A Dual-Mode Optical Thermometer with High Sensitivity Based on BaAl12O19:Sm2+/SrAl12O19:Sm3+ Solid Solution Phosphors.

A series of BaAl12O19:Sm2+/SrAl12O19:Sm3+ mixed-phase phosphors were produced in one step using the traditional high-temperature solid-phase process. Because Sm is divalent in BaAl12O19 and trivalent in SrAl12O19, the coexistence of Sm2+ and Sm3+ is realized in the mixed-phase host. Since the temperature sensitivity of Sm2+ and Sm3+ in the solid solution host is significantly different, this makes it possible for the sample to measure temperature based on the fluorescence intensity ratio (FIR). The crystal model, ion emission spectrum, and temperature sensitivity of these phosphors are studied in detail. Under the co-excitation of a 410 nm excitation source, this sample has excellent temperature measurement performance in the range of 313-513 K. Based on the FIR method, the maximum absolute temperature sensitivity (Sa) is 0.55 K-1 at 513 K, and the maximum relative temperature sensitivity (Sr) is 2.47%K-1 at 453 K. Moreover, based on the photoluminescence lifetime temperature measurement mode, the largest value of Sa at 413 K is 0.046 K-1, and the maximum value of Sr at 473 K is 3.10%K-1. In short, the BaAl12O19:Sm2+/SrAl12O19:Sm3+ solid solution is a kind of phosphor with nice temperature measurement ability, and it has very strong potential in the application of noncontact optical thermometers.

Highly sensitive biosensor based on an all-dielectric asymmetric ring metasurface.

We propose an all-dielectric asymmetric ring-cylindrical metasurface. Based on the analysis of transmission characteristics and the calculation of electromagnetic field distribution of the metasurface with this element structure, it is found that the high Q resonance of the ultra-narrowband can be realized when the symmetry of the ring-cylindrical structure is broken. Meanwhile, it is found that the degree of asymmetry of the ring, the refractive index of the material, the radius of the ring, and the substrate have great influence on the Q value and resonant frequency of the metasurface. Our proposed metasurface structure is applied to the detection of biological molecules based on the change in refractive index of biomolecular solutions. The designed metasurface with high sensitivity to detect biomolecules with different refractive indices, the Q value can reach 365.03, and the sensitivity is increased by 90.36 GHz/RIU compared to that without substrate, while the figure of merit value is as high as 100.56, providing label-free detection of biomolecules.

Transmission terahertz power beam splitter based on a single-layer metal metasurface.

A periodic metasurface composed of a single layer of copper structure is proposed. The general transmission power beam splitter is composed of a multilayer structure, which is difficult to fabricate. The proposed single-layer terahertz wave power beam splitter contains only a single-layer circular hole cell structure, and it can control the transmission angle by controlling the arrangement mode of the coding cells. At the same time, we can control the transmission angle and the transmitted energy distribution of each beam based on different incident angles. A simple monolayer round-hole metasurface was prepared and its transmission characteristics were analyzed based on a terahertz time domain spectrometer. Compared with traditional splitter devices, our coding metasurface beam splitters with a single layer have the potential to promote the development of integrated optical systems.

Broadband stealth devices based on encoded metamaterials.

Based on the generalized Snell's law, the relationship between the phase gradient of the metasurface and the incident frequency is demonstrated, and the principle of the achromatic metasurface is developed. By adjusting the phase gradient and linear dispersion simultaneously, the function of achromatic aberration is realized, and the influence of chromatic aberration on the metasurface is reduced. We propose a metasurface stealth device with achromatic multilayer frame metasurfaces with beam deflection, steering, and collection functions so that the incident electromagnetic beam is transmitted around the stealth object without scattering. In the range of 0.45-0.9 THz, the stealth function can be achieved. We have shown that the achromatic principle, design method, and stealth structure provide a guide for achieving transmissive cloaking.

Transmission and reflection cloaking by using a zero-refractive-index photonic crystal in the microwave region.

