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PURPOSE: The purpose of this study was to report the clinical outcome of revision arthroscopic triangular fibrocartilage complex (TFCC) foveal repair using a one-tunnel transosseous suture technique after failed primary TFCC repair. METHODS: Consecutive patients treated with arthroscopic TFCC foveal repair using the uniform one-tunnel transosseous suture technique after failed TFCC repair from 2014 to 2018 were retrospectively reviewed. The clinical outcome was evaluated using the Modified Mayo Wrist Score (MMWS) and the Quick Disabilities of the Arm, Shoulder, and Hand (Quick-DASH) score. The Visual Analog Scale (VAS) for pain, stability of the distal radioulnar joint (DRUJ), grip strength, and active range of motion (ROM) of the wrist joint also were assessed. RESULTS: This study cohort consisted of eight patients, and their mean time to revision after initial surgery was 15.1 months. Previous surgeries were performed using an arthroscopy-assisted mini-open TFCC repair in six cases, an arthroscopic all-inside repair in one case, and an arthroscopic transosseous suture technique in the remaining case. After revisional TFCC foveal repair, all patients demonstrated improved pain and a stable DRUJ. Participants showed improvement in grip strength and mean active wrist ROM. There was improvement in MMWS (from 58.6 to 87.5) and Quick-DASH score (from 46.9 to 12.2) during the mean follow-up of 15.6 months (range: 8-36 months). CONCLUSION: Based on the results of this study, remaining ulnar TFCC remnants may be appropriate for sufficient stable repair using an arthroscopic one-tunnel transosseous suture technique after failed primary repair. However, only a small number of patients was examined. A larger number has to be investigated to confirm the promising preliminary results. LEVEL OF EVIDENCE: Level IV, therapeutic case series.
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Fibrocartílago Triangular , Traumatismos de la Muñeca , Artroscopía , Humanos , Estudios Retrospectivos , Técnicas de Sutura , Suturas , Fibrocartílago Triangular/cirugía , Traumatismos de la Muñeca/cirugía , Articulación de la Muñeca/cirugíaRESUMEN
Rotating cylindrical stamp-based nanoimprint technique has many advantages, including the continuous fabrication of intriguing micro/nanostructures and rapid pattern transfer on a large scale. Despite these advantages, the previous nanoimprint lithography has rarely been used for producing sophisticated nanoscale patterns on a non-planar substrate that has many extended applications. Here, the simple integration of nanoimprinting process with a help of a transparent stamp wrapped on the cylindrical roll and UV optical source in the core to enable high-throughput pattern transfer, particularly on a fabric substrate is demonstrated. Moreover, as a functional resin material, this innovative strategy involves a synergistic approach on the synthesis of molecularly imprinted polymer, which are spatially organized free-standing perforated nanostructures such as nano/microscale lines, posts, and holes patterns on various woven or nonwoven blank substrates. The proposed materials can serve as a self-encoded filtration medium for selective separation of formaldehyde molecules. It is envisioned that the combinatorial fabrication process and attractive material paves the way for designing next-generation separation systems in use to capture industrial or household toxic substances.
