Bone microstrain values of 1-piece and 2-piece implants subjected to mechanical loading.

PURPOSE: The purpose of this study was to measure and compare the strain levels in peri-implant bone as generated by 1-piece (1P) and 2-piece (2P) implant systems. MATERIALS AND METHODS: The implants (1P and 2P) were placed into bovine bone according to the manufacturer's protocol. Four linear strain gauges were placed around each implant neck and apex. Each model was loaded in static loading by a material testing machine in ascending forces ranging from 20 to 120 N. Microstrains (µ[Latin Small Letter Open E]) generated in the surrounding bone were measured by a strain gauge and recorded. RESULTS: Recorded microstrains were significantly higher for 1P implants than for 2P implants. Average recorded microstrain values were significantly lower in the neck (71.6 and 17.3 µs) compared with the apical (132 and 60 µs) regions of 1P and 2P implants, respectively (P < 0.0001). CONCLUSIONS: Within the limitations of this study, highest microstrains were generated in apical regions regardless of implant design, but the 2P implant ap-peared to provide a stress-damping effect in both the cervical and apical regions compared with the 1P implant.

Retrospective clinical evaluation of tapered implants: 10-year follow-up of delayed and immediate placement of maxillary implants.

OBJECTIVES: To retrospectively evaluate the clinical outcome of tapered, multithreaded implants (Tapered Screw-Vent MTX; Zimmer Dental, Inc, Carlsbad, CA) with an emphasis on periimplant crestal bone status around those placed delayed and immediately in the posterior and anterior maxilla. METHODS: Chart reviews were performed on 46 patients who had been treated with 173 implants replacing one or more missing and/or unsalvageable teeth in the maxilla. Implant placement and loading was either immediate or delayed. Marginal bone changes were calculated using standardized radiographs taken at implant placement and during annual follow-up. RESULTS: After a mean follow-up of 119 to 121 months, implant survival rate was 99%, and implant success rate was 97%. No discernable bone loss was evident in 85.5% of the surviving implants. Crestal bone loss was observed in 14.5% of all surviving implants: 38.5% of implants immediately loaded and 29.9% of implants with delayed loading. Twenty-one implants exhibited 1 mm of bone loss, 3 implants lost 2 mm, and 1 implant lost 3 mm. Low-density maxillary jawbone and more extensive bone remodeling required around implants immediately placed into extraction sockets were the probable causes of observed bone loss in this study. CONCLUSIONS: Implants exhibited excellent long-term outcomes with little or no bone loss.

Impairments of interpersonal synchrony evident in attention deficit hyperactivity disorder (ADHD).

In addition to well-known attention deficiencies, attention deficit hyperactivity disorder (ADHD) is accompanied by deficiencies in social cognition. Both intentional and spontaneous interpersonal synchrony have been found to be an essential part of successful human interaction. Here, we used a novel paradigm to assess intentional and spontaneous interpersonal synchrony in adults with and without ADHD. Our data indicate that intentional interpersonal synchrony is reduced in ADHD, whereas spontaneous interpersonal synchrony remains intact. These results suggest that a dysfunctional pattern of interpersonal synchrony may account for interpersonal difficulties in ADHD.

Remote immune processes revealed by immune-derived circulating cell-free DNA.

Blood cell counts often fail to report on immune processes occurring in remote tissues. Here, we use immune cell type-specific methylation patterns in circulating cell-free DNA (cfDNA) for studying human immune cell dynamics. We characterized cfDNA released from specific immune cell types in healthy individuals (N = 242), cross sectionally and longitudinally. Immune cfDNA levels had no individual steady state as opposed to blood cell counts, suggesting that cfDNA concentration reflects adjustment of cell survival to maintain homeostatic cell numbers. We also observed selective elevation of immune-derived cfDNA upon perturbations of immune homeostasis. Following influenza vaccination (N = 92), B-cell-derived cfDNA levels increased prior to elevated B-cell counts and predicted efficacy of antibody production. Patients with eosinophilic esophagitis (N = 21) and B-cell lymphoma (N = 27) showed selective elevation of eosinophil and B-cell cfDNA, respectively, which were undetectable by cell counts in blood. Immune-derived cfDNA provides a novel biomarker for monitoring immune responses to physiological and pathological processes that are not accessible using conventional methods.

Influence of Vinyl Polysiloxane Impression Techniques on Marginal Fit of Metal Frameworks for Fixed Partial Dentures.

Impression technique is one of the factors affecting restoration fit accuracy, which is a major aspect influencing its survival. The purpose of this study is to compare, in vivo, the effect of two commonly used Vinyl Polysiloxane (VPS) impression techniques on the metal framework fitting of fixed partial dentures. Ninety-two consecutive patients, diagnosed as partially edentulous, treated by fixed partial denture restorations, participated in the study. Group 1-impressions (n = 44) were subjected to the 1-step technique, while group 2 impressions (n = 48) were subjected the 2-step technique. Three accuracy assessment common methods: probe, tactile sense and radiographic test, were used to validate the clinical fit of the metal framework. Misfit was defined as even one test failure. Twenty-one (22.8%) out of 92 metal frameworks exhibited metal frameworks misfit, whereas the other 71 (77.2%) were found to be accurate. Group 1 presented significantly (p = 0.04) more metal frameworks misfit, 14/44 (31.8%) vs. 7/48 (14.6%). Restoration location (maxilla vs. mandible) had no statistically significant impact on the results (p = 0.461). The use of the VPS putty/wash 2-step impression technique is recommended to improve the clinical fit of fixed partial denture restorations.

Cardiovascular and bone health of former elite infantry soldiers at middle life.

BACKGROUND: The long term implications of elite infantry service on cardiovascular health and cortical bone width at middle age has not been studied. The purpose of this study was to compare the cardiovascular health and cortical bone thickness of former elite infantry soldiers at middle life with a sedentary population of religious scholars using seven factors associated with cardiovascular risk and QCT tibial cross sections 8 cm above the ankle joint. RESULTS: Torah scholars had a higher 5 year risk for a fatal or non fatal cardiovascular event (p = 0.008) than former elite infantry soldiers. The former elite infantry soldiers had wider tibia cortices than Torah scholar (p = 0.003). CONCLUSIONS: This study shows that former elite infantry soldiers who performed strenuous physical activity during their military service and continued physical activity in their subsequent life, had stronger tibias based on increased cortical width and a modest decrease in cardiovascular risk at middle life compared to sedentary Torah scholars.

Group G streptococcal bacteremia in Jerusalem.

Group G Streptococcus (GGS) can cause severe infections, including bacteremia. These organisms often express a surface protein homologous to the Streptococcus pyogenes M protein. We retrospectively studied the characteristics of patients from the Hadassah Medical Center with GGS bacteremia from 1989 to 2000. Ninety-four cases of GGS bacteremia were identified in 84 patients. The median age was 62 years, 54% were males, and 92% had underlying diseases (35% had a malignancy, and 35% had diabetes mellitus). The most frequent source for bacteremia was cellulitis (61%). emm typing of 56 available isolates disclosed 13 different types, including 2 novel types. Six patients had recurrent bacteremia with two to four bacteremic episodes, five had chronic lymphatic disorders, and two had emm type stG840.0 in every episode. Recurrent bacteremia has not been described for invasive group A Streptococcus. We describe an entity of recurrent GGS bacteremia, which is associated with lymphatic disorders and possibly with emm stG840.0.