Pegcetacoplan Treatment and Consensus Features of Geographic Atrophy Over 24 Months.

Importance: Despite widespread availability and consensus on its advantages for detailed imaging of geographic atrophy (GA), spectral-domain optical coherence tomography (SD-OCT) might benefit from automated quantitative OCT analyses in GA diagnosis, monitoring, and reporting of its landmark clinical trials. Objective: To analyze the association between pegcetacoplan and consensus GA SD-OCT end points. Design, Setting, and Participants: This was a post hoc analysis of 11 614 SD-OCT volumes from 936 of the 1258 participants in 2 parallel phase 3 studies, the Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OAKS) and Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (DERBY). OAKS and DERBY were 24-month, multicenter, randomized, double-masked, sham-controlled studies conducted from August 2018 to July 2020 among adults with GA with total area 2.5 to 17.5 mm2 on fundus autofluorescence imaging (if multifocal, at least 1 lesion ≥1.25 mm2). This analysis was conducted from September to December 2023. Interventions: Study participants received pegcetacoplan, 15 mg per 0.1-mL intravitreal injection, monthly or every other month, or sham injection monthly or every other month. Main Outcomes and Measures: The primary end point was the least squares mean change from baseline in area of retinal pigment epithelium and outer retinal atrophy in each of the 3 treatment arms (pegcetacoplan monthly, pegcetacoplan every other month, and pooled sham [sham monthly and sham every other month]) at 24 months. Feature-specific area analysis was conducted by Early Treatment Diabetic Retinopathy Study (ETDRS) regions of interest (ie, foveal, parafoveal, and perifoveal). Results: Among 936 participants, the mean (SD) age was 78.5 (7.22) years, and 570 participants (60.9%) were female. Pegcetacoplan, but not sham treatment, was associated with reduced growth rates of SD-OCT biomarkers for GA for up to 24 months. Reductions vs sham in least squares mean (SE) change from baseline of retinal pigment epithelium and outer retinal atrophy area were detectable at every time point from 3 through 24 months (least squares mean difference vs pooled sham at month 24, pegcetacoplan monthly: -0.86 mm2; 95% CI, -1.15 to -0.57; P < .001; pegcetacoplan every other month: -0.69 mm2; 95% CI, -0.98 to -0.39; P < .001). This association was more pronounced with more frequent dosing (pegcetacoplan monthly vs pegcetacoplan every other month at month 24: -0.17 mm2; 95% CI, -0.43 to 0.08; P = .17). Stronger associations were observed in the parafoveal and perifoveal regions for both pegcetacoplan monthly and pegcetacoplan every other month. Conclusions and Relevance: These findings offer additional insight into the potential effects of pegcetacoplan on the development of GA, including potential effects on the retinal pigment epithelium and photoreceptors. Trial Registration: ClinicalTrials.gov Identifiers: NCT03525600 and NCT03525613.

Effect of Systemic and Auricular Acupuncture with a 2/100 Hz Frequency and Nogier Frequency in Fibromyalgia: a Randomized Clinical Trial, Pilot Study.

Background: Fibromyalgia is a syndrome of chronic, generalized muscular pain, accompanied by sleep disturbances, fatigue and cardic autonomic dysfunction that will affect the quality of life. There is currently no gold standard treatment. There are limitations of studies with electroacupuncture in auricular acupuncture. Objectives: We evaluate the effects of systemic electroacupuncture (EA) with frequencies of 2/100 Hz associated of auricular acupuncture with a Nogier frequency (2.28, 4.56 and 9.12 Hz) for pain intensity, heart rate variability (HRV), and quality of life in fibromyalgia. Methods: Randomized clinical trial, a pilot study. Eighteen volunteers were randomized into a control group (CG, n = 9) and an experimental group (EG, n = 9). Six systemic EA sessions systemic and auricular were applied in the EG for 20 min, twice a week, for six weeks consecutive. The Numerical Pain Assessment Scale (NPRS), 2010 diagnostic criteria of the American College of Rheumatology (FDC 2010), Fibromyalgia Impact Questionnaire (FIQ) and analysis of HRV were the instruments used. The independent t-test compared to the groups was applied. Results: There was no statistically significant difference for the primary outcome for NPRS (p > 0.05). In the secondary outcome there was a significant difference in the total score and in some FIQ domains (p = 0.008) and some variables such as pain (p = 0.02) and anxiety (p = 0.006). There was no significant difference for the FDC 2010 and HRV variables (p > 0.05). Conclusion: 2/100 Hz systemic EA associated with the Nogier frequency positively influenced some quality of life variables; however, pain intensity, diagnostic criteria, and HRV variables did not change.

Molecular phylogeny of Aphyocharacinae (Characiformes, Characidae) with morphological diagnoses for the subfamily and recognized genera.

The subfamily Aphyocharacinae was recently redefined to comprise eight genera: Aphyocharax, Prionobrama, Paragoniates, Phenagoniates, Leptagoniates, Xenagoniates, Rachoviscus and Inpaichthys. This new composition, however, is partially incongruent with published results of molecular studies especially concerning the positions of Rachoviscus and Inpaichthys. Our goal was to investigate the monophyly of Aphyocharacinae and its interrelationships using three distinct phylogenetic methodologies: Maximum-likelihood and Bayesian analyses of molecular data, and also Parsimony analysis of a concatenated molecular and morphological dataset. All tree topologies recovered herein suggest that Rachoviscus, Inpaichthys and Leptagoniates pi do not belong to the Aphyocharacinae. The remaining aphyocharacin taxa analyzed do form a monophyletic group, which is itself composed of two subgroups being one comprised of Paragoniates, Phenagoniates, Leptagoniates and Xenagoniates, and the other comprised of Aphyocharax and Prionobrama. Internal relationships among these genera are statistically well supported and morphological synapomorphies are presented at the generic level. All tree topologies also indicate that Aphyocharacidium is closely related to Aphyocharacinae suggesting that it should be included in this subfamily. As recognized in the present study, the Aphyocharacinae is diagnosed by a single morphological synapomorphy: two dorsal-fin rays articulating with the first dorsal pterygiophore.