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Polímeros Impresos Molecularmente , Nanoestructuras , ImpresiónRESUMEN
OBJECTIVE: The purpose of this study was to identify the location of lunate chondromalacia and to compare the difference in location according to presence or absence of triangular fibrocartilage complex (TFCC) foveal tear, which induces distal radioulnar joint (DRUJ) instability. METHODS: We performed a retrospective study of 97 patients (102 wrists) who were diagnosed with and treated for idiopathic ulnar impaction syndrome (UIS) between 2014 and 2018. Subjects were divided into two groups according to presence or absence of TFCC foveal tear with DRUJ instability. Group I had UIS without a TFCC foveal tear (52 wrists, mean age of 43.2 years), while Group II had UIS with a TFCC foveal tear (50 wrists, mean age of 45.3 years). There was no significant difference in age, sex, or duration of symptoms between the two groups. All patients underwent wrist MR Arthrography (MRA) in the same gantry, and all scanned coronal sections of the lunate were standardized into 10 slices, including the whole anteroposterior width of the lunate. Each slice was sequentially numbered from dorsal to volar side, and the location of chondromalacia was marked in each numbered section. Radiological parameters including ulnar variance and ulnolunate distance (ULD), which indicated the distance between the ulnar head and lunate, were measured in the wrist series. RESULTS: The most frequent location of lunate chondromalacia was slightly to the volar side of the lunate in both groups. Group I showed a higher frequency of chondromalacia in the volar side of the lunate. In Group II, chondromalacia was identified with high frequency not only on the volar side of the lunate but also on the dorsal side. In other words, Group II showed broader chondromalacia in the lunate. There was no significant difference in ulnar variance (Group I, 3.19 ± 1.42 mm; Group II, 2.76 mm ± 1.67 mm) or ulnolunate distance (Group I, 1.66 ± 0.94 mm; Group II, 2.05 mm ± 0.87 mm). The average ULD decreased during radial deviation but increased during ulnar deviation. CONCLUSION: This study showed that lunate chondromalacia associated with idiopathic ulnar impaction syndrome occurs more frequently on the volar side of the lunate. Also, TFCC foveal tear, which causes DRUJ instability, leads to broader lunate chondromalacia in idiopathic ulnar impaction syndrome. Therefore, further analysis of the pattern of lunate chondromalacia can provide a clue for DRUJ instability.
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Enfermedades de los Cartílagos , Fibrocartílago Triangular , Traumatismos de la Muñeca , Adulto , Enfermedades de los Cartílagos/diagnóstico por imagen , Humanos , Persona de Mediana Edad , Estudios Retrospectivos , Fibrocartílago Triangular/diagnóstico por imagen , Traumatismos de la Muñeca/diagnóstico por imagen , Articulación de la Muñeca/diagnóstico por imagenRESUMEN
OBJECTIVE: To assess whether a proximal ligamentous component (PLC) of the triangular fibrocartilage complex (TFCC) with a distally prolapsing morphology is associated with the presence of a TFCC foveal tear on arthroscopy. METHODS: One-hundred thirty-two patients (134 wrists) who underwent MR arthrography and subsequent wrist arthroscopy between September 2014 and March 2018 were retrospectively evaluated. The degree of distal PLC prolapse was measured on coronal MR arthrography using the height-to-length ratio (HLR). Subjects' demographics, ulnar variance, presence of a degenerative TFCC tear, and ulnar styloid nonunion were assessed. The association between specific variables and the presence of a foveal tear was investigated. RESULTS: A TFCC foveal tear was identified in a total of 101 of 134 wrists examined by arthroscopy. Univariable analysis showed that the HLR of the PLC was significantly greater in the foveal tear group compared with the intact fovea group (44.6 vs. 38.9%, respectively, p < 0.001). Multivariable analysis showed that HLR was positively associated with a foveal tear (odds ratio [OR], 1.211; p < 0.001). The estimated cut-off value of the HLR was 41% (area under the curve [AUC] 0.77). CONCLUSIONS: PLCs with a distal prolapse pattern and large HLR are associated with TFCC foveal tears. The HLR of the PLC measured on coronal MR images can therefore be used as an additional predictor of tears of the foveal attachment of the TFCC.