We propose a rectangular column two-dimensional square lattice photonic crystal to realize zero refractive index. Through analysis of the energy band structure of the photonic crystal structure, the lattice constant and side length of the rectangular columns can be optimized, and the Dirac cone dispersion appears at the center of the Brillouin zone. The Dirac cone is formed by the interaction of a monopolar eigenstate and a dipolar eigenstate to form a triple accidental degenerate state. The effective medium theory is used to invert the effective electromagnetic parameters of the photonic crystal with a double zero refractive index. The zero-phase change and the focusing characteristic of the concave lens of this kind of zero-refractive-index material are verified. Importantly, we have achieved transmission and reflection cloaking with this zero-index medium. Through the analysis of the amplitude and phase distribution characteristics of the electromagnetic field, it is proved that the designed cloaking devices have obvious cloaking effect.

High-efficiency transmissive invisibility cloaking based on all-dielectric multilayer frame structure metasurfaces.

Metasurfaces provide a completely new path to realize the cloaking effect due to their excellent electromagnetic wavefront manipulation. However, most previous metasurfaces realized cloaking by using phase compensation, which is limited by the reflection phase formula and can be used only for reflection mode. We use the generalized Snell's law to propose a free-space transmission stealth device, consisting of multilayer all-dielectric metasurfaces. We utilize three phase gradient all-dielectric silicon metasurfaces that, respectively, play the role of beam splitting, steering, and collection to guide incident waves around the object, thereby forming an ideal stealth area in free space. All-dielectric metasurfaces can greatly reduce transmission loss and enhance efficiency to a large extent. The advantage of choosing an all-dielectric material is that it is easy to process and more suitable in practice. Simulation results of the near field and far field prove that this cloak has a cloaking effect at 1 THz. Our work opens up a new path for transmissive stealth.

Manipulation of the arbitrary scattering angle based on all-dielectric transmissive Pancharatnam Berry phase coding metasurfaces in the visible range.

In order to improve the transmitted efficiency of the metasurface in the visible range, an all-dielectric Pancharatnam-Berry phase unit structure was proposed. Using these Pancharatnam-Berry phase element particles with different rotation angles, all-dielectric encoding metasurfaces can be constructed. The encoding metasurface connects the physical coding particles with digital coding in digital signal processing. The manipulation of the continuous transmission angle requires the continuous change of the encoding metasurface period. Since the size of encoding particles on the coded metasurfaces cannot be designed to be infinitesimally small, it is impossible to obtain the continuously changing period of the coded metasurfaces. To manipulate effectively and freely the angle of scattering in the visible range, Fourier convolution principle in digital signal processing was introduced on all-dielectric encoding metasurfaces with Pancharatnam-Berry phase meta-atoms. The addition and subtraction operations on two initial encoding sequences can be implemented to obtain a new encoding sequence. The manipulation of the arbitrary scattering pattern after Fourier convolution operations on different encoding sequences can be realized, especially for larger abnormal deflection angles. The checkerboard encoding metasurface was also designed to further prove the applicability of the Fourier convolution principle. Moreover, by using the proposed all-dielectric highly efficient Pancharatnam-Berry phase encoding meta-atoms, these coded particles with different rotation angles can be precisely arranged to build the generators of the orbital angular momentum beam with different topological charges.

Design of two invisibility cloaks using transmissive and reflective metamaterial-based multilayer frame microstructures.

Ultrathin metamaterials provide new possibilities for the realization of cloaking devices because of their ability to control electromagnetic waves. However, applications of metamaterials in cloaking devices have been limited primarily to reflection-type carpet cloaks. Hence, a transmissive free-space cloak was developed using a multilayer frame structure, wherein highly transparent metamaterials were used to guide incident waves into propagating around an object. The cloaking effect was quantitatively verified using near-field and far-field distributions. Metamaterials allow for the cloaking shells of transmissive cloaks to be developed without spatially varying extreme parameters. Moreover, a transmissive invisible cloak with metamaterial-based mirrors was designed. The design principle of this cloak with a frame structure consists of four metamaterial-based mirrors and two metal mirrors. After covered with the designed metamaterials-based mirrors cloak, the outgoing electromagnetic wave is restored greatly as if the wave passes directly through the obstacle without distortion. This cloak used the metamaterials mirrors to adjust the reflected angle, so that the outgoing electromagnetic wave does not change direction, thereby achieving the cloaking effect.

Magnetic resonance-guided high-intensity focused ultrasound of uterine fibroids: whole-tumor quantitative perfusion for prediction of immediate ablation response.