Pulsed Laser Acupuncture in the Treatment of Pain and Heart Rate Variability in Fibromyalgia Patients: A Pilot Randomized Clinical Trial.

Introduction: Laser acupuncture (LA) is a medically approved treatment for chronic pain, especially fibromyalgia. It is widely known that all pain is related to autonomic modulation, which may influence heart rate variability (HRV). There are robust studies in the literature on the effect of LA with continuous frequency on musculoskeletal pain and autonomic modulation. However, little is known about the effect of pulsed frequency on fibromyalgia. Therefore, this study aimed to evaluate whether an individualized intervention protocol applying pulsed LA would provide benefits related to pain symptoms and cardiac autonomic modulation in patients with fibromyalgia. Methods: In this pilot randomized clinical controlled trial, the sample consisted of women with fibromyalgia between the ages of 40 and 80, randomized into two groups: a control group (CG; n=10) and an experimental group (EG; n=10). EG received the intervention twice per week for 3 weeks. Statistical analysis was conducted by delta (difference between post-intervention and pre-intervention) and the Shapiro-Wilk test (normality). For comparison between the groups, the Mann-Whitney test was used. Results: The results showed a significant reduction in pain intensity as reported via the pain numerical scale (PNS; P=0.00), generalized pain index (GPI; P=0.00), and symptom severity scale (SSS; P=0.00). There was no significant difference in any HRV variable (P>0.05). Conclusion: Pulsed LA, when applied in an individualized protocol, can reduce pain intensity, as reported on the PNS, GPI, and SSS. However, no therapeutic effect was observed for HRV.

How Has Electromyography Been Used to Assess Reaching in Infants? A Systematic Review.

The aims of this systematic review were: to investigate the use of surface electromyography in the assessment of reaching in infants; to assess the usefulness of this tool to the assessment of reaching, and its parameters and limitations; to assess the methodological quality of the studies available in the literature. The search in the databases MEDLINE, SciELO, LILACS, Embase, PEDro, Cochrane, and EBSCO resulted in 5 selected studies. The studies aimed to elucidate how muscle behavior occurs in the development of reaching. The lack of standardized recommendations for the use of EMG in infants limit the reproducibility and comparison between studies. There are challenges and limitations regarding the use of electromyography in infants, which are caused by peculiarities inherent to the development of the neuromotor and musculoskeletal systems.

Nursing care regarding the psycho-emotional aspects of women submitted to mastectomy

Breast cancer, or breast neoplasm, is one of the most frequent types of cancer, and one of the most prevalent among women. The diagnosis and specific treatments, such as mastectomy surgery, lead women to experience different feelings, with the most predominant negative thoughts. In this way, the objective of this study is to describe the importance of nursing care in the face of the psycho-emotional aspects of women after mastectomy. This is an integrative literature review study, developed in electronic Medline and Lilacs databases. The following terms were used: Breast neoplasm; Nursing; Emotions; Mastectomy. A total of 2,314 articles were found, of which eight were selected. The results and discussions were divided into two thematic axes: The first deals with the emotions of women after mastectomy, whose feelings arising from the diagnosis of the disease start to affect different areas, such as personality, sexuality, family, and social relationships. Furthermore, the second deals with nursing care after mastectomy, which must be conducted integrally, aiming at restoring physical and emotional health. Nursing is the vehicle capable of planning and collaborating with these women, promoting humanized treatment and assistance, oriented and aimed at a better quality of life, and stimulating self-help, self-esteem, and acceptance of their body.

A new desert-dwelling dinosaur (Theropoda, Noasaurinae) from the Cretaceous of south Brazil.

Noasaurines form an enigmatic group of small-bodied predatory theropod dinosaurs known from the Late Cretaceous of Gondwana. They are relatively rare, with notable records in Argentina and Madagascar, and possible remains reported for Brazil, India, and continental Africa. In south-central Brazil, the deposits of the Bauru Basin have yielded a rich tetrapod fauna, which is concentrated in the Bauru Group. The mainly aeolian deposits of the Caiuá Group, on the contrary, bear a scarce fossil record composed only of lizards, turtles, and pterosaurs. Here, we describe the first dinosaur of the Caiuá Group, which also represents the best-preserved theropod of the entire Bauru Basin known to date. The recovered skeletal parts (vertebrae, girdles, limbs, and scarce cranial elements) show that the new taxon was just over 1 m long, with a unique anatomy among theropods. The shafts of its metatarsals II and IV are very lateromedially compressed, as are the blade-like ungual phalanges of the respective digits. This implies that the new taxon could have been functionally monodactyl, with a main central weight-bearing digit, flanked by neighbouring elements positioned very close to digit III or even held free of the ground. Such anatomical adaptation is formerly unrecorded among archosaurs, but has been previously inferred from footprints of the same stratigraphic unit that yielded the new dinosaur. A phylogenetic analysis nests the new taxon within the Noasaurinae clade, which is unresolved because of the multiple alternative positions that Noasaurus leali can acquire in the optimal trees. The exclusion of the latter form results in positioning the new dinosaur as the sister-taxon of the Argentinean Velocisaurus unicus.

