[Prognostic value of epithelial growth factor receptor, vascular endothelial growth factor, E-cadherin, and p120 catenin in resected non-small cell lung carcinoma]. / Valor pronóstico del receptor del factor de crecimiento epitelial, factor de crecimiento endotelial vascular, E-cadherina, y p120 catenina en el carcinoma de pulmón no microcítico resecado.

INTRODUCTION: Several markers have been investigated to predict the prognosis of lung cancer. In the present study, the prognostic values of epithelial growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), E-cadherin, and p120 catenin expression were investigated by immunohistochemistry in patients with a surgically resected non-small cell lung carcinoma (NSCLC). PATIENTS AND METHOD: EGFR, VEGF, E-cadherin, and p120 catenin expression were prospectively determined in resected specimens from patients with NSCLC who had undergone surgery between 2003 and 2007. Patients' and disease-related general characteristics and survival rate were recorded. RESULTS: One hundred seventeen patients with a mean age of 61.3 years were included in the study. After a mean follow-up of 27.5 months, the median survival was determined to be 44.0 months and the 5-year survival was 46.2%. The 5-year survival in negative and positive staining groups were as follows; 32% and 66.7% for EGFR (p = 0.02), 37.8% and 50.7% for VEGF (p = 0.5), 41% and 66% for E-cadherin (p = 0.19), 46% and 50% for p120 catenin (p = 0.27). The differentiation, N status, stage and EGFR staining were variables significantly affecting survival (p = 0.001, 0.006, 0.03 and 0.02 respectively). In multivariate Cox analysis, the EGFR staining level and N status were variables those significantly affecting survival (p = 0.021 and p = 0.010). CONCLUSIONS: While negative staining of EGFR was related with poor survival, staining of VEGF, E-cadherin, and p120 catenin were not related with survival in patients with resected NSCLC.

Primary intrathoracic extrapulmonary hydatid cysts: analysis of 14 patients with a rare clinical entity.

Primary hydatid cysts very rarely form in intrathoracic yet extrapulmonary sites. Accurate preoperative diagnosis in such cases is difficult, and corrective surgical procedures necessarily differ from those that are used to treat the far more typical pulmonary or hepatic hydatid cysts. We retrospectively evaluated the diagnostic and operative characteristics of intrathoracic extrapulmonary hydatid cysts, and we examined the outcome of aggressive surgical interventions that went beyond conventional parenchymal-sparing procedures.From 2003 through 2007, 14 patients (mean age, 39.14 +/- 16.8 yr) underwent surgical treatment in our hospital for primary intrathoracic extrapulmonary hydatid cysts. These cysts were variously in the diaphragm, chest wall, mediastinum, pleura, and pericardial cavity. All patients underwent cystectomy, decortication, resection, and repair of the adjacent structure. No complication, recurrence, or death occurred in the follow-up period of 15 +/- 18.1 months (range, 2-52 mo).In order to achieve complete resection and to avoid recurrence of disease from intrathoracic extrapulmonary hydatid cysts, the thoracic surgeon should forgo cystotomy and capitonnage in favor of cystectomy with a wide resection and reconstruction of surrounding tissues. Postoperatively, patients should adhere to a regimen of anthelmintic therapy.

Valor pronóstico del receptor del factor de crecimiento epitelial, factor de crecimiento endotelial vascular, E-cadherina, y p120 catenina en el carcinoma de pulmón no microcítico resecado / Prognostic Value of Epithelial Growth Factor Receptor, Vascular Endothelial Growth Factor, E-Cadherin, and p120 Catenin in Resected Non-Small Cell Lung Carcinoma

Introducción: Para predecir el pronóstico del cáncer de pulmón se han investigado varios marcadores. Enel presente estudio, mediante inmunohistoquímica se investigaron los valores pronósticos de la expresióndel receptor del factor de crecimiento epitelial (EGFR), factor de crecimiento endotelial vascular (VEGF),E-cadherina y p120 catenina en pacientes con un carcinoma de pulmón no microcítico (CPNM) sometidosa resección quirúrgica.Pacientes y métodos: Se determinó prospectivamente la expresión de EGFR, VEGF, E-cadherina y p120catenina en muestras resecadas de pacientes con CPNM que se habían sometido a cirugía entre 2003 y2007. Se registraron las características generales de los pacientes y relacionadas con la enfermedad y latasa de supervivencia.Resultados: En el estudio se incluyeron 170 pacientes con una edad media de 61,3 años. Después de unseguimiento medio de 27,5 meses, se determinó que la supervivencia mediana era de 44,0 meses y latasa de supervivencia a 5 años era del 46,2%. En los grupos con una tinción negativa y positiva, la tasa desupervivencia a los 5 años fue la siguiente: 32 y 66,7% para la expresión de EGFR (p = 0,02), 37,8 y 50,7%para la de VEGF (p = 0,5), 41 y 66% para la de E-cadherina (p = 0,19), 46 y 50% para la de p120 catenina(p = 0,27). El grado de diferenciación del tumor, estado de N, estadio y tinción de EGFR fueron variablesque afectaron significativamente a la supervivencia (p = 0,001, 0,006, 0,03 y 0,02, respectivamente). Enel análisis multivariante de Cox, el nivel de tinción de EGFR y el estado de N fueron las variables queafectaron significativamente a la supervivencia (p = 0,021 y p = 0,010).Conclusiones: Aunque la tinción negativa de EGFR se relacionó con una supervivencia desfavorable, latinción de VEGF, E-cadherina y p120 catenina no se ha relacionado con la supervivencia en pacientes conCPNM resecado(AU)

Introduction: Several markers have been investigated to predict the prognosis of lung cancer. In the presentstudy, the prognostic values of epithelial growth factor receptor (EGFR), vascular endothelial growthfactor (VEGF), E-cadherin, and p120 catenin expression were investigated by immunohistochemistry inpatients with a surgically resected non-small cell lung carcinoma (NSCLC).Patients and method: EGFR, VEGF, E-cadherin, and p120 catenin expression were prospectively determinedin resected specimens from patients with NSCLC who had undergone surgery between 2003 and 2007. Patients’ and disease-related general characteristics and survival rate were recorded. Results: One hundred seventeen patients with a mean age of 61.3 years were included in the study. Aftera mean follow-up of 27.5 months, the median survival was determined to be 44.0 months and the 5-yearsurvival was 46.2%. The 5-year survival in negative and positive staining groups were as follows; 32% and66.7% for EGFR (p = 0.02), 37.8% and 50.7% for VEGF (p = 0.5), 41% and 66% for E-cadherin (p = 0.19), 46%and 50% for p120 catenin (p = 0.27). The differentiation, N status, stage and EGFR staining were variablessignificantly affecting survival (p = 0.001, 0.006, 0.03 and 0.02 respectively). In multivariate Cox analysis,the EGFR staining level and N status were variables those significantly affecting survival (p = 0.021 andp = 0.010).Conclusions: While negative staining of EGFR was related with poor survival, staining of VEGF, E-cadherin,and p120 catenin were not related with survival in patients with resected NSCLC(AU)