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1.
Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium.
Chem Res Toxicol
; 33(1): 7-9, 2020 01 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31909603
2.
Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
Pharm Res
; 37(10): 194, 2020 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32918191
3.
Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors.
Bioorg Med Chem Lett
; 29(3): 406-412, 2019 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30587449
4.
Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.
Mol Pharmacol
; 89(5): 492-504, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26893303
5.
Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases.
Pharm Res
; 32(6): 2060-71, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25522789
6.
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.
Drug Metab Dispos
; 42(8): 1301-13, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24855184
7.
Assessing the Impact of Immunogenicity and Improving Prediction of Trough Concentrations: Population Pharmacokinetic Modeling of Adalimumab in Patients with Crohn's Disease and Ulcerative Colitis.
Clin Pharmacokinet
; 62(4): 623-634, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36905528
8.
Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media.
Pharmaceutics
; 14(4)2022 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35456533
9.
Collecting antibodies and large molecule biomarkers in mouse interstitial brain fluid: a comparison of microdialysis and cerebral open flow microperfusion.
MAbs
; 13(1): 1918819, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33993834
10.
Quantitative Systems Pharmacology Model for Alzheimer Disease Indicates Targeting Sphingolipid Dysregulation as Potential Treatment Option.
CPT Pharmacometrics Syst Pharmacol
; 7(11): 759-770, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30207429
11.
IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results.
Eur J Pharm Sci
; 96: 610-625, 2017 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27816631
12.
IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds.
Eur J Pharm Sci
; 96: 598-609, 2017 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27671970
13.
A retrospective evaluation of species-specific sensitivity for neurological signs in toxicological studies: Is the dog more sensitive than the non-human primate?
Toxicol Lett
; 243: 78-87, 2016 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-26732424
14.
An inter-laboratory study to evaluate the effects of medium composition on the differentiation and barrier function of Caco-2 cell lines.
Altern Lab Anim
; 33(6): 603-18, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16372835
15.
High-throughput quantitative and qualitative analysis of microsomal incubations by cocktail analysis with an ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometer system.
Bioanalysis
; 7(6): 671-83, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25517264
16.
Hydroxyl radicals release in rat striatum involves metabotropic glutamate receptors.
Brain Res Bull
; 61(4): 453-7, 2003 Aug 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-12909289
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