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Perovskite light-emitting diodes (PeLEDs) with an external quantum efficiency exceeding 20% have been achieved in both green and red wavelengths1-5; however, the performance of blue-emitting PeLEDs lags behind6,7. Ultrasmall CsPbBr3 quantum dots are promising candidates with which to realize efficient and stable blue PeLEDs, although it has proven challenging to synthesize a monodispersed population of ultrasmall CsPbBr3 quantum dots, and difficult to retain their solution-phase properties when casting into solid films8. Here we report the direct synthesis-on-substrate of films of suitably coupled, monodispersed, ultrasmall perovskite QDs. We develop ligand structures that enable control over the quantum dots' size, monodispersity and coupling during film-based synthesis. A head group (the side with higher electrostatic potential) on the ligand provides steric hindrance that suppresses the formation of layered perovskites. The tail (the side with lower electrostatic potential) is modified using halide substitution to increase the surface binding affinity, constraining resulting grains to sizes within the quantum confinement regime. The approach achieves high monodispersity (full-width at half-maximum = 23 nm with emission centred at 478 nm) united with strong coupling. We report as a result blue PeLEDs with an external quantum efficiency of 18% at 480 nm and 10% at 465 nm, to our knowledge the highest reported among perovskite blue LEDs by a factor of 1.5 and 2, respectively6,7.
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An animal's nervous system changes as its body grows from birth to adulthood and its behaviours mature1-8. The form and extent of circuit remodelling across the connectome is unknown3,9-15. Here we used serial-section electron microscopy to reconstruct the full brain of eight isogenic Caenorhabditis elegans individuals across postnatal stages to investigate how it changes with age. The overall geometry of the brain is preserved from birth to adulthood, but substantial changes in chemical synaptic connectivity emerge on this consistent scaffold. Comparing connectomes between individuals reveals substantial differences in connectivity that make each brain partly unique. Comparing connectomes across maturation reveals consistent wiring changes between different neurons. These changes alter the strength of existing connections and create new connections. Collective changes in the network alter information processing. During development, the central decision-making circuitry is maintained, whereas sensory and motor pathways substantially remodel. With age, the brain becomes progressively more feedforward and discernibly modular. Thus developmental connectomics reveals principles that underlie brain maturation.
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Encéfalo/citología , Encéfalo/crecimiento & desarrollo , Caenorhabditis elegans/citología , Conectoma , Modelos Neurológicos , Vías Nerviosas , Sinapsis/fisiología , Envejecimiento/metabolismo , Animales , Encéfalo/anatomía & histología , Encéfalo/ultraestructura , Caenorhabditis elegans/anatomía & histología , Caenorhabditis elegans/crecimiento & desarrollo , Caenorhabditis elegans/ultraestructura , Individualidad , Interneuronas/citología , Microscopía Electrónica , Neuronas/citología , Conducta EstereotipadaRESUMEN
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered swine coronavirus with potential cross-species transmission risk. Although SADS-CoV-induced host cell apoptosis and innate immunity antagonization has been revealed, underlying signaling pathways remain obscure. Here, we demonstrated that infection of SADS-CoV induced apoptosis in vivo and in vitro, and that viral protein NS7a is mainly responsible for SADS-CoV-induced apoptosis in host cells. Furthermore, we found that NS7a interacted with apoptosis-inducing factor mitochondria associated 1 (AIFM1) to activate caspase-3 via caspase-6 in SADS-CoV-infected cells, and enhanced SADS-CoV replication. Importantly, NS7a suppressed poly(I:C)-induced expression of type III interferon (IFN-λ) via activating caspase-3 to cleave interferon regulatory factor 3 (IRF3), and caspase-3 inhibitor protects piglets against SADS-CoV infection in vivo. These findings reveal how SADS-CoV induced apoptosis to inhibit innate immunity and provide a valuable clue to the development of effective drugs for the clinical control of SADS-CoV infection.IMPORTANCEOver the last 20 years, multiple animal-originated coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), middle east respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2, have caused millions of deaths, seriously jeopardized human health, and hindered social development, indicating that the study of animal-originated coronaviruses with potential for cross-species transmission is particularly important. Bat-originated swine acute diarrhea syndrome coronavirus (SADS-CoV), discovered in 2017, can not only cause fatal diarrhea in piglets, but also infect multiple human cells, with a potential risk of cross-species transmission, but its pathogenesis is unclear. In this study, we demonstrated that NS7a of SADS-CoV suppresses IFN-λ production via apoptosis-inducing factor mitochondria associated 1 (AIFM1)-caspase-6-caspase-3-interferon regulatory factor 3 (IRF3) pathway, and caspase-3 inhibitor (Z-DEVD-FMK) can effectively inhibit SADS-CoV replication and protect infected piglets. Our findings in this study contribute to a better understanding of SADS-CoV-host interactions as a part of the coronaviruses pathogenesis and using apoptosis-inhibitor as a drug as potential therapeutic approaches for prevention and control of SADS-CoV infection.
