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1.
Can Vet J ; 64(6): 524-528, 2023 06.
Artículo en Inglés | MEDLINE | ID: mdl-37265810

RESUMEN

Adenoviral hemorrhagic disease (AHD), caused by deer atadenovirus A (OdAdV-1), affects captive and free-ranging cervids across North America. Here we present a case of AHD in a 6-month-old female elk calf from a farm in Alberta. Histopathology revealed multisystemic vasculitis with endothelial intranuclear inclusion bodies, pulmonary hemorrhage, and small intestinal hemorrhage characteristic of the acute systemic form of AHD. Immunohistochemistry was positive for OdAdV-1, confirming the diagnosis. Whole-genome sequencing of the virus was conducted for phylogenetic comparison. This is the 1st reported case of AHD in a farmed elk in Canada and the 1st reported case in an elk in Alberta. Key clinical message: Adenoviral hemorrhagic disease (AHD) is an emerging disease that should be investigated as a top differential when diagnosticians and veterinarians encounter young cervids found dead with pulmonary edema or hemorrhage and/or hemorrhagic enteropathy.


Maladie hémorragique adénovirale chez un wapiti d'élevage (Cervus canadensis) en Alberta, Canada. La maladie hémorragique adénovirale (AHD), causée par l'atadénovirus A du cerf (OdAdV-1), affecte les cervidés en captivité et en liberté partout en Amérique du Nord. Nous présentons ici un cas d'AHD chez un wapiti femelle de 6 mois d'une ferme en Alberta. L'histopathologie a révélé une vascularite multi-systémique avec des corps d'inclusion intranucléaires endothéliaux, une hémorragie pulmonaire et une hémorragie de l'intestin grêle caractéristiques de la forme systémique aiguë de l'AHD. L'immunohistochimie était positive pour OdAdV-1, confirmant le diagnostic. Le séquençage du génome entier du virus a été réalisé à des fins de comparaison phylogénétique. Il s'agit du premier cas signalé d'AHD chez un wapiti d'élevage au Canada et du premier cas signalé chez un wapiti en Alberta.Message clinique clé :La maladie hémorragique adénovirale (AHD) est une maladie émergente qui devrait être investiguée comme un diagnostic différentiel important lorsque les diagnosticiens et les vétérinaires rencontrent de jeunes cervidés trouvés morts avec un œdème pulmonaire ou une hémorragie et/ou une entéropathie hémorragique.(Traduit par Dr Serge Messier).


Asunto(s)
Ciervos , Animales , Femenino , Alberta/epidemiología , Filogenia , Granjas , Hemorragia/veterinaria
2.
Dev Med Child Neurol ; 61(12): 1423-1431, 2019 12.
Artículo en Inglés | MEDLINE | ID: mdl-31206183

RESUMEN

AIM: To develop an easily-administered metric to quantify gait impairment in children and to assess its use in children with cerebral palsy (CP). METHOD: The Pediatric Temporal-spatial Deviation Index (TDI) was developed from gait data collected from 75 typically developing children (37 males, 38 females; mean age 9y 4mo; interquartile range [IQR] 8-10y) and 17 children diagnosed with spastic CP (nine males, eight females; mean age 9y 9mo; IQR 9-11y), in Gross Motor Function Classification System (GMFCS) levels I to III, aged 7 to 11 years. Children walked on a pressure-sensitive mat. Children with CP also completed 3D gait analysis. The Kaiser-Meyer-Olkin test of sampling adequacy was used for temporal-spatial feature selection. Principal components obtained from temporal-spatial gait parameters quantified deviation from typically developing gait. Deviation was normalized to a Pediatric TDI score mean (standard deviation [SD]) of 100 (10). The Pediatric TDI for children with CP was compared to 3D motion capture-based Gait Deviation Index (GDI). RESULTS: The Pediatric TDI was significantly lower for children with CP compared to typically developing children (p<0.001), correlated with average GDI (r=0.610, p=0.009), and demonstrated sensitivity (0.78) and specificity (0.88) to gait function, assessed with GDI. INTERPRETATION: The Pediatric TDI is an easily administered, revealing gait metric that can be used in children with CP in pediatric clinics and for research. Detection of gait abnormalities in the clinic can expedite diagnosis and treatment. What this paper adds The Pediatric Temporal-spatial Deviation Index (TDI) is a single-score index of gait deviation, based on nine parameters. The Pediatric TDI was more revealing than single temporal-spatial gait parameters. The Pediatric TDI is quick and simple to administer in the clinic.


Asunto(s)
Parálisis Cerebral/diagnóstico , Trastornos Neurológicos de la