BACKGROUND: In magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) treatment of uterine fibroids, the immediate ablation response is significantly affected by blood perfusion. The variability of measurement for blood perfusion is critical due to the inherent non-uniformity of tumor perfusion and its dependence on reproducible region of interest (ROI) placement. PURPOSE: To investigate the value of whole-tumor ROI (ROIwt) analysis for quantitative perfusion in predicting immediate ablation response of uterine fibroids in MR-HIFU. MATERIAL AND METHODS: Thirty-one fibroids in 28 eligible patients were treated with MR-HIFU. Quantitative perfusion parameters (Ktrans, Kep, and Vp) derived from dynamic contrast-enhanced MRI were obtained before MR-HIFU treatment. The ROIwt and single-layer ROI (ROIsl) were used for quantitative perfusion analysis. T1 contrast-enhanced MRI immediately after MR-HIFU treatment was conducted to determine the non-perfused volume ratio (NPVR). Intraclass correlation coefficient (ICC) was used for consistency test. Spearman's correlation and multivariate linear regression were used to investigate the predictors of the NPVR. Received operating characteristic (ROC) curve was used to test the predictive efficacy of quantitative perfusion parameter. RESULTS: The intra- and inter-observer ICC of the quantitative perfusion parameters from ROIwt were higher than those from ROIsl. Multivariate analysis showed that the Ktrans of ROIwt was a predictor of the immediate ablation response. ROC analysis displayed that the AUC of Ktrans of ROIwt is 0.817 in predicting the ablation response. CONCLUSION: Pretreatment Ktrans of ROIwt is more reliable and stable than that of ROIsl. It could be a predictor for the immediate ablation response of uterine fibroids in MR-HIFU.

Enhancement of bandwidth and angle response of metasurface cloaking through adding antireflective moth-eye-like microstructure.

Ultrathin metasurface provides a completely new path to realize cloaking devices on account of their fascinating ability to control electromagnetic wave. However, the conventional cloaking devices are limited by their narrow bandwidth. To overcome this challenge, we present the realization of ultrabroadband and wide angle metasurface cloaking through high refractive index dielectric layer and antireflective "moth-eye-like" microstructure in this work. Two options are proposed and demonstrated numerically in terahertz region. By using local phase compensation, the proposed carpet cloaks can suppress significantly the unexpected scattering and reconstruct wavefront. The cloaking effects of the proposed design are verified from 0.65THz to 0.9THz with a wide range of angles. Moreover, the proposed metasurface cloaking is probable to extend to the optical and microwave domains and can be applied in stealth, illusion optic, radar and antenna systems.

Flexible control of transmitting terahertz beams based on multilayer encoding metasurfaces.

The concept of encoding metasurfaces makes a connection between the physical metamaterial particles and the digital code so the digital coding can be performed on the coding surface for signal processing to achieve unusual physical phenomena. Here, a complete 2π transmission phase with high efficiency at the target frequency can be manipulated by a multilayer metasurface structure. Different period sequence codes are designed to obtain the deflection angles, and then a new sequence is obtained through a four-bit system operation sequence according to the Fourier convolution principle. This study shows that Fourier calculation provides an efficient way to optimize the coding to achieve a pre-designed transmitted beam. The advantage of this method over previous solutions in generating an anomalous single transmission beam is its flexibility and continuous control of arbitrary directions, and it is possible to transmit a normally incident terahertz beam to an abnormal arbitrary direction with cross-polarization. This work opens up a new digital perspective on the new approach to metamaterials, predicting the possibility of combining electromagnetic wave operations with the convolution theorems in digital signal processing and the transcoding surface.

[Preparation and Luminescent Properties of Blue Emitting Phosphor of Sr3 (PO4)2: Eu²âº for White LED].