Obesidade nos registros de óbito de Síndrome Respiratória Aguda Grave por Covid-19, Brasil, 2021 / Obesity in Severe Acute Respiratory Syndrome death records by Covid-19, Brazil, 2021 / Obesidad en los registros de defunción del síndrome respiratorio agudo severo por Covid-19, Brasil, 2021

Segundo a Organização Mundial da Saúde (OMS), o sobrepeso e a obesidade podem ser definidas enquanto o acúmulo anormal ou excessivo de gordura, podendo se constituir enquanto prejudiais a saúde.1 Os referidos problemas de saúde pública tem adquirido proporções pandêmicas, onde aproximadamente, 4 milhões de pessoas morrem a cada ano em sua decorrência ou por conta de complicações relacionadas

Brevíssimas considerações históricas sobre o processo de vacinação de crianças e adolescentes contra a COVID-19 no Brasil / Very brief historical considerations about the process of vaccination of children and adolescents against COVID-19 in Brazil / Breves consideraciones históricas sobre el proceso de vacunación de niños y adolescentes contra la COVID-19 en Brasil

Segundo a Organização Mundial da Saúde (OMS), o sobrepeso e a obesidade podem ser definidas enquanto o acúmulo anormal ou excessivo de gordura, podendo se constituir enquanto prejudiais a saúde.1 Os referidos problemas de saúde pública tem adquirido proporções pandêmicas, onde aproximadamente, 4 milhões de pessoas morrem a cada ano em sua decorrência ou por conta de complicações relacionadas

Perfil sociodemográfico e sociopolítico dos profissionais de enfermagem candidatos nas eleições municipais de 2020 / Sociodemographic and socio-political profile of candidate nursing professionals in the 2020 municipal elections / Perfil sociodemográfico y sociopolítico de los profesionales de enfermería candidatos a las elecciones municipales de 2020

Objetivo: Analisar o perfil socioeconômico e sociopolítico de profissionais de enfermagem que se candidataram nas eleições municiais de 2020. Método: Estudo exploratório, descritivo, comparativo e quantitativo, sendo os dados adquiridos no Tribunal Superior Eleitoral (TSE). Resultados: Foram identificados 8.605 profissionais de enfermagem, sendo que 54,5% (n=4.688) formada por técnicos e auxiliares de enfermagem e 45,5% (n= 3.917) de enfermeiros, 70,7% (n=6.081) eram de pessoas do sexo feminino, 36,5% (n=3.140) possuíam entre 40 a 49 anos, 48% (n=4.128) eram de cor/raça branca, 45,4% (n=3.906) eram casadas(os), 49,4% (n=4.253) possuíam ensino médio completo (EMC), 99,5% (n=8.566) eram brasileiros natos, 95,6% (n=8.230) concorreram ao cargo de vereador, 97,1% (n=8.356) não estavam concorrendo à reeleição, 97,1% (n=8.356) concorrendo na forma de partido político isolado e 8,9% (n=764) se elegeram pelo Movimento Democrático Brasileiro (MDB). Considerações finais: Foi identificada reduzida participação de profissionais de enfermagem no pleito eleitoral desenvolvido no ano de 2020.

Objective: To analyze the socioeconomic and socio-political profile of nursing professionals who ran in the 2020 municipal elections. Method: Exploratory, descriptive, comparative and quantitative study, the data being acquired at the Superior Electoral Court (TSE). Results: 8.605 nursing professionals were identified, 54.5% (n=4.688) of nursing technicians and assistants and 45.5% (n=3.917) of nurses, 70.7% (n=6.081) were of female, 36.5% (n=3.140) were between 40 and 49 years old, 48% (n=4.128) were white 45.4% (n=3.906) were married, 49.4% (n=4.253) had completed high school (EMC), 99.5% (n=8.566) were born Brazilians, 95.6% (n=8.230) ran for the position of councilor, 97.1% (n=8.356) were not running for re-election, 97,1% (n=8.356) running as an isolated political party and 8.9% (n=764) were elected by the Brazilian Democratic Movement (MDB). Final considerations: A reduced participation of nursing professionals in the electoral election developed in 2020 was identified.

Objetivo: Analizar el perfil socioeconómico y sociopolítico de los profesionales de enfermería que se presentaron a las elecciones municipales de 2020. Método: Estudio exploratorio, descriptivo, comparativo y cuantitativo, siendo los datos adquiridos en el Tribunal Superior Electoral (TSE). Resultados: Se identificaron 8.605 profesionales de enfermería, 54.5% (n=4.688) de técnicos y auxiliares de enfermería y 45.5% (n=3.917) de enfermeras, 70.7% (n=6.081) fueron de las mujeres, el 36,5% (n=3.140) tenían entre 40 y 49 años, el 48% (n=4.128) eran blancas, 45,4% (n=3.906) estaban casadas, 49,4% (n=4.253) había completado la escuela secundaria (EMC), 99,5% (n=8.566) nacieron brasileños, 95,6% (n=8.230) se postuló para el cargo de concejal, 97,1% (n=8.356) no se postularon para la reelección, el 97,1% (n=8.356) se postuló como partido político aislado y el 8,9% (n=764) fueron elegidos por el Movimiento Democrático Brasileño (BMD). Consideraciones finales: Se identificó una reducida participación de los profesionales de enfermería en la elección electoral desarrollada en 2020.