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Artrografía/métodos , Imagen por Resonancia Magnética/métodos , Fibrocartílago Triangular/diagnóstico por imagen , Traumatismos de la Muñeca/diagnóstico por imagen , Adulto , Femenino , Humanos , Masculino , Estudios Retrospectivos , Cúbito/diagnóstico por imagenRESUMEN
PURPOSE: To compare outcomes at different time periods following arthroscopic triangular fibrocartilage complex (TFCC) transosseous foveal repair within 6 months, between 6 and 12 months, and more than 12 months from injury. METHODS: Consecutive patients treated with arthroscopic TFCC foveal repair using the uniform one-tunnel transosseous suture technique by a surgeon from 2014 to 2017 were retrospectively reviewed. The patients were assigned to 1 of 3 groups according to time between injury and surgery. Pain visual analog scale (VAS); grip strength; modified Mayo wrist score (MMWS); Quick disabilities of the arm, shoulder, and hand (QuickDASH) score; and distal radioulnar joint stability were assessed at minimum 2 years postoperatively, along with minimal clinically important difference, and overall patient satisfaction. RESULTS: This study cohort consisted of 80 patients: group A (<6 months, n = 38), group B (6-12 months, n = 20), and group C (>12 months, n = 22). No differences were found among groups in VAS, grip strength, and MMWS and QuickDASH. Overall, patients exhibited significant functional improvement at 2 years (VAS: 3-0, P < .001; grip strength: 77.1%-95.6%, P < .001; MMWS: 65-90, P < .001, QuickDASH: 20.5-4.5, P < .001). Median changes in outcome variables and the proportion of patients achieving minimal clinically important difference for the QuickDASH were similar among groups. Seventy-eight patients (97%) achieved distal radioulnar joint stability, and 70 patients (87%) were satisfied with treatment. CONCLUSIONS: Although this current study has insufficient statistical power, the available data suggest that patients with a TFCC foveal tear who underwent arthroscopic transosseous repair surgery more than 12 months after injury could expect to experience similar functional improvement compared with patients who underwent surgery within 6 months or between 6 and 12 months following injury. LEVEL OF EVIDENCE: Level III, retrospective comparative study.
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Artroscopía/métodos , Técnicas de Sutura , Tiempo de Tratamiento , Fibrocartílago Triangular/lesiones , Fibrocartílago Triangular/cirugía , Adulto , Femenino , Humanos , Masculino , Diferencia Mínima Clínicamente Importante , Dimensión del Dolor , Recuperación de la Función , Estudios Retrospectivos , Adulto JovenRESUMEN
Detecting earthquakes using smartphones or IoT devices in real-time is an arduous and challenging task, not only because it is constrained with the hard real-time issue but also due to the similarity of earthquake signals and the non-earthquake signals (i.e., noise or other activities). Moreover, the variety of human activities also makes it more difficult when a smartphone is used as an earthquake detecting sensor. To that end, in this article, we leverage a machine learning technique with earthquake features rather than traditional seismic methods. First, we split the detection task into two categories including static environment and dynamic environment. Then, we experimentally evaluate different features and propose the most appropriate machine learning model and features for the static environment to tackle the issue of noisy components and detect earthquakes in real-time with less false alarm rates. The experimental result of the proposed model shows promising results not only on the given dataset but also on the unseen data pointing to the generalization characteristics of the model. Finally, we demonstrate that the proposed model can be also used in the dynamic environment if it is trained with different dataset.
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In this article, we describe a facile method to fabricate MIP patterns in specifically designed microfluidic channels. With this design, homogenous and stable MIP films were spatially immobilized inside the patterned PDMS channels. In this system, the fluorescent response was identified by detection of the fluorescence-labeled bovine serum albumin (BSA) template. In comparison, non-imprinted polymer (NIP) was also prepared. From the results of fluorescent response, significant binding behaviors of BSA molecules into the cavities of MIP patterns was observed due to the increased residence time in each ancillary hexagonal channel caused by the turbulent flow. However, the NIP patterns did not show the fluorescent response. Thus, the use of this system provides effective MIP-based microfluidic channels for the application of biosensors.
