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1.
Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds.
Bioorg Med Chem Lett
; 50: 128342, 2021 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34461178
2.
Discovery and optimization of a novel CNS penetrant series of mGlu4 PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model.
Bioorg Med Chem Lett
; 37: 127838, 2021 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33556572
3.
Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity.
Bioorg Med Chem Lett
; 30(13): 127212, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32371100
4.
Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4).
Bioorg Med Chem Lett
; 26(13): 2984-2987, 2016 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27234146
5.
Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu4).
J Med Chem
; 62(1): 342-358, 2019 01 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30247901
6.
Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease.
ACS Med Chem Lett
; 10(3): 255-260, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891122
7.
Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines.
ACS Med Chem Lett
; 8(10): 1110-1115, 2017 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29057060
8.
VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides.
ACS Med Chem Lett
; 8(12): 1326-1330, 2017 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29259756
9.
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.
ACS Chem Neurosci
; 7(9): 1201-11, 2016 09 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-27441572
10.
Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.
J Med Chem
; 58(18): 7485-500, 2015 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26335039
11.
Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links.
Chem Commun (Camb)
; 47(39): 10915-7, 2011 Oct 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-21691623
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