A series of Sr3 (PO4)2: Eu²âº blue phosphors were synthesized by high temperature solid state method under N2-H2 reducing atmosphere. The crystal structures, excitation and emission spectra were characterized by X-ray diffraction (XRD) and Photoluminescence (PL), respectively. The results show that the Sr3 (PO4)2: Eu²âº phosphor can be efficiently excited by the wavelengths ranging from 310 to 390 nm, and the excitation peak wavelength locates at 359 nm. A wide emission spectrum (~150 nm, originating from the 4ƒ 5d¹-->4ƒ of the Eu²âº) with a peaking wavelength of 438 nm was obtained. Through the Gaussian fitting, we found that the emission band formed by two luminescence centers(430 and 459 nm), which indicated that the Eu²âº occupied two different Sr²âº sites in the substrate of Sr3(PO4)2. As the Eu²âº doping concentration is 7%, the maximum luminous intensity was obtained. With the increasing of the doping concentration of the Eu²âº, the concentration quenching effect occurred, and the emission peak wavelength has a red shift. The PL intensity of the Sr3 (PO4)2: Eu²âº phosphor is about 1.3 times than that of the blue emitting phosphor BaMgAl10O17: Eu²âº (BAM) which means that it is a promising candidate for the blue phosphor material for white LED.

Preoperative and postoperative MRI-based models versus clinical staging systems for predicting early recurrence in hepatocellular carcinoma.

BACKGROUND: To predict the early recurrence of HCC patients who received radical resection using preoperative variables based on Gd-EOB-DTPA enhanced MRI, followed by the comparison with the postoperative model and clinical staging systems. METHODS: One hundred and twenty-nine HCC patients who received radical resection were categorized into the early recurrence group (n = 48) and the early recurrence-free group (n = 81). Through COX regression analysis, statistically significant variables of laboratory, pathologic, and Gd-EOB-DTPA enhanced MRI results were identified. The preoperative and postoperative models were established to predict early recurrence, and the prognostic performances and differences were compared between the two models and clinical staging systems. RESULTS: Six variables were incorporated into the preoperative model, including alpha-fetoprotein (AFP) level, aspartate aminotransferase/platelet ratio index (APRI), rim arterial phase hyperenhancement (rim APHE), peritumoral hypointensity on hepatobiliary phase (HBP), CERHBP (tumor-to-liver SI ratio on hepatobiliary phase imaging), and ADC value. Moreover, the postoperative model was developed by adding microvascular invasion (MVI) and histological grade. The C-index of the preoperative model and postoperative model were 0.889 and 0.901 (p = 0.211) respectively. Using receiver operating characteristic curve analysis (ROC) and decision curve analysis (DCA), it was determined that the innovative models we developed had superior predictive capabilities for early recurrence in comparison to current clinical staging systems. HCC patients who received radical resection were stratified into low-, medium-, and high-risk groups on the basis of the preoperative and postoperative models. CONCLUSION: The preoperative and postoperative MRI-based models built in this study were more competent compared with clinical staging systems to predict the early recurrence in hepatocellular carcinoma.

Multiband superconductivity of heavy electrons in a TlNi2Se2 single crystal.

We have made the first observation of superconductivity in TlNi2Se2 at T(C)=3.7 K, and it appears to involve heavy electrons with an effective mass m*=(14-20)m(b), as inferred from the normal-state electronic specific heat and the upper critical field, H(C2)(T). We found that the zero-field electronic specific-heat data, C(es)(T) (0.5 K≤T<3.7 K) in the superconducting state can be fitted with a two-gap BCS model, indicating that TlNi2Se2 seems to be a multiband superconductor, which is consistent with the band calculation for the isostructural KNi2S2. It is also found that the electronic specific-heat coefficient in the mixed state γN(H) exhibits a H(1/2) behavior, which is considered as a common feature of the d-wave superconductors. TlNi2Se2, as a d-electron system with heavy electron superconductivity, may be a bridge between cuprate- or iron-based and conventional heavy-fermion superconductors.

EADC Values in Diagnosis of Renal Lesions by 3.0 T Diffusion-Weighted Magnetic Resonance Imaging: Compared with the ADC Values.

