RESUMEN
We associated Laguna Negra virus with hantavirus pulmonary syndrome in Mato Grosso State, Brazil, and a previously unidentified potential host, the Calomys callidus rodent. Genetic testing revealed homologous sequencing in specimens from 20 humans and 8 mice. Further epidemiologic studies may lead to control of HPS in Mato Grosso State.
Asunto(s)
Síndrome Pulmonar por Hantavirus/veterinaria , Orthohantavirus/genética , Enfermedades de los Roedores/virología , Animales , Arvicolinae , Teorema de Bayes , Brasil/epidemiología , Variación Genética , Orthohantavirus/clasificación , Síndrome Pulmonar por Hantavirus/epidemiología , Síndrome Pulmonar por Hantavirus/virología , Humanos , Funciones de Verosimilitud , Ratones , Tipificación de Secuencias Multilocus , Proteínas de la Nucleocápside/genética , Filogenia , Enfermedades de los Roedores/epidemiologíaRESUMEN
To study the dynamics of wild rodent populations and identify potential hosts for hantavirus, we conducted an eco-epidemiologic study in Campo Novo do Parecis, Mato Grosso State, Brazil. We detected and genetically characterized Castelo dos Sonhos virus found in a species of pygmy rice rat (Oligoryzomys utiaritensis).
Asunto(s)
Reservorios de Enfermedades/veterinaria , Infecciones por Hantavirus/veterinaria , Orthohantavirus/genética , Enfermedades de los Roedores/epidemiología , Sigmodontinae/virología , Animales , Anticuerpos Antivirales/sangre , Brasil/epidemiología , ADN Viral/análisis , Reservorios de Enfermedades/virología , Orthohantavirus/inmunología , Orthohantavirus/aislamiento & purificación , Infecciones por Hantavirus/epidemiología , Infecciones por Hantavirus/virología , Filogenia , Enfermedades de los Roedores/virología , Análisis de Secuencia de ADNRESUMEN
The purpose of this study was to investigate the phylogenetic relationship of the Juquitiba virus (JUQV) carried by Oligoryzomys nigripes in endemic and non-endemic areas of Brazil. Wild rodents infected with the Juquitiba virus (JUQV) were sampled from a non-Hantavirus Cardiopulmonary Syndrome endemic area in Brazil. Three strains from O. nigripes were identified by the sequencing of the complete S segment and compared to previous studies of JUQV available in GenBank. The phylogenetic analysis of the complete S segment revealed two distinct clades; the first clade was composed of the JUQV from two non-endemic areas in Brazil and the second clade contained JUQV strains from Argentina, Paraguay and other Brazilian endemic areas.