstrate the fabrication of three-dimensional Si-based GRIN micro-optics through the shape-defined formation of porous Si (PSi). Conventional microfabrication creates Si square microcolumns (SMCs) that can be electrochemically etched into PSi elements with nanoscale porosity along the shape-defined etching pathway, which imparts the geometry with structural birefringence. Free-space characterization of the transmitted intensity distribution through a homogeneously etched PSi SMC exhibits polarization splitting behavior resembling that of dielectric metasurfaces that require considerably more laborious fabrication. Coupled birefringence/GRIN effects are studied by way of PSi SMCs etched with a linear (increasing from edge to center) GRIN profile. The transmitted intensity distribution shows polarization-selective focusing behavior with one polarization focused to a diffraction-limited spot and the orthogonal polarization focused into two laterally displaced foci. Optical thickness-based analysis readily predicts the experimentally observed phenomena, which strongly match finite-element electromagnetic simulations.
RESUMEN
A deterministic graphene-sandwiched Li-ion battery electrode consisting of an integrated 3D mesostructure of electrochemically active materials and graphene is presented. As demonstrations, electrodes with active nanomaterials that coat (V2 O5 @graphene@V2 O5 cathode) or are coated by (graphene@Si@graphene anode) graphene are fabricated. These electrodes exhibit high capacities and ultralong cycle lives (the cathode can be cycled over 2000 times with minimal capacity fade).