Exponential apparent diffusion coefficient (EADC) is an indicator of diffusion-weighted imaging (DWI) and reflects the pathological changes of tissues quantitatively. However, no study has been investigated in the space-occupying kidney disease using EADC values. This study aims to evaluate the diagnostic role of EADC values at a high magnetic field strength (3.0 T) in kidney neoplastic lesions, compared with that of the ADC values. Ninety patients with suspected renal tumors (including 101 suspected renal lesions) and 20 healthy volunteers were performed MRI scanning. Diffusion-weighted imaging was performed with a single-shot spin-echo echo-planar imaging (SE-EPI) sequence at a diffusion gradient of b = 500 s/mm2. We found renal cell carcinoma (RCC) can be distinguished from angiomyolipoma, and clear cell carcinoma can be distinguished from non-clear cell carcinoma by EADC value. There was significant difference in overall EADC values between renal cell carcinoma (0.150 ± 0.059) and angiomyolipoma (0.270 ± 0.108) when b value was 500 s/mm2. When receiver operating characteristic (ROC) was higher than 0.192, the sensitivity and specificity of EADC value of renal cell carcinoma were 84.6 and 81.1 %, respectively. In conclusion, EADC map shows the internal structure of the kidney tumor more intuitively than the ADC map dose, and is also in line with the observation habits of the clinicians. EADC can be used as an effective imaging method for tumor diagnosis.

Rapid ultra-sensitive nucleic acid detection using plasmonic fiber-optic spectral combs and gold nanoparticle-tagged targets.

Nucleic acid (NA) is a widely-used biomarker for viruses. Accurate quantification of NA can provide a reliable basis for point-of-care diagnosis and treatment. Here, we propose a tilted fiber Bragg grating (TFBG)-based plasmonic fiber-optic spectral comb for fast response and ultralow limit NA detection. The TFBG is coated with a gold film which enables excitation of surface plasmon resonance (SPR), and single-stranded probe NAs with known base sequences are assembled on the gold film. To enhance sensitivity of refractive index (RI) for sensing a chosen combination of probe and target NAs around the TFBG surface, gold nanoparticles (AuNPs) are bonded to the target NA molecules as "RI-labels". The NA combination-induced aggregation of AuNPs induces significant spectral responses in the TFBG that would be below the detection threshold for the NAs in the absence of the AuNPs. The proposed TFBG-SPR NA sensor shows a fast response time of 30 s and an ultra-wide NA detection range from 1 × 10-18 mol/L to 1 × 10-7 mol/L. In the NA concentration range of 1 × 10-12 mol/L (1 pM) to 105 pM, an ultra-high sensitivity of 1.534 dB/lg(pM) is obtained. The sensor achieves an ultra-low limit of detection down to 1.0 × 10-18 mol/L (1 aM), which is more than an order of magnitude lower than the previous reports. The proposed sensor not only shows potentials in practical applications of NA detection, but also provides a new way for TFBG-SPR biochemical sensors to achieve higher RI sensitivity.

Multi-Function Reflective Vector Light Fields Generated by All-Dielectric Encoding Metasurface.

Traditional optics usually studies the uniform polarization state of light. Compared with uniform vector beams, non-uniform vector beams have more polarization information. Most of the research on generating cylindrical vector beams using metasurfaces focuses on generating transmitted beams using the geometric phase. However, the geometric phase requires the incident light to be circularly polarized, which limits the design freedom. Here, an all-dielectric reflective metasurface is designed to generate different output light according to the different polarization states of the incident light. By combining the two encoding arrangements of the dynamic phase and the geometric phase, the output light is a radial vector beam when the linearly polarized light is incident along the x-direction. Under the incidence of linearly polarized light along the y-direction, the generated output light is an azimuthal vector beam. Under the incidence of left-handed circularly polarized light, the generated output light is a vortex beam with a topological charge of -1. Under the incidence of right-handed circularly polarized light, the generated output light is a vortex beam with a topological charge of +1. The proposed reflective metasurface has potential applications in generating vector beams with high integration.

CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression.

Osteoporosis (OP) is one of the most common bone diseases, especially in women after menopause. Increasing evidence shows that non-coding RNAs are implicated in the pathogenesis of OP. In this study, based on the published circular RNA profiling data between OP patients and healthy controls, we found that circRNA_0001795 (circ_0001795) is downregulated in OP samples, which was further validated in the OP samples collected in this study. We therefore investigated the functional role and molecular mechanism of circ_0001795 in the osteogenic differentiation of human bone marrow stromal cells (hBMSCs) hBMSCs by alkaline phosphatase (ALP) activity assay, ALP and Alizarin Red S (ALS) Staining, luciferase reporter assay. Our data revealed that the overexpression of circ_0001795 could significantly promote the osteogenic differentiation of hBMSCs. MiRNA-339-5p (miR-339-5p) was identified as a target of circ_0001795, and miR-339-5p mimic attenuated the effect of circ_0001795 overexpression. MiR-339-5p downregulated yes-associated protein 1 (YAP1), which mediates the effect of circ_0001795 overexpression. Overall, this study uncovered the role of circ_0001795/miR-339-5p/YAP1 axis in regulating osteogenic differentiation, indicating that targeting Circ_0001795 could serve as a novel therapeutic target for OP.