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Técnicas Biosensibles , Impresión Molecular , Microfluídica , Polímeros , Albúmina Sérica BovinaRESUMEN
PURPOSE: An articular depressed fragment at the base of the middle phalanx can be an obstacle to congruent reduction and stable fixation. This study assessed the outcomes of a transosseous reduction technique combined with locking plate fixation for the treatment of articular depressed middle phalangeal base fracture. METHODS: Between 2015 and 2017, seven patients (eight fingers) with intraarticular comminuted middle phalangeal base fracture were included in this study. Mean follow-up was 19 months (range 12-30 months). All patients showed depression of the articular fragment on sagittal computed tomography (CT) scan and were treated with a transosseous reduction technique and dorsal locking plate fixation. Radiographic evaluation was performed to ensure restoration of a concentric articular surface postoperatively. Total active range of motion (TAM) of the finger, grip strength, and the quick Disabilities of the Arm, Shoulder and Hand (quick DASH) score were evaluated at the last follow-up. Complications were also assessed. RESULTS: All fractures obtained bony union with a concentric joint. There was no significant loss of reduction during the follow-up period. The mean active proximal interphalangeal (PIP) joint and distal interphalangeal joint motion arcs at follow-up were 89° and 61°, respectively. Mean TAM of the affected finger and mean grip strength were 94% (range 80-100%) and 94% (range 86-100%) of the contralateral side, respectively. Mean quick DASH score was 2.3 (range 0-9.1). All patients returned to work. No surgery-related complications occurred. CONCLUSIONS: This technique provides satisfactory restoration of articular congruence and enables the early joint mobilization of articular depression-type fractures of the base of the middle phalanx. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic, level IV.
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Placas Óseas , Traumatismos de los Dedos/cirugía , Fijación Interna de Fracturas , Fracturas Conminutas/cirugía , Estudios de Cohortes , Fijación Interna de Fracturas/instrumentación , Fijación Interna de Fracturas/métodos , HumanosRESUMEN
The conversion of graphene oxide (GO) into reduced graphene oxide (rGO) is imperative for the electronic device applications of graphene-based materials. Efficient and cost-effective fabrication of highly uniform GO films and the successive reduction into rGO on a large area is still a cumbersome task through conventional protocols. Improved film casting of GO sheets on a polymeric substrate with quick and green reduction processes has a potential that may establish a path to the practical flexible electronics. Herein, we report a facile deposition process of GO on flexible polymer substrates to create highly uniform thin films over a large area by a flow-enabled self-assembly approach. The self-assembly of GO sheets was successfully performed by dragging the trapped solution of GO in confined geometry, which consisted of an upper stationary blade and a lower moving substrate on a motorized translational stage. The prepared GO thin films could be selectively reduced and facilitated from the simple laser direct writing process for programmable circuit printing with the desired configuration and less sample damage due to the non-contact mode operation without the use of photolithography, toxic chemistry, or high-temperature reduction methods. Furthermore, two different modes of the laser operating system for the reduction of GO films turned out to be valuable for the construction of novel graphene-based high-throughput electrical circuit boards compatible with integrating electronic module chips and flexible humidity sensors.
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The work presented here introduces a facile strategy for the development of flexible and stretchable electrodes that harness the robust characteristics of carbon nanomaterials through laser processing techniques on a liquid crystal polymer (LCP) film. By utilizing LCP film as a biocompatible electronic substrate, control is demonstrated over the laser irradiation parameters to achieve efficient pattern generation and transfer printing processes, thereby yielding highly conductive laser-induced graphene (LIG) bioelectrodes. To enhance the resolution of the patterned LIG film, shadow masks are employed during laser scanning on the LCP film surface. This approach is compatible with surface-mounted device integration, enabling the circuit writing of LIG/LCP materials in a flexible format. Moreover, kirigami-inspired on-skin bioelectrodes are introduced that exhibit reasonable stretchability, enabling independent connections to healthcare hardware platforms for electrocardiogram (ECG) and electromyography (EMG) measurements. Additionally, a brain-interfaced LIG microelectrode array is proposed that combines mechanically compliant architectures with LCP encapsulation for stimulation and recording purposes, leveraging their advantageous structural features and superior electrochemical properties. This developed approach offers a cost-effective and scalable route for producing patterned arrays of laser-converted graphene as bioelectrodes. These bioelectrodes serve as ideal circuit-enabled flexible substrates with long-term reliability in the ionic environment of the human body.