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Apoptosis , Inmunidad Innata , Factor 3 Regulador del Interferón , Interferones , Proteínas no Estructurales Virales , Animales , Porcinos , Humanos , Interferones/metabolismo , Factor 3 Regulador del Interferón/metabolismo , Proteínas no Estructurales Virales/metabolismo , Replicación Viral , Interferón lambda , Infecciones por Coronavirus/virología , Infecciones por Coronavirus/metabolismo , Alphacoronavirus/metabolismo , Caspasa 3/metabolismo , Enfermedades de los Porcinos/virología , Enfermedades de los Porcinos/metabolismo , Células Vero , Transducción de Señal , Chlorocebus aethiops , Células HEK293RESUMEN
Multimodal integration combines information from different sources or modalities to gain a more comprehensive understanding of a phenomenon. The challenges in multi-omics data analysis lie in the complexity, high dimensionality, and heterogeneity of the data, which demands sophisticated computational tools and visualization methods for proper interpretation and visualization of multi-omics data. In this paper, we propose a novel method, termed Orthogonal Multimodality Integration and Clustering (OMIC), for analyzing CITE-seq. Our approach enables researchers to integrate multiple sources of information while accounting for the dependence among them. We demonstrate the effectiveness of our approach using CITE-seq data sets for cell clustering. Our results show that our approach outperforms existing methods in terms of accuracy, computational efficiency, and interpretability. We conclude that our proposed OMIC method provides a powerful tool for multimodal data analysis that greatly improves the feasibility and reliability of integrated data.
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Análisis de la Célula Individual , Análisis por Conglomerados , Análisis de la Célula Individual/métodos , Biología Computacional/métodos , Humanos , AlgoritmosRESUMEN
High-quality genome of rosemary (Salvia rosmarinus) represents a valuable resource and tool for understanding genome evolution and environmental adaptation as well as its genetic improvement. However, the existing rosemary genome did not provide insights into the relationship between antioxidant components and environmental adaptability. In this study, by employing Nanopore sequencing and Hi-C technologies, a total of 1.17 Gb (97.96%) genome sequences were mapped to 12 chromosomes with 46 121 protein-coding genes and 1265 non-coding RNA genes. Comparative genome analysis reveals that rosemary had a closely genetic relationship with Salvia splendens and Salvia miltiorrhiza, and it diverged from them approximately 33.7 million years ago (MYA), and one whole-genome duplication occurred around 28.3 MYA in rosemary genome. Among all identified rosemary genes, 1918 gene families were expanded, 35 of which are involved in the biosynthesis of antioxidant components. These expanded gene families enhance the ability of rosemary adaptation to adverse environments. Multi-omics (integrated transcriptome and metabolome) analysis showed the tissue-specific distribution of antioxidant components related to environmental adaptation. During the drought, heat and salt stress treatments, 36 genes in the biosynthesis pathways of carnosic acid, rosmarinic acid and flavonoids were up-regulated, illustrating the important role of these antioxidant components in responding to abiotic stresses by adjusting ROS homeostasis. Moreover, cooperating with the photosynthesis, substance and energy metabolism, protein and ion balance, the collaborative system maintained cell stability and improved the ability of rosemary against harsh environment. This study provides a genomic data platform for gene discovery and precision breeding in rosemary. Our results also provide new insights into the adaptive evolution of rosemary and the contribution of antioxidant components in resistance to harsh environments.