Avaliação do acesso aos serviços da atenção primária na perspectiva dos enfermeiros / Evaluation of access to primary care services under nurses' perspective / Evaluación del acceso a los servicios de atención primaria desde la perspectiva de la enfermería

O acesso é considerado atributo essencial para Atenção Primária à Saúde (APS). Objetivos: caracterizar o perfil sociodemográfico e profissional dos enfermeiros de Unidades Básicas de Saúde (UBS) tradicionais e avaliar o acesso de primeiro contato dos usuários. Método: pesquisa de campo, transversal, descritiva, conduzida por entrevista e aplicação de questionário estruturado e instrumento PCATool, versão profissionais. Resultados: 100% (n= 08) eram do sexo feminino, idade média de 37,7 anos. 62,5% (n=05) atendem à demanda espontânea, com agendamentos subsequentes, 12,5% (n=01) atendem à demanda exclusivamente programada. 87,5% (n=07) não apontaram dificuldades no acesso dos usuários. Acolhimento e atendimento às demandas espontâneas com atendimentos no dia e/ou agendamentos são as principais ações dos enfermeiros nas UBS. Os enfermeiros avaliaram o acesso de primeiro contato insuficiente, com barreiras importantes. Conclusão: entraves no acesso de primeiro contato aos serviços da APS dificultam a organização dos atendimentos de demanda programada e espontânea (Au).

The access is considered an essential attribute to Primary Health Care (HPA). Objectives: to characterize the sociodemographic and professional profile of nurses in traditional Health Care Unities (HCU) and to evaluate the first contact access of users. Method: field research, transversal, descriptive, carried out by interview and application of a structured and instrumented PCATool survey, professional version. Results: 100% (n=08) were female, average age of 37,7 years old. 62,5% (n=05) attend spontaneous demand, with subsequent scheduling, 12,5% (n=01) attend exclusively programmed demand. 87,5% (n=07) do not point out difficulties in the users access. Reception and assistance of the spontaneous demands with daily service and/or scheduling are the main actions of nurses in the HCU. The nurses evaluated as insufficient the first contact access, with important barriers. Conclusion: obstacles in the first contact access to the HPA services hamper the organization of the services of spontaneous and programmed demand (Au).

El acceso se considera un atributo esencial de la Atención Primaria de la Salud (APS). Objetivos: caracterizar el perfil sociodemográfico y profesional de los enfermeros de las Unidades Básicas de Salud (UBS) tradicionales y evaluar el acceso al primer contacto de los usuarios. Método: investigación de campo, transversal, descriptiva, realizada mediante entrevista y aplicación de cuestionario estructurado e instrumento PCATool, versión profesional. Resultados: 100% (n = 08) era del sexo femenino, edad media 37,7 años. El 62,5% (n = 05) satisface la demanda espontánea, con programación posterior, el 12,5% (n = 01) satisface solamente la demanda programada. El 87,5% (n = 07) no indicó dificultades en el acceso de los usuarios. Las principales acciones de los enfermeros en la UBS son recibir a los usuarios y satisfacer las demandas espontáneas con atención durante el día y/o programación. Los enfermeros evaluaron el acceso al primer contacto como insuficiente, con barreras importantes. Conclusión: las barreras para el acceso al primer contacto a los servicios de la APS obstaculizan la organización de la atención de la demanda programada y espontánea (Au).

Comorbidades e fatores de risco identificados em pessoas que vieram a óbito por Síndrome Respiratória Aguda Grave por Covid-19 / Comorbidities and risk factors identified in people who died from Severe Acute Respiratory Syndrome caused by Covid-19 / Comorbilidades y factores de riesgo identificados en personas que fallecieron por síndrome respiratorio agudo severo por Covid-19

Objetivo: Analisar a frequência de registros de casos de comorbidades e fatores de riscos relacionados aos óbitos de Síndrome Respiratória Aguda Grave (SRAG) por Covid-19 até a Semana Epidemiológica (SE) 40, no recorte geográfico formado pelo "Brasil", no recorte histórico formado pelo ano de "2021". Método: Estudo exploratório, descritivo e de abordagem quantitativa. Os dados foram adquiridos junto ao Sistema de Informação da Vigilância Epidemiológica da Gripe (SIVEP-Gripe) do Ministério da Saúde (MS). Resultados: Foi identificado o universo de 386.094 registros, com média e desvio-padrão de (35.099,5±49.151,4). Dentre as comorbidades e fatores de riscos identificados, as cardiopatias contabilizaram a maior preponderância com 39,2% (n=151.358) e a Síndrome de Down (SD) a menor com 0,4% (n=1.384). Conclusão: Foi possível identificar a relação existente entre as várias comorbidades e fatores de risco identificados, no que se refere a SRAG por COVID-19 no recorte geográfico e histórico analisados.

Objective: To analyze the frequency of records of cases of comorbidities and risk factors related to deaths from Severe Acute Respiratory Syndrome (SRAG) by Covid-19 until the Epidemiological Week (SE) 40, in the geographic cut formed by "Brazil", in the clipping history formed by the year "2021". Method: Exploratory, descriptive and quantitative approach study. Data were acquired from the Influenza Epidemiological Surveillance Information System (SIVEP-Influenza) of the Ministry of Health (MS). Results: The universe of 386,094 records was identified, with a mean and standard deviation of (35099.5±49151.4). Among the comorbidities and risk factors identified, heart disease accounted for the greatest preponderance with 39.2% (n=151,358) and Down Syndrome (DS) the smallest with 0.4% (n=1,384). Conclusion: It was possible to identify the existing relationship between the various comorbidities and risk factors identified, with regard to SRAG by COVID-19 in the geographic and historical context analyzed.