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Grafito , Polímeros , Humanos , Grafito/química , Reproducibilidad de los Resultados , Electrodos , Microelectrodos , Encéfalo , Rayos LáserRESUMEN
OBJECTIVES: To analyze the risk factors associated with postoperative flexor tendon rupture, after a volar plate fixation of distal radius fractures. DESIGN: Retrospective observational case-control study. SETTING: Tertiary Care University Hospital in the Republic of Korea (2009-2020). PATIENTS: Sixteen referred patients were treated for flexor tendon rupture, following previously performed volar plating of distal radius fractures at other institutions. 16 patients were randomly selected from our database as controls, and were matched based on the Soong grade of the case group. INTERVENTION: Not applicable. MAIN OUTCOME MEASUREMENTS: Radial tilt and radial height were measured on anteroposterior radiographs. The volar tilt, tear drop angle, carpal translation, and Soong grade were measured in a lateral view. RESULTS: Quantitative measurements of the volar tilt, carpal translation, and tear drop angle were positively correlated with the flexor tendon rupture. The mean volar tilt and tear drop angle in the tendon rupture group were significantly smaller than those in the control group. The mean carpal translation in the tendon rupture group was significantly greater than that in the control group. CONCLUSIONS: This study demonstrated that volar tilt, carpal translation, and tear drop angle are significant risk factors for flexor tendon rupture, especially for plates placed at Soong grade 1 or 2. We suggest that the potential for tendon rupture because of incomplete reduction of the distal radius fracture along with implant prominence volar to the watershed line aggravates flexor tendon irritation at the distal edge of the plate because of distorted flexor tendon paths. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
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Fracturas del Radio , Traumatismos de los Tendones , Fracturas de la Muñeca , Humanos , Placas Óseas/efectos adversos , Estudios de Casos y Controles , Fijación Interna de Fracturas/efectos adversos , Fracturas del Radio/diagnóstico por imagen , Fracturas del Radio/cirugía , Fracturas del Radio/complicaciones , Estudios Retrospectivos , Factores de Riesgo , Rotura/etiología , Traumatismos de los Tendones/diagnóstico por imagen , Traumatismos de los Tendones/epidemiología , Traumatismos de los Tendones/etiología , TendonesRESUMEN
Small-scale and high-performance energy storage devices have drawn tremendous attention with their portable, lightweight, and multi-functionalized features. Here, we present a foldable supercapacitor with affordable flexibility by adopting a developed design and electrode material system as a way to extend usability. Notably, to resolve the limited energy density of conventional capacitors, we successfully synthesize the CoO/NiCo-layered double hydroxide (LDH) core-shell nanostructure on Ni framework as a cathode material. Further, glucose-based activated carbon (GBAC) is utilized for the anode. The CoO/NiCo-LDH electrodes exhibited a high specific capacitance of â¼284.8 mAh g-1 at 1 A g-1, and GBAC delivers a high specific capacitance of â¼166 F g-1 at 1 A g-1. In the following, the combinatorial integration of these materials enabled the asymmetric supercapacitor (ASC) to increase the energy density by enhancing the capacitance and the voltage window, in which a hydrogel-based electrolyte was facilitated for the foldable and wearable capability. The energy density of the ASC device was â¼24.9 Wh kg-1 at a power density of â¼779.5 W kg-1 with a voltage window of â¼1.6 V. As demonstrated, a self-powered energy source was demonstrated by a serially connected multi-ASC device with a help of a commercial solar cell, which was employed for powering wearable healthcare monitoring devices, including personal alarms for patients and recording the human body's electrical signals. The present work offers a viable approach to preparing potential candidates for high-performance electrodes of supercapacitors with deformable configurations to extend the powering capability of other electronic devices with physical functionalities used in wearable electronics.
