RESUMEN
OBJECTIVES: To determine the long-term oncological outcome of organ-confined (Asunto(s)
Cuidados Posteriores/normas
, Carcinoma de Células Renales/cirugía
, Neoplasias Renales/cirugía
, Recurrencia Local de Neoplasia/epidemiología
, Nefrectomía
, Anciano
, Anciano de 80 o más Años
, Neoplasias Óseas/epidemiología
, Neoplasias Óseas/secundario
, Carcinoma de Células Renales/epidemiología
, Carcinoma de Células Renales/secundario
, Progresión de la Enfermedad
, Femenino
, Estudios de Seguimiento
, Humanos
, Incidencia
, Estimación de Kaplan-Meier
, Neoplasias Renales/mortalidad
, Neoplasias Renales/patología
, Esperanza de Vida
, Neoplasias Pulmonares/epidemiología
, Neoplasias Pulmonares/secundario
, Masculino
, Persona de Mediana Edad
, Recurrencia Local de Neoplasia/patología
, Estadificación de Neoplasias
, Guías de Práctica Clínica como Asunto
, Estudios Retrospectivos
, Factores de Tiempo
RESUMEN
INTRODUCTION: The study aimed to compare the incidence of cardiovascular events (CVEs) after donor nephrectomy (DN) and radical tumor nephrectomy (RN), according to an estimated glomerular filtration rate (eGFR), were evaluated over time. MATERIALS AND METHODS: Follow-up was collected for DN who underwent surgery from 1998 to 2007 for CVE and renal function. All DN were matched for age to patients treated by RN or adenoma enucleation (control group), who were eligible for DN. eGFR was estimated using the Cockgroft-Gould formula. Patients with preoperative comorbidities were excluded. RESULTS: Thirty DN (median age 48.9 years) were included with a median follow-up of 138.5 months (interquartile range 119-159). No significant differences in patients' characteristics were found preoperatively (p > 0.5). Four out of 30 DN developed a CVE (3 myocardial infarctions (MI), 1 stroke), 2 of 30 patients in the control group (both MI) and 8 of 30 RN patients (6 MI, 2 strokes, p > 0.05). Arterial hypertension developed in 14 DN (46.7%), in 12 (40%) after RN and in 15 controls. The CVE occurred after a median time of 68 months (5-231) and were related to a drop of â¼30% in the eGFR irrespective of the group. CONCLUSION: Decline of renal function after nephrectomy is the main risk factor for CVE. Close monitoring of renal function and new onset hypertension is warranted.