Objetivo: Analizar la frecuencia de registros de casos de comorbilidades y factores de riesgo relacionados con muertes por Síndrome Respiratorio Agudo Severo (SRAG) por Covid-19 hasta la Semana Epidemiológica (SE) 40, en el corte geográfico formado por "Brasil", en el historial de recortes formado por el año "2021". Método: Estudio exploratorio, descriptivo y de abordaje cuantitativo. Los datos se obtuvieron del Sistema de Información de Vigilancia Epidemiológica de Influenza (SIVEP-Influenza) del Ministerio de Salud (MS). Resultados: Se identificó el universo de 386,094 registros, con una media y desviación estándar de (35099.5±49151.4). Entre las comorbilidades y factores de riesgo identificados, la cardiopatía representó la mayor preponderancia con el 39,2% (n=151.358) y el Síndrome de Down (SD) el menor con el 0,4% (n=1.384). Conclusión: Se pudo identificar la relación existente entre las distintas comorbilidades y factores de riesgo identificados, respecto al SRAG por COVID-19 en el contexto geográfico e histórico analizado.

Variantes de atenção e/ou preocupação por sequenciamento genômico do COVID-19 no Brasil / Attention and/or concern variants for COVID-19 genomic sequencing in Brazil / Variantes de atención y / o preocupación para la secuenciación genómica de COVID-19 no Brasil

Na cidade de Wuhan, província de Hubei na República Popular da China, foi registrado pelas autoridades locais, um evento classificado enquanto surto, que permitiu a realização do diagnosticado de pneumonia (PNM).1,2 Este importante fenômeno foi datado no mês de dezembro do ano de 2019, sendo identificada uma cepa de coronavírus desconhecida até aquele momento, e que se espalhou rapidamente, apresentando o seu elevado potencial de transmissibilidade em vinte e quatro (24) outros países...

Ocorrências policiais de assédio sexual em Brasília, Distrito Federal e regiões administrativas, 2010 a 2020 / Police occurrences of sexual harassment in Brasília, Federal District and administrative regions, 2010 to 2020 / Incidentes policiales de acoso sexual en Brasília, Distrito Federal y regiones administrativas, 2010 a 2020

Objetivo: Analisar a frequência de ocorrências policiais relacionadas a assédio sexual, em Brasília, Distrito Federal (DF) e regiões administrativas entre 2010 a 2020. Método: Estudo epidemiológico, exploratório, descritivo e quantitativo. Os dados foram adquiridos junto a Polícia Civil do Distrito Federal (PCDF). Resultados: Foram identificados 528 registros com média e desvio-padrão (48±23,9). O ano de 2019 registrou a maior preponderância com 17,8% (n=94) e o ano de 2010 a menor com 2,3% (n=12). A cidade de Brasília registrou a maior preponderância com 29,2% (n=154) e Arniqueiras a menor com 0,2% (n=1). A maior preponderância dos registros se constituiu de pessoas do sexo feminino com 95,5% (n=504), 45,8% (n=242) possuíam entre 20 a 29 anos e 65,2% (n=344) dos registros possuíam até um mês entre a data do início do fato a data do registro. Conclusão: Foi possível verificar aumento na frequência de ocorrências policiais no recorte histórico e geográfico analisados.

Objective: to analyze the frequency of police incidents related to sexual harassment in Brasília, Distrito Federal (DF) and administrative regions between 2010 and 2020. Method: Epidemiological, exploratory, descriptive and quantitative study. Data were acquired from the Civil Police of the Federal District (PCDF). Results: 528 records were identified with mean and standard deviation (48±23.9). The year 2019 registered the highest preponderance with 17.8% (n=94) and the year 2010 the lowest with 2.3% (n=12). The city of Brasília registered the greatest preponderance with 29.2% (n=154) and Arniqueiras the smallest with 0.2% (n=1). The greatest preponderance of records consisted of females with 95.5% (n=504), 45.8% (n=242) were between 20 and 29 years old and 65.2% (n=344) of the records they had up to one month between the date of commencement of the fact and the date of registration. Conclusion: It was possible to verify an increase in the frequency of police incidents in the analyzed historical and geographic context.

Objetivo: Analizar la frecuencia de incidentes policiales relacionados con el acoso sexual en Brasilia, Distrito Federal (DF) y regiones administrativas entre 2010 y 2020. Método: Estudio epidemiológico, exploratorio, descriptivo y cuantitativo. Los datos se obtuvieron de la Policía Civil del Distrito Federal (PCDF). Resultados: se identificaron 528 registros con media y desviación estándar (48±23,9). El año 2019 registró la mayor preponderancia con 17,8% (n=94) y el año 2010 la menor con 2,3% (n=12). La ciudad de Brasilia registró la mayor preponderancia con 29,2% (n=154) y Arniqueiras la más pequeña con 0,2% (n=1). La mayor preponderancia de registros estuvo constituida por mujeres con 95,5% (n=504), 45,8% (n=242) tenían entre 20 y 29 años y 65,2% (n=344) de los registros que tenían hasta un mes entre fecha de inicio del hecho y fecha de registro. Conclusión: se pudo constatar un incremento en la frecuencia de incidentes policiales en el contexto histórico y geográfico analizado.