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Carbón Orgánico , Dispositivos Electrónicos Vestibles , Humanos , Capacidad Eléctrica , Electricidad , Electrodos , GlucosaRESUMEN
BACKGROUND: Wrist pain on the ulnar side is often caused by ulnar impaction syndrome (UIS). Idiopathic UIS requires surgical treatment when conservative treatment fails. The 2 main surgical procedures used are the wafer procedure and ulnar shortening osteotomy (USO) of the metaphysis or diaphysis. This review aimed to analyze comparative studies of the 2 procedures in UIS to determine clinical outcomes and complications. METHODS: One prospective and 5 retrospective comparison trials were retrieved from the PubMed, Embase, and Cochrane Library databases. The primary outcomes were treatment effectiveness; pain visual analog scale (VAS), disabilities of the arm, shoulder, and hand (DASH) score, Mayo wrist, and Darrow scores. The incidence of postoperative complications formed the secondary outcome. RESULTS: The selected studies included 107 patients who underwent the wafer procedure (G1) and 117 patients who underwent USO (G2). The wafer procedure had the benefits of less postoperative immobilization and an early return to work. However, there were no significant differences in the postoperative pain improvement and functional scores. All 6 studies reported high total complication rates and reoperation with USO. The most frequent complication was implant-related discomfort or irritation; subsequent plate removal was the most common reason for a secondary operation. CONCLUSIONS: There was no difference in pain improvement or the postoperative functional score between the groups. Nevertheless, postoperative complications were the major pitfalls of USO. As the specialized shortening system advances further, a high-level study will be necessary to determine the surgical option in UIS.
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Artropatías , Humanos , Estudios Retrospectivos , Estudios Prospectivos , Artropatías/cirugía , Articulación de la Muñeca/cirugía , Osteotomía/efectos adversos , Osteotomía/métodos , Resultado del Tratamiento , Artralgia/etiología , Artralgia/cirugía , Complicaciones Posoperatorias/epidemiologíaRESUMEN
Molecularly imprinted polymers (MIPs) have garnered significant attention as a promising material for engineering specific biological receptors with superior chemical complementarity to target molecules. In this study, we present an electrochemical biosensing platform incorporating MIP films for the selective detection of the interleukin-1ß (IL-1ß) biomarker, particularly suitable for mobile point-of-care testing (POCT) applications. The IL-1ß-imprinted biosensors were composed of poly(eriochrome black T (EBT)), including an interlayer of poly(3,4-ethylene dioxythiophene) and a 4-aminothiophenol monolayer, which were electrochemically polymerized simultaneously with template proteins (i.e., IL-1ß) on custom flexible screen-printed carbon electrodes (SPCEs). The architecture of the MIP films was designed to enhance the sensor sensitivity and signal stability. This approach involved a straightforward sequential-electropolymerization process and extraction for leaving behind cavities (i.e., rebinding sites), resulting in the efficient production of MIP-based biosensors capable of molecular recognition for selective IL-1ß detection. The electrochemical behaviors were comprehensively investigated using cyclic voltammograms and electrochemical impedance spectroscopy responses to assess the imprinting effect on the MIP films formed on the SPCEs. In line with the current trend in in vitro diagnostic medical devices, our simple and effective MIP-based analytical system integrated with mobile POCT devices offers a promising route to the rapid detection of biomarkers, with particular potential for periodontitis screening.
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Técnicas Biosensibles , Impresión Molecular , Polímeros Impresos Molecularmente , Polímeros/química , Interleucina-1beta , Sistemas de Atención de Punto , Impresión Molecular/métodos , Carbono/química , Técnicas Biosensibles/métodos , Electrodos , Técnicas Electroquímicas/métodos , Límite de DetecciónRESUMEN
Optical gain enhancement of two-dimensional CsPbBr3 nanosheets was studied when the amplified spontaneous emission is guided by a patterned structure of polyurethane-acrylate. Given the uncertainties and pitfalls in retrieving a gain coefficient from the variable stripe length method, a gain contour [Formula: see text] was obtained in the plane of spectrum energy (âω) and stripe length (x), whereby an average gain was obtained, and gain saturation was analysed. Excitation and temperature dependence of the gain contour show that the waveguide enhances both gain and thermal stability due to the increased optical confinement and heat dissipation, and the gain origins were attributed to the two-dimensional excitons and the localized states.