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Cromosomas de las Plantas , Genoma de Planta , Genoma de Planta/genética , Cromosomas de las Plantas/genética , Adaptación Fisiológica/genética , Salvia/genética , Salvia/metabolismo , Antioxidantes/metabolismo , Rosmarinus/genética , Rosmarinus/metabolismo , Transcriptoma/genética , Regulación de la Expresión Génica de las Plantas , Depsidos/metabolismo , MultiómicaRESUMEN
This study presents a fast and accurate data processing method for multispectral radiation thermometry that can accurately measure the true temperature of steel materials without requiring a priori emissivity model. The method generates a temperature matrix by inputting emissivity values at different wavelengths and selects a reference vector from the matrix. Then, it rearranges the temperature matrices at other wavelengths and calculates the Euclidean distance between each column element of the rearranged matrix and the reference vector. The method uses an unconstrained optimization technique to minimize the Euclidean distance and obtain the true temperature and emissivity of the object simultaneously. We evaluate the performance of the method by simulation and experiment in the response band of 1.4 â¼ 2.5â µm and temperature range of 873 â¼ 1173 K. The simulation results indicate that the relative error of the inverted temperature is within 0.229%, and the average computation time is less than 112.301 ms. The experimental results show that the maximum temperature error during the measurement process is 0.813%. Our method provides a feasible and efficient solution for real-time temperature measurement of steel materials.
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Optical resonators made of 2D photonic crystal (PhC) slabs provide efficient ways to manipulate light at the nanoscale through small group-velocity modes with low radiation losses. The resonant modes in periodic photonic lattices are predominantly limited by nonleaky guided modes at the boundary of the Brillouin zone below the light cone. Here, we propose a mechanism for ultra-high Q resonators based on the bound states in the continuum (BICs) above the light cone that have zero-group velocity (ZGV) at an arbitrary Bloch wavevector. By means of the mode expansion method, the construction and evolution of avoided crossings and Friedrich-Wintgen BICs are theoretically investigated at the same time. By tuning geometric parameters of the PhC slab, the coalescence of eigenfrequencies for a pair of BIC and ZGV modes is achieved, indicating that the waveguide modes are confined longitudinally by small group-velocity propagation and transversely by BICs. Using this mechanism, we engineer ultra-high Q nanoscale resonators that can significantly suppress the radiative losses, despite the operating frequencies above the light cone and the momenta at the generic k point. Our work suggests that the designed devices possess potential applications in low-threshold lasers and enhanced nonlinear effects.
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In metal smelting, precise temperature control is of vital importance for reaction rates, efficiency, and product quality. Traditional methods such as thermocouples have inherent limitations, but multispectral radiation thermometry (MRT) offers high resolution and reliability. This paper proposes a multispectral radiation thermometry platform featuring wireless data transmission, which enables remote data transfer and precise temperature measurements. The platform was meticulously calibrated, and six common emissivity models were inverted with high accuracy. The results of temperature measurements conducted at a copper smelting site demonstrated an excellent degree of agreement with those obtained using disposable thermocouples. The platform has the potential to be applied in harsh environments, offering, to our knowledge, a novel approach to temperature measurement in metal smelting processes.
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To concurrently determine the thermophysical parameters of semi-transparent materials, a novel, to the best of our knowledge, integrated approach for concurrent measurement is proposed. In the measurement setup, a high-temperature radiation source and a beam reducer are employed to minimize the influence of background radiation. In order to differentiate between the transmitted and emitted radiation in the detection signal, the radiation signals from the radiation source are measured under four different conditions, enabling the calculation of transmissivity, emissivity, and reflectivity. The reliability and accuracy of the measurement method are validated by the thermophysical parameters of sapphire, and the results demonstrate a strong agreement between the measured data and previous findings. The combined uncertainties of transmissivity and emissivity for the sapphire at 753â K are estimated, highlighting the novel contribution of this method in investigating the thermophysical parameters of semi-transparent materials.
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OBJECTIVE: Cystic echinococcosis (CE) represents a profoundly perilous zoonotic disease. The advent of viral macrogenomics has facilitated the exploration of hitherto uncharted viral territories. In the scope of this investigation, our objective is to scrutinize disparities in the intestinal microbiotic ecosystems of canines dwelling in elevated terrains and those afflicted by Echinococcus infection, employing the tool of viral macrogenomics. METHODS: In this study, we collected a comprehensive total of 1,970 fecal samples from plateau dogs infected with Echinococcus, as well as healthy control plateau dogs from the Yushu and Guoluo regions in the highland terrain of China. These samples were subjected to viral macrogenomic analysis to investigate the viral community inhabiting the canine gastrointestinal tract. RESULTS: Our meticulous analysis led to the identification of 136 viral genomic sequences, encompassing eight distinct viral families. CONCLUSION: The outcomes of this study hold the potential to enhance our comprehension of the intricate interplay between hosts, parasites, and viral communities within the highland canine gut ecosystem. Through the examination of phage presence, it may aid in early detection or assessment of infection severity, providing valuable insights into Echinococcus infection and offering prospects for potential treatment strategies.