Cirurgias bariátricas realizadas no Brasil, 2011-2019 / Bariatric surgeries performed in Brazil, 2011-2019 / Cirugías bariátricas realizadas en Brasil, 2011-2019

Objetivo: Analisar a frequência de implementação de cirurgias bariátricas (CB) realizadas no "Brasil" entre os anos de "2011 a 2019", ou seja, nove (09) anos. Método: Estudo exploratório, descritivo e de abordagem quantitativa. Os dados foram extraídos junto a Sociedade Brasileira de Cirurgia Bariátrica e Metabólica (SBCBM). Foi implementada análise estatística do tipo descritiva. Os resultados foram apresentados por meio de tabelas explicativas e de gráficos. Resultados: Foi identificado o universo de 493.212 CB realizadas, com média e desvio padrão de (54.801±11.300,2). O ano de 2019 registrou a maior preponderância com 13,9% (n=68.530) e 2011 registrou a menor preponderância com 7% (n=34.629). Foram identificadas 79,9% (n=394.101) CB financiadas pelos Planos de Saúde, 15,3% (n=75.624) pelo SUS e 4,8% (n=23.487) por instituições particulares. Considerações finais: Foi verificado aumento na frequência de registros de CB realizadas no recorte geográfico e histórico analisados.

Objective: To analyze the frequency of implementation of bariatric surgery (CB) performed in "Brazil" between the years "2011 to 2019", that is, nine (09) years. Method: Exploratory, descriptive study with a quantitative approach. The data were extracted from the Brazilian Society of Bariatric and Metabolic Surgery (SBCBM). Descriptive statistical analysis was implemented. The results were presented using explanatory tables and graphs. Results: The universa of 493.212 CB performed was identified, with a mean and standard deviation of (54,801±11,300.2). The year 2019 registered the highest preponderance with 13.9% (n=68.530) and 2011 registered the lowest preponderance with 7% (n=34.629). 79.9% (n=394.101) CB were financed by Health Plans, 15.3% (n=75.624) by SUS and 4.8% (n=23.487) by private institutions. Final considerations: There was an increase in the frequency of CB records made in the analyzed geographical and historical section.

Objetivo: Analizar la frecuencia de implementación de la cirugía bariátrica (CB) realizada en "Brasil" entre los años "2011 a 2019", es decir, nueve (09) años. Método: Estudio exploratorio, descriptivo con enfoque cuantitativo. Los datos fueron extraídos de la Sociedad Brasileña de Cirugía Bariátrica y Metabólica (SBCBM). Se implementó un análisis estadístico descriptivo. Los resultados se presentaron mediante tablas explicativas y gráficos. Resultados: Se identificó el universo de 493,212 CB realizados, con una media y desviación estándar de (54,801±11,300.2). El año 2019 registró la mayor preponderancia con 13,9% (n=68.530) y 2011 registró la menor preponderancia con 7% (n=34.629). 79,9% (n=394,101) CB fueron financiados por Planes de Salud, 15,3% (n=75,624) por SUS y 4,8% (n=23,487) por instituciones privadas. Consideraciones finales: Hubo un aumento en la frecuencia de registros de CB realizados en el tramo geográfico e histórico analizado.

Variantes do vírus SARS-COV-2 causadoras da COVID-19 no Brasil / Variants of the SARS-COV-2 virus that cause COVID-19 in Brazil / Variantes del virus SARS-COV-2 que causan COVID-19 en Brasil

Objetivo: Analisar as variantes do vírus SARS-COV-2 causadoras da COVID-19 no Brasil, identificadas até fevereiro de 2021. Método: Estudo exploratório, descritivo, comparativo e quantitativo. Os dados foram adquiridos no Ministério da Saúde (MS). Resultados: Foram identificadas as variantes "VOC B.1.1.7, VOC202012/01 ou 201/501Y.V1" do Reino Unido, a "VOC B.1.351 ou VOC202012/02 ou 20H/501Y.V2" da África do Sul e a "VOC B.1.1.28.1 ou P.1 ou 20J/501Y.V3" do Brasil/Japão. As variantes VOV P.1 e a VOC B.1.1.7 foram as mais preponderantes do Brasil, com o universo de 334 casos, onde a primeira registrou 89,5% (n=299) e a segunda 10,5% (n=35). A região Nordeste (NE) registrou a maior preponderância das duas variantes contabilizando 32,6% (n=109) e o estado da Paraíba (PB) a maior preponderância da variante VOV P.1 com 23,1% (n=69). Considerações finais: As mutações do vírus SARS-CoV-2, causador da COVID-19, podem ter causado o surgimento de nova linhagem do vírus em circulação no Brasil.

To analyze the variants of the SARS-COV-2 virus that causes COVID-19 in Brazil, identified until february 2021. Method: Exploratory, descriptive, comparative and quantitative study. The data were acquired at the Ministry of Health (MS). Results: The variants "VOC B.1.1.7, VOC202012/01 or 201/501Y.V1" from the United Kingdom, "VOC B.1.351 or VOC202012/02 or 20H/501Y.V2" from South Africa and the "VOC B.1.1.28.1 or P.1 or 20J/501Y.V3" from Brazil/Japan. The VOV P.1 and VOC B.1.1.7 variants were the most prevalent in Brazil, with a universe of 334 cases, where the first registered 89.5% (n=299) and the second 10.5% (n=35). The Northeast region (NE) registered the highest preponderance of the two variants accounting for 32.6% (n=109) and the state of Paraíba (PB) the highest preponderance of the VOV P.1 variant with 23.1% (n=69) . Final considerations: Mutations of the SARS-CoV-2 virus, which causes COVID-19, may have caused the emergence of a new strain of the virus in circulation in Brazil.

