An Overview of Scientific Reproducibility: Consideration of Relevant Issues for Behavior Science/Analysis.

For over a decade, the failure to reproduce findings in several disciplines, including the biomedical, behavioral, and social sciences, have led some authors to claim that there is a so-called "replication (or reproducibility) crisis" in those disciplines. The current article examines: (a) various aspects of the reproducibility of scientific studies, including definitions of reproducibility; (b) published concerns about reproducibility in the scientific literature and public press; (c) variables involved in assessing the success of attempts to reproduce a study; (d) suggested factors responsible for reproducibility failures; (e) types of validity of experimental studies and threats to validity as they relate to reproducibility; and (f) evidence for threats to reproducibility in the behavior science/analysis literature. Suggestions for improving the reproducibility of studies in behavior science and analysis are described throughout.

Gamma-hydroxybutyrate (GHB) reduces operant behavior without impairing working memory in rats responding under fixed-consecutive-number schedules.

The use of gamma-hydroxybutyrate (GHB), a therapeutic agent and recreational drug, has increased since the late 1990s. Researchers have primarily studied GHB's neurochemical, discriminative, and reinforcing effects, but little is known about the drug's effects on learning, memory, or other complex behavioral processes. This study examined the acute and chronic effects of GHB in rats responding under fixed-consecutive-number (FCN) schedules, which assess working memory. Additionally, we examined stimulus control and response effort as modulators of GHB's effects. GHB dose-dependently reduced operant activity and response rates, but tolerance developed to these effects. GHB had no effect on accuracy or efficiency (i.e., working memory). Stimulus control and response effort did not modulate GHB's effects. These results suggest that GHB produced non-selective behavioral disruption but not working memory impairment.

Simplified Approach Charts Improve Data Retrieval Performance.

The effectiveness of different instrument approach charts to deliver minimum visibility and altitude information during airport equipment outages was investigated. Eighteen pilots flew simulated instrument approaches in three conditions: (a) normal operations using a standard approach chart (standard-normal), (b) equipment outage conditions using a standard approach chart (standard-outage), and (c) equipment outage conditions using a prototype decluttered approach chart (prototype-outage). Errors and retrieval times in identifying minimum altitudes and visibilities were measured. The standard-outage condition produced significantly more errors and longer retrieval times versus the standard-normal condition. The prototype-outage condition had significantly fewer errors and shorter retrieval times than did the standard-outage condition. The prototype-outage condition produced significantly fewer errors but similar retrieval times when compared with the standard-normal condition. Thus, changing the presentation of minima may reduce risk and increase safety in instrument approaches, specifically with airport equipment outages.

Response acquisition with immediate and delayed conditioned reinforcement.

Groups comprising eight rats initially were exposed to response-independent water deliveries, then to conditions under which a lever-press response raised an empty dipper immediately or after a resetting delay of 15, 30, or 45 s. When their performance was compared to that of control animals using a 90% confidence level, six rats in the immediate-reinforcement group met the primary criterion for response acquisition during a single 6-h session; 4, 4, and 3 did so in the 15, 30, and 45 s delay groups, respectively. Similar evidence of acquisition was obtained when a 95% confidence level was used. With a 99% confidence level, however, evidence of acquisition was not compelling. Although these data appear to provide the first demonstration of response acquisition in the absence of handshaping or autoshaping under conditions where the putative reinforcer is both conditioned and delayed, they also demonstrate that whether response acquisition occurs depends, in part, on how it is defined.

MDMA and performance under a progressive-ratio schedule of water delivery.

This study investigated the possible motivational effects of (+-)3,4-methylenedioxymethamphetamine (MDMA, ecstasy) in water-deprived rats responding under a progressive-ratio 2 schedule of water delivery. Lower doses (1.0 and 1.8 mg/kg i.p.) had inconsistent effects on breakpoints and response rates, whereas higher doses (3.2 and 5.6 mg/kg ip) significantly decreased both response measures relative to vehicle control levels. Increasing the level of water restriction significantly increased both response measures, and decreasing restriction significantly decreased both response measures. This study found no evidence that MDMA increased the reinforcing efficacy of water, although prior findings have suggested that the drug might have such an effect. MDMA-induced changes in motor activity may account for the present results.

The effects of behavioral history on response acquisition with immediate and delayed reinforcement.

Effects of prior exposure to the experimental chamber with levers present or absent and variable-time (VT) 60-s water deliveries arranged during one, five, or no 1-hr sessions were examined in rats during a 6-hr response-acquisition session in which presses on one lever produced water delivery immediately or after a 15-s resetting delay, and presses on the other lever canceled scheduled water deliveries. Response acquisition was (a) slower to occur when water deliveries were delayed, (b) most consistent in groups that had received five VT sessions, and (c) impaired by the presence of levers only when there had been five VT sessions and water deliveries were delayed during the acquisition session.

Motivating operations and terms to describe them: some further refinements.

Over the past decade, behavior analysts have increasingly used the term establishing operation (EO) to refer to environmental events that influence the behavioral effects of operant consequences. Nonetheless, some elements of current terminology regarding EOs may interfere with applied behavior analysts' efforts to predict, control, describe, and understand behavior. The present paper (a) describes how the current conceptualization of the EO is in need of revision, (b) suggests alternative terms, including the generic term motivating operation (MO), and (c) provides examples of MOs and their behavioral effects using articles from the applied behavior analysis literature.

Cocaine and automaintained responding in pigeons: rate-reducing effects and tolerance thereto with different durations of food delivery.

Pigeons were exposed to an automaintenance procedure in which 6-s key illuminations in one color (red or white) were immediately followed by 3-s food deliveries and key illuminations in the other color were followed by 9-s food deliveries. Both conditions engendered consistent responding. With both durations of food delivery, acute and chronic cocaine administrations (1.0-17.8 mg/kg) produced dose-dependent decreases in mean percent trials (key illuminations) with a response and mean total response per session. Tolerance developed to the disruptive effects of cocaine on both response measures. Food duration did not significantly affect either response measure or significantly interact with cocaine dose or drug regimen. The orderliness of the present findings, like those of a related study examining whether probability of food delivery modulated the effects of cocaine on automaintained responding [Porritt, M., Arnold, M., Poling, A., Cocaine and automaintained responding in pigeons: rate-reducing effects and tolerance thereto with different CS-US pairing probabilities. Pharmacol Biochem Behav 2007; 87:405-411.], suggests that the automaintenance procedure is a useful assay for examining tolerance to drug effects on classically-conditioned responding. Unlike the results of that study, however, the present findings are inconsistent with a behavioral momentum analysis of drug effects on such responding.

The abative effect: A new term to describe the action of antecedents that reduce operant responding.

Behavior-analytic terminology concerning the so-called inhibitory effect of operant antecedents lacks precision. The present paper describes the problem with current nomenclature concerning the effects of antecedent events that reduce operant responding and offers a solution to this problem. The solution consists of adopting a new term, abative, for the effect in question. This paper suggests that the new term has several advantages over terms currently used and that adopting this term will yield a variety of practical and theoretical benefits, including, but not limited to, a more consistent vocabulary to describe antecedent-behavior relations.