Asunto(s)
Anestésicos Locales/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Eritema/inducido químicamente , Hemorroides/tratamiento farmacológico , Tetracaína/efectos adversos , Nalgas , Dibucaína/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Pomadas/efectos adversos , SíndromeAsunto(s)
Neoplasias de la Mama/diagnóstico , Hemangiosarcoma/diagnóstico , Radioterapia/efectos adversos , Neoplasias Cutáneas/diagnóstico , Anciano , Neoplasias de la Mama/etiología , Neoplasias de la Mama/radioterapia , Femenino , Hemangiosarcoma/etiología , Humanos , Neoplasias Cutáneas/etiologíaAsunto(s)
Alérgenos/efectos adversos , Cosméticos/efectos adversos , Dermatitis Alérgica por Contacto/diagnóstico , Dermatosis del Pie/diagnóstico , Morfolinas/efectos adversos , Uñas , Adulto , Dermatitis Alérgica por Contacto/etiología , Dermatitis Alérgica por Contacto/patología , Diagnóstico Diferencial , Femenino , Dermatosis del Pie/inducido químicamente , Dermatosis del Pie/patología , Humanos , Pruebas del ParcheAsunto(s)
Antibióticos Antineoplásicos/efectos adversos , Hipersensibilidad a las Drogas/etiología , Mitomicina/efectos adversos , Prurito/inducido químicamente , Enfermedades de la Vulva/inducido químicamente , Administración Intravesical , Anciano , Antibióticos Antineoplásicos/administración & dosificación , Carcinoma de Células Transicionales/tratamiento farmacológico , Femenino , Humanos , Mitomicina/administración & dosificación , Pruebas del Parche , Neoplasias de la Vejiga Urinaria/tratamiento farmacológicoRESUMEN
Churg-Strauss syndrome (CSS), also known as allergic granulomatous angiitis, is a rare disorder characterized by the presence of asthma, eosinophilia and small-to-medium sized vessels vasculitis. Vasculitis commonly affects lung, heart, skin and peripheral nerves. The authors report a case of a 47-year-old woman that was admitted with a 1-week history of painful purpuric lesions affecting extensor surfaces of lower extremities. She had a 7 years-long medical history of asthma, paranasal sinusitis and allergic rhinitis. Laboratorial tests revealed leucocytosis, peripheral blood eosinophilia and elevated inflammatory parameters. Antineutrophil cytoplasmic antibodies were negative. Skin biopsy was consistent with necrotizing vasculitis with perivascular eosinophil-rich infiltrate. Electromyogram and nerve conduction studies showed asymmetrical peripheral polyneuropathy. Churg-Strauss syndrome diagnosis was supported by clinical and histopathological findings. High-dose oral steroid therapy led to a dramatic clinical improvement. Skin manifestations can be the presenting feature of Churg-Strauss syndrome. Early recognition is essential for appropriate treatment and prevention of irreversible organ damage.
Asunto(s)
Síndrome de Churg-Strauss/complicaciones , Vasculitis Leucocitoclástica Cutánea/etiología , Síndrome de Churg-Strauss/diagnóstico , Femenino , Humanos , Persona de Mediana EdadRESUMEN
Acute generalized exanthematous pustulosis (AGEP) usually presents with the acute appearance of oedematous and erythematous lesions, on which multiple sterile pustules appear, associated with fever. Almost 90% of cases are associated with drugs, with antibiotics (penicillins and macrolides) being the most frequent causative agents. We describe a 36-year-old female patient, which started diltiazem 120mg/day for hypertension. After 6 days of therapy, multiple erythematous and oedematous lesions appeared, with associated multiple small non-follicular pustules. Oral corticosteroids were started, with progressive and complete improvement. Patch-tests were performed, which revealed positivity for diltiazem. Although a rare entity, AGEP must be considered in cases of acute eruptions with disseminated pustules and fever. The use of patch tests in this disease may be useful as positive reactions are frequent.