Objetivo: Analizar las variantes del virus SARS-COV-2 que causa COVID-19 en Brasil, identificadas hasta febrero de 2021. Método: Estudio exploratorio, descriptivo, comparativo y cuantitativo. Los datos se obtuvieron del Ministerio de Salud (MS). Resultados: las variantes "VOC B.1.1.7, VOC202012/01 o 201/501Y.V1" del Reino Unido, "VOC B.1.351 o VOC202012/02 o 20H/501Y.V2" de Sudáfrica y el "VOC B.1.1.28.1 o P.1 o 20J/501Y.V3" de Brasil/Japón. Las variantes VOV P.1 y VOC B.1.1.7 fueron las más prevalentes en Brasil, con un universo de 334 casos, donde la primera registró 89,5% (n=299) y la segunda 10,5% (n=35). La región Nordeste (NE) registró la mayor preponderancia de las dos variantes con 32,6% (n=109) y el estado de Paraíba (PB) la mayor preponderancia de la variante VOV P.1 con 23,1% (n=69). Consideraciones finales: Las mutaciones del virus SARS-CoV-2, que causa COVID-19, pueden haber causado la aparición de una nueva cepa del virus en circulación en Brasil.

Composition and distribution of fishes from the Perequê-Açu river basin, Paraty, Rio de Janeiro, Southeastern Brazil / Composição e distribuição de peixes da bacia do rio Perequê-Açu, Paraty, Rio de Janeiro, Sudeste do Brasil

Abstract The large number of less-known coastal drainages in the Atlantic Forest still represents an important gap in the knowledge of ichthyofauna. It is evaluated the taxonomic diversity, frequency and constancy of occurrence, and the distribution of species in the various segments of the Perequê-Açu river basin, state of Rio de Janeiro, Brazil. Twelve sampling campaigns resulted in 13,423 individuals, belonging to seven orders, 10 families, 21 genera, and 23 native species. Cyprinodontiformes and Siluriformes represented about 87.2% of the total abundance, mainly due to the contribution of Phalloceros anisophallos and Schizolecis guntheri, which account for 63.2% of the total sampled individuals. The analysis of constancy of occurrence reveals that 78.3% of the drainage species are residents, with approximately 93% of the residents of the Carrasquinho River sub-basin. The Sertões River sub-basin had the largest number of species in total: 18. The rarefaction curve did not reach an asymptote, although Chao 2 and bootstrap estimate the richness of 23.9 species and 23.7 species, respectively. The results of PERMANOVA, PCoA, and SIMPER indicate that the fish composition along the catchment is not homogeneous. The conservation status of species is also discussed, regionally, nationally, and globally.

Resumo O grande número de drenagens costeiras pouco estudadas na Mata Atlântica ainda representa uma lacuna importante no conhecimento da ictiofauna. Avalia-se aqui a diversidade taxonômica, frequência e constância de ocorrência e a distribuição das espécies nos vários segmentos da bacia do rio Perequê-Açu, estado do Rio de Janeiro, Brasil. Doze campanhas de amostragem resultaram em 13.423 indivíduos, pertencentes a sete ordens, 10 famílias, 21 gêneros e 23 espécies nativas. Cyprinodontiformes e Siluriformes representaram cerca de 87,2% da abundância total, devido sobretudo à contribuição de Phalloceros anisophallos e Schizolecis guntheri, que respondem por 63,2% do total de indivíduos amostrados. A análise de constância de ocorrência revela que 78,3% das espécies da drenagem são residentes, sendo cerca de 93% dos residentes da sub-bacia do rio Carrasquinho. A sub-bacia do rio Sertões apresentou o maior número de espécies no total: 18. A curva de rarefação não atingiu uma assíntota, embora Chao 2 e bootstrap estimem a riqueza de 23,9 espécies e 23,7 espécies, respectivamente. Os resultados de PERMANOVA, PCoA e SIMPER indicam que a composição dos peixes ao longo da bacia hidrográfica não é homogênea. Discute-se, ainda, o status de conservação das espécies, regional, nacional e globalmente.

Self-perception of body changes in persons living with HIV/AIDS: prevalence and associated factors.

BACKGROUND: Highly active antiretroviral therapy has brought about a substantial improvement in the prognosis of HIV/AIDS. In this context, therapy-related body changes (lipodystrophy) gain in importance, in light of the psychological distress they cause and of their association with adherence to treatment. This study analyses patients' self-perception of central fat gain (CFG) and peripheral fat loss (PFL). METHODS: A total of 457 patients were interviewed in a university outpatient facility for the treatment of adults and adolescents with HIV/AIDS in the city of São Paulo, Brazil, between September and December 2001. RESULTS: Two-thirds of subjects (64.3%) perceived body changes. The self-perception of CFG and PFL was associated with greater schooling. The self-perception of CFG was more frequent among women and in patients who used protease inhibitors for longer periods. The self-perception of PFL was more frequent among older patients, patients who used stavudine for longer periods, and patients who reported a lack of adherence to antiretroviral agents. The quality of affective/social relationships with friends and family was inversely associated with the self-perception of PFL. CONCLUSION: The evaluation of self-perceived body changes and their determinants in individuals living with HIV/AIDS may help improve provided care. Listening to what patients have to say concerning antiretroviral therapy-related body changes and how they perceive them, as well as including the patient in therapeutic decisions in this regard will contribute towards greater adherence to proposed interventions and towards an improvement in the quality of life.