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Enfermedades de los Perros , Equinococosis , Echinococcus , Heces , Microbioma Gastrointestinal , Animales , Perros , Equinococosis/veterinaria , Enfermedades de los Perros/parasitología , Enfermedades de los Perros/microbiología , Enfermedades de los Perros/virología , China , Heces/parasitología , Heces/microbiología , Heces/virología , Echinococcus/genética , Echinococcus/aislamiento & purificación , Genoma Viral , Virus/clasificación , Virus/aislamiento & purificación , Virus/genéticaRESUMEN
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel porcine enteric coronavirus that causes acute watery diarrhea, vomiting, and dehydration in newborn piglets. The type III interferon (IFN-λ) response serves as the primary defense against viruses that replicate in intestinal epithelial cells. However, there is currently no information available on how SADS-CoV modulates the production of IFN-λ. In this study, we utilized IPI-FX cells (a cell line of porcine ileum epithelium) as an in vitro model to investigate the potential immune evasion strategies employed by SADS-CoV against the IFN-λ response. Our results showed that SADS-CoV infection suppressed the production of IFN-λ1 induced by poly(I:C). Through screening SADS-CoV-encoded proteins, nsp1, nsp5, nsp10, nsp12, nsp16, E, S1, and S2 were identified as antagonists of IFN-λ1 production. Specifically, SADS-CoV nsp1 impeded the activation of the IFN-λ1 promoter mediated by MAVS, TBK1, IKKε, and IRF1. Both SADS-CoV and nsp1 obstructed poly(I:C)-induced nuclear translocation of IRF1. Moreover, SADS-CoV nsp1 degraded IRF1 via the ubiquitin-mediated proteasome pathway without interacting with it. Overall, our study provides the first evidence that SADS-CoV inhibits the type III IFN response, shedding light on the molecular mechanisms employed by SADS-CoV to evade the host immune response.
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Alphacoronavirus , Infecciones por Coronavirus , Enfermedades de los Porcinos , Animales , Porcinos , Complejo de la Endopetidasa Proteasomal , Interferón lambda , Alphacoronavirus/fisiología , Ubiquitinas , Infecciones por Coronavirus/veterinariaRESUMEN
Litter size in sheep is a complex trait controlled by micro-effective polygenes. APAF1, CLSTN2, CTH, PLCB1, PLCB4, and CHST11 are all involved in mammalian reproduction. However, the effects of these genes on litter size in sheep are still unclear. Therefore, in this study, we used Sequenom MassARRAY® SNP assay technology to type the single nucleotide polymorphisms (SNPs) loci of six genes in five sheep breeds. The results showed that most sheep breeds contain three genotypes at each locus. Then, we conducted population genetic analysis on the SNPs of six genes and found that the polymorphic information content in all sheep breeds ranged from 0 to 0.37, and most sheep breeds were in Hardy-Weinberg equilibrium (p > 0.05). In addition, association analysis in Small Tail Han sheep indicated that the rs399534524 locus in CLSTN2 was highly associated with first parity litter size, and litter size in ewes with CT genotype was higher than that in ewes with CC genotype or TT genotype. Furthermore, the rs407142552 locus in CTH was highly associated with second parity litter size in Small Tail Han sheep, and litter size in ewes with CT genotype was higher than that in ewes with TT genotype. Finally, we predicted the CTH and CLSTN2 protein interaction network and found that HTR1E, NOM1, CCDC174 and ALPK3 interact with CLSTN2 and have been reported as candidate genes related to litter size in sheep. These results suggest that they may be useful genetic markers for increasing litter size in sheep.