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As a new concept in materials design, a variety of strategies have been developed to fabricate optical microlens arrays (MLAs) that enable the miniaturization of optical systems on the micro/nanoscale to improve their characteristic performance with unique optical functionality. In this paper, we introduce a cost-effective and facile fabrication process on a large scale up to ~15 inches via sequential lithographic methods to produce thin and deformable hexagonally arranged MLAs consisting of polydimethylsiloxane (PDMS). Simple employment of oxygen plasma treatment on the prestrained MLAs effectively harnessed the spontaneous formation of highly uniform nanowrinkled structures all over the surface of the elastomeric microlenses. With strain-controlled tunability, unexpected optical diffraction patterns were characterized by the interference combination effect of the microlens and deformable nanowrinkles. Consequently, the hierarchically structured MLAs presented here have the potential to produce desirable spatial arrangements, which may provide easily accessible opportunities to realize microlens-based technology by tunable focal lengths for more advanced micro-optical devices and imaging projection elements on unconventional security substrates.
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Several studies have reported changes in the prevalence of childhood fractures between the prepandemic and coronavirus disease 2019 pandemic periods considering the overall decrease in activity during the latter. This review aimed to organize and summarize the global trends in pediatric fracture incidence. Our findings should help predict fracture patterns in the postpandemic period by identifying changes in the past and present, thus aiding patient management.
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Photobiomodulation (PBM) has received attention due to its potential for improving tissue function and enhancing regeneration in stroke. A lightweight, compact, and simple system of miniaturized electronic devices consisting of packaged light-emitting diodes (LEDs) that incorporates a flexible substrate for in vivo brain PBM in a mouse model is developed. Using this device platform, the preventive and therapeutic effects of PBM affixed to the exposed skull of mice in the photothrombosis and middle cerebral artery occlusion stroke model are evaluated. Among the wavelength range of 630, 850, and 940 nm LED array, the PBM with 630-nm LED array is proved to be the most effective for reducing the infarction volume and neurological impairment after ischemic stroke. Moreover, the PBM with 630 nm LED array remarkably improves the capability of spatial learning and memory in the chronic poststroke phase, attenuates AIM2 inflammasome activation and inflammasome-mediated pyroptosis, and modulates microglial polarization in the hippocampus and cortex 7 days following ischemic stroke. Thus, PBM may prevent tissue and functional damage in acute ischemic injury, thereby attenuating the development of cognitive impairment after stroke.
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Accidente Cerebrovascular Isquémico , Terapia por Luz de Baja Intensidad , Accidente Cerebrovascular , Animales , Inflamasomas , Ratones , CráneoRESUMEN
Wound healing is the dynamic tissue regeneration process replacing devitalized and missing tissue layers. With the development of photomedicine techniques in wound healing, safe and noninvasive photobiomodulation therapy is receiving attention. Effective wound management in photobiomodulation is challenged, however, by limited control of the geometrical mismatches on the injured skin surface. Here, adhesive hyaluronic acid-based gelatin nanofibrous membranes integrated with multiple light-emitting diode (LED) arrays are developed as a skin-attachable patch. The nanofibrous wound dressing is expected to mimic the three-dimensional structure of the extracellular matrix, and its adhesiveness allows tight coupling between the wound sites and the flexible LED patch. Experimental results demonstrate that our medical device accelerates the initial wound healing process by the synergetic effects of the wound dressing and LED irradiation. Our proposed technology promises progress for wound healing management and other biomedical applications.
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Triboelectric nanogenerators (TENGs) are put forward as a state-of-the-art energy-scavenging technology for self-powered electronics, but their severe wear and degradation driven by inevitable friction can pose significant durability and sustainability concerns. Here, an array of microfibers is reported that functions as a robust and sustainable TENG in both in-plane sliding and vertical contact-separation modes, with excellent electrical potential as high as 20 V and a high cyclability of 3000. The design flexibility of this microbrush TENG (MB-TENG) on the counter materials facilitates the further improvement of electrical outputs, benefiting numerous applications of human-interactive triboelectrification. Significantly, these MB-TENGs offer sufficient output power for successfully driving a smartwatch as well as an electromyography module. This technology uses a simple and cost-effective manner to provide a robust and reliable monolithic TENG module, which is expected to serve as a promising energy-harvesting source for self-powered electronics in the near future.