Multiparametric MRI combined with liver volume for quantitative evaluation of liver function in patients with cirrhosis.

PURPOSE We aimed to establish a liver function evaluation model by combining multiparametric magnetic resonance imaging (MRI) with liver volume (LV) and further verify the effectiveness of the model to evaluate liver function. METHODS This retrospective study included 101 consecutive cirrhosis patients (69 cases for modeling group and 32 cases for validation group) who underwent gadoxetic acid-enhanced MRI. Five signal intensity parameters were obtained by measuring the signal intensities of the liver, spleen, and erector spinae before and 20 minutes after gadoxetic acid disodium enhancement. The dif fusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) were obtained from intravoxel incoherent motion diffusion-weighted imaging. The LV parameters (Vliver, Vspleen, and Vliver/Vspleen) were obtained using 3-dimensional image generation software. The most effec tive parameter was selected from each of the 3 methods, and a multivariate regression model for liver function evaluation was established and validated. RESULTS In the modeling group, relative enhancement (RE), D*, and Vliver/Vspleen showed significant dif ferences among the different liver function groups (P < .001). Receiver operating characteristic analysis showed that these parameters had the highest area under the curve (AUC) values for dis tinguishing Child-Pugh A from Child-Pugh B and C groups (0.917, 0.929, and 0.885, respectively). The following liver function model was obtained by multivariate regression analysis: F(x)=3.96 - 1.243 (RE) - 0.034 (D*) - 0.080 (Vliver/Vspleen) (R2=0.811, P < .001). In the patients with cirrhosis, the F(x) of Child-Pugh A, B, and C were 1.16 ± 0.44, 1.95 ± 0.29, and 2.79 ± 0.38, respectively. In the validation group, the AUC for F(x) to distinguish Child-Pugh A from Child-Pugh B and C was 0.973. CONCLUSION Combining multiparametric MRI with LV effectively distinguished patients with different Child Pugh grades. This model could hence be useful as a novel radiological marker to estimate the liver function.

Methylcobalamin Alleviates Neuronal Apoptosis and Cognitive Decline Induced by PM2.5 Exposure in Mice.

BACKGROUND: Fine particulate matter (particulate matter 2.5, PM2.5) is considered one of the harmful factors to neuronal functions. Apoptosis is one of the mechanisms of neuronal injury induced by PM2.5. Methylcobalamine (MeCbl) has been shown to have anti-apoptotic and neuroprotective effects. OBJECTIVE: The current work tried to explore the neuroprotective effects and mechanisms that MeCbl protects mice against cognitive impairment and neuronal apoptosis induced by chronic real-time PM2.5 exposure. METHODS: Twenty-four 6-week-old male C57BL/6 mice were exposed to ambient PM2.5 and fed with MeCbl for 6 months. Morris water maze was used to evaluate the changes of spatial learning and memory ability in mice. PC12 cells and primary hippocampal neurons were applied as the in vitro model. Cell viability, cellular reactive oxygen species (ROS) and the expressions of apoptosis-related proteins were examined. And cells were stained with JC-1 and mitochondrial membrane potential was evaluated. RESULTS: In C57BL/6 mice, MeCbl supplementation alleviated cognitive impairment and apoptosis-related protein expression induced by PM2.5 exposure. In in vitro cell model, MeCbl supplementation could effectively rescue the downregulation of cell viability induced by PM2.5, and inhibited the increased levels of ROS, cellular apoptosis, and the expressions of apoptosis related proteins related to PM2.5 treatment, which may be associated with modulation of mitochondrial function. CONCLUSION: MeCbl treatment alleviated cognitive impairment and neuronal apoptosis induced by PM2.5 both in vivo and in vitro. The mechanism for the neuroprotective effects of MeCbl may at least be partially dependent on the regulation of mitochondrial apoptosis.