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Mamíferos , Polimorfismo de Nucleótido Simple , Ovinos , Animales , Femenino , Embarazo , Tamaño de la Camada/genética , GenotipoRESUMEN
Magneto-plasmon sensors based on the transverse magneto-optical Kerr effect (TMOKE) have been extensively studied in recent years. In this paper, we theoretically propose a hybrid structure composed of a one-dimensional bismuth iron garnet: yttrium iron garnet (BIG: YIG) nanowire arrays and thin film stack, which is grown on an infinite thick silicon wafer. The thin film stack, from top to bottom, consists of the following layers: BIG: YIG, SiO2, and Au. By exciting the magnetic dipole resonance mode between the cylindrical nanowires and the SPP mode on the surface of the Au film, dual-channel sensing has been achieved in both visible and infrared spectra. The results demonstrate that the TMOKE response spectrum of the structure supports ultra-narrow linewidths of 0.03â nm in the visible light range and 1.54â nm in the infrared range. By changing the refractive index of the analyte, the detected sensitivity of the sensor system in visible and infrared bands is 553â nm RIU-1 and 285â nm RIU-1, and the Figure of merit (FOM) can reach up to 69125 RIU-1 and 303 RIU-1, respectively. This work provides a theoretical basis and a feasible approach for the design of dual channel gas sensors.
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The unknown emissivity still poses a significant challenge in the data processing of Multispectral radiation thermometry (MRT). In order to achieve global optimal solution with fast convergence speed and strong robustness, a systematic comparative analysis of particle swarm optimization (PSO) and simulated annealing (SA) algorithms in the application in MRT is presented in this paper. The simulations of six hypothetical emissivity models were compared, and the results indicate that the PSO algorithm is superior to the SA algorithm in accuracy, efficiency and stability. The measured data of the surface temperature of rocket motor nozzle is simulated by the PSO algorithm, the maximum absolute error and the maximum relative error are 16.27â K and 0.65%, and the calculation time is less than 0.3 s. The superior performance of the PSO algorithm indicates that it can be well used in data processing for accurate temperature measurement in MRT, and the method proposed in this paper can be extended to other multispectral systems and applied to various industrial processes under high temperature conditions.
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Monolayer direct-band gap transition metal dichalcogenides (TMDCs) have been extensively investigated in the context of light-matter interactions. To reach strong coupling, these studies make use of external optical cavities supporting well-defined resonant modes. However, use of an external cavity might limit the scope of possible applications of such systems. Here, we demonstrate that thin films of TMDCs can themselves serve as high-quality-factor cavities due to the guided optical modes they sustain in the visible and near-infrared ranges. Making use of the prism coupling, we achieve the strong coupling between excitons and guided-mode resonances lying below the light line, and show that the thickness of TMDC membranes can be used to tune and promote photon-exciton interactions within the strong-coupling regime. Additionally, we demonstrate narrowband perfect absorption in thin TMDC films through critical coupling with guided-mode resonances. Our work not only provides a simple and intuitive picture to tame interaction of light and matter in thin TMDC films, but also suggests that these simple systems are a promising platform for realizing polaritonic and optoelectronic devices.
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In this paper, what we believe to be, a new combined algorithm of artificial bee colony and slime mould algorithm (CABCSMA) and a differential evolution (DE) algorithm using target-to-best variation strategy are proposed to process the data based on Planck's radiation law and the mathematical model of reference temperature. The material model with 6 different emissivity trends is simulated. Simulation results show that the average relative error of CABCSMA algorithm is less than 0.68%, and the average calculation time is 0.44s. The average relative error of DE algorithm is less than 0.43%, and the average calculation time is only 0.06s. The two algorithms were applied to the temperature test of silicon carbide sample, tungsten material and rocket engine nozzle. The experimental results show that the relative error of silicon carbide experimental temperature is less than 0.41% and 0.28%, and the relative error of tungsten material experimental temperature is less than 0.31% and 0.3%. The relative errors of rocket engine nozzle temperature experiments are within 0.68% and 0.52%, respectively. The results show that these two algorithms are expected to be applied in practical measurement scenarios.
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Accurate temperature measurement has significant implications for product quality, industrial process control, and scientific research. As a non-contact temperature measurement method with broad application prospects, multispectral thermometry still poses significant challenges in data processing. Currently, most multispectral thermometry methods use the Wien approximation equation to construct the objective function. However, the use of the Wien approximation equation is conditional and generally applicable only to low temperatures or short wavelengths. In this paper, what we believe is a new data processing model of multispectral thermometry is established based on the Planck formula; Additionally, a feasible region constraint method is proposed to constrain the emissivity range; By utilizing a hybrid metaheuristic optimization algorithm based on differential evolution (DE) and multi-population genetic (MPG) algorithms, the simulation results of six different models and experimental results of silicon carbide demonstrate that the proposed algorithm achieves an average relative error in temperature measurement within 0.42% and a random relative error within 0.79%. The average computation time for each temperature inversion is approximately 0.26 seconds. The accuracy and efficiency of the algorithm ensure that it can be applied to real-time temperature measurement in industrial field.
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The concept of symmetry-protected bound states in the continuum (BICs) offers a simple approach to engineer metasurfaces with high-quality (Q) factors. However, traditional designs driven by symmetry-protected BICs require an extremely small perturbation parameter to obtain very large Q factors, complicating fabrication and limiting practical applications. Here, we demonstrate a BIC-driven structure composed of two coupled all-dielectric metasurfaces that enables ultrahigh-Q resonances even at large perturbations. The underlying mechanism enabling this is to merge the symmetry-protected BIC and Fabry-Pérot BIC in the parameter space by tuning the distance between the two metasurfaces, thereby altering the intrinsic radiation behavior of the isolated symmetry-protected BIC. It is found that this simple strategy results in Q factors that are three orders of magnitude higher than those with isolated-BIC configurations. Our approach provides a promising route for designing high-Q BIC nanostructures promising in exciting device applications as sensors and filters.
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Melatonin (MLT) protects cells by reducing reactive oxygen species (ROS) levels, which are key for inducing cellular autophagy. The aim of this study was to investigate the molecular mechanisms underlying MLT regulation of autophagy in granulosa cells (GCs) with BMPR-1B homozygous (FecB BB) and wild type (FecB ++) mutations. GCs collected from small-tailed Han sheep with different FecB genotypes were typed using a TaqMan probe assay, and autophagy levels were found to be significantly higher in GCs with FecB BB than the levels in those with FecB ++. Autophagy-related 2 homolog B (ATG2B) was associated with cell autophagy and was highly expressed in GCs with the FecB BB genotype in small-tailed Han sheep. Overexpression of ATG2B in the GCs of sheep with both FecB genotypes promoted GC autophagy, and the contrary was observed after the inhibition of ATG2B expression. Subsequently, treatment of GCs with different genotypes of FecB and MLT revealed a significant decrease in cellular autophagy and an increase in ATG2B expression. Addition of MLT to GCs with inhibited ATG2B expression revealed that MLT could protect GCs by decreasing ROS levels, especially in GCs with FecB ++ genotype. In conclusion, this study determined that autophagy levels were significantly higher in sheep GCs with FecB BB genotype than the levels in those with FecB ++ genotype, which may have contributed to the difference in lambing numbers between the two FecB genotypes. Autophagy was regulated by ATG2B and was able to protect GCs by reducing the high levels of ROS produced following inhibition of ATG2B through the addition of MLT in vitro.
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Melatonina , Femenino , Animales , Ovinos , Melatonina/farmacología , Melatonina/metabolismo , Especies Reactivas de Oxígeno/metabolismo , Células de la Granulosa , Genotipo , AutofagiaRESUMEN
The development of singlet fission (SF) is greatly hindered by the severe shortage of the types and numbers of SF materials. Here, essential energy conditions and SF-related competitive processes of a series of BPEA derivatives, which are a kind of new promising SF material, are investigated theoretically. Encouraging advantages and interesting laws of key energy conditions of those derivatives were found and potential BPEA derivatives were predicted. Those derivatives present mild exothermic SF processes with 0.3-0.4 eV free energies (ΔE(S1-2T1)) consistently. Their lowest triplet states (T1) are stable and totally enter into the ideal energy window (≥1.0 eV), which is beneficial for achieving the maximum efficiency of PCE. Their large ΔE(T2-2T1) can suppress the higher-state annihilation of T1 well. The E(S1) and ΔE(S1-2T1) of the derivatives are sensitive to both the slip patterns of the dimer and ending substituents. Terminal substituents with both strong electron-withdrawing and electron-donating abilities can lower E(S1), and decreases in the former are more obvious due to the larger intramolecular charge transfer. Interestingly, it is found firstly that the terminal substituent modulation effect on E(S1) and ΔE(S1-2T1) is more effective when large longitudinal slips are included in their stacking modes. The reason is that the direction of the transition dipole moments (µs1) is along X, and large longitudinal slips will bring about the approach of positive and negative charge centers of monomers, and lead to large Davydov splitting. By further evaluation of important radiation and non-radiation processes, it is predicted that the BPEA-based derivatives, which have rigid -Cl, -Br, or -CN terminals and include large longitudinal slips in their crystal packing, are expected to achieve excellent SF performances. Our work provides useful ideas for developing or optimizing acene-derivative SF materials with high efficiency.