Intervenção de enfermagem-primeiro banho do recém-nascido: estudo randomizado sobre o comportamento neonatal / Intervención de enfermería-primer baño del recién nacido: estudio aleatorizado sobre el comportamiento neonatal / Nursing intervention-first bath of the NB: a randomized study on neonatal behavior

Resumo Objetivo Avaliar os efeitos da intervenção Enfermagem-primeiro banho sobre o choro e o sono do recém-nascido. Métodos Ensaio clínico randomizado controlado realizado no alojamento conjunto do Hospital Universitário do Espírito Santo (Brasil). A amostra constituiu-se de 33 neonatos a termo. O grupo experimental composto por 18 recém-nascidos recebeu a técnica intervenção de enfermagem-primeiro banho. As variáveis dependentes foram a presença de choro e o tempo de sono após o banho do RN a Intervenção-Primeiro Banho foi definida como variável independente. As variáveis de controle relacionadas ao recém-nascido foram: idade gestacional; peso ao nascimento; peso antes do banho; perda ponderal; dor neonatal; saturação; sinais vitais; temperatura do ambiente; temperatura da água; tempo do banho; e tempo do cuidado corporal por formulário específico após 24 horas de nascimento. Utilizou-se a Escala de Avaliação do Estado de Sono e Vigília, adaptada de Brazelton, a escala de NIPS para avaliação da dor neonatal. Resultados Os recém-nascidos do grupo intervenção do estudo dormiram cerca de 180 minutos, não apresentaram choro durante o experimento, e a avaliação da escala de dor neonatal foi menor. Conclusão A intervenção de enfermagem-primeiro banho pode apresentar melhora no estado comportamental dos recém-nascidos.

Resumen Objetivo Evaluar los efectos de la intervención enfermería-primer baño sobre el llanto y el sueño del recién nacido. Métodos Ensayo clínico aleatorizado controlado, realizado en la internación conjunta del Hospital Universitario de Espírito Santo (Brasil). La muestra consistió en 33 neonatos a término. El grupo experimental compuesto por 18 recién nacidos recibió la técnica intervención de enfermería-primer baño. Las variables dependientes fueron la presencia de llanto y tiempo de sueño después del baño del RN, la intervención-primer baño fue definida como variable independiente. Las variables de control relacionadas con el recién nacido fueron: edad gestacional, peso al nacer, peso antes del baño, pérdida ponderal, dolor neonatal, saturación, signos vitales, temperatura del ambiente, temperatura del agua, tiempo del baño y tiempo del cuidado corporal por formulario específico luego de 24 horas del nacimiento. Se utilizó la Escala de evaluación del estado del sueño y vigilia, adaptada de Brazelton, la escala de NIPS para evaluar el dolor neonatal. Resultados Los recién nacidos del grupo experimental del estudio durmieron cerca de 180 minutos, no presentaron llanto durante el experimento y la evaluación de la escala de dolor neonatal fue menor. Conclusión La intervención de enfermería-primer baño puede presentar mejoras en el estado de comportamiento de los recién nacidos. Número REBEC: U1111-1239-4388

Abstract Objective To assess the effects of nursing intervention-first bath on NB crying and sleep. Methods Randomized controlled clinical trial conducted at the joint accommodation of the University Hospital of the state of Espírito Santo (Brazil). Sample consisted of 33 full-term infants. The experimental group of 18 NBs received the nursing intervention-first bath technique. The dependent variables were the presence of crying and sleep time after the NB's bath. First bath intervention was defined as an independent variable. The control variables related to the NB were: gestational age; birth weight; weight before bath; weight loss; neonatal pain; saturation; vital signs; room temperature; water temperature; bath time; and time of body care by form after 24 hours of birth. We used the Brazelton Sleep and Wake Status Assessment Scale, the NIPS scale for assessing neonatal pain. Results The NBs in the study intervention group slept for about 180 minutes, did not cry during the experiment, and the neonatal pain scale assessment was lower. Conclusion Nursing intervention-first bath may improve NBs' behavioral state. REBEC number: U1111-1239-4388

Suporte social da espiritualidade a idosos, vítimas de violência familiar / Social support of spirituality for the elderly victims of family violence / Apoyo social da espiritualidade a idosos, vítimas de violência familiar

A espiritualidade à velhice em situação de risco é um suporte de enfrentamento. Com o objetivo de identificar a ação da espiritualidade sobre a vida de dez idosos, enquanto suporte em rede social, no contexto de violência familiar, utilizou-se abordagem qualitativa; os instrumentos: Ficha de dados sociodemográficos, Roteiro de entrevistas semiestruturada, Lista de membros da rede social e Mapa de rede; para tratamento de dados: Análise de Conteúdo. Concluiu-se que a espiritualidade é um fator de proteção.

Spirituality in old age at risk is a coping support. In order to identify the action of spirituality on the lives of ten elderly people, as a support in a social network, in the context of family violence, a qualitative approach was used, the instruments Sociodemographic data sheet, Semi-structured interview script, social network and network map. For data processing, Content Analysis. Concluded that spirituality is a factor of protection.

La espiritualidad a la vejez en situación de riesgo es un soporte de enfrentamiento. Con el objetivo de identificar la acción de la espiritualidad sobre la vida de diez ancianos, como soporte en red social, en el contexto de violencia familiar, se utilizó abordaje cualitativo, los instrumentos Ficha de datos sociodemográficos, Ruta de entrevistas semiestructuradas, Lista de miembros de la sociedad red social y Mapa de red. Para el tratamiento de datos, Análisis de contenido. Se concluyó que la espiritualidad es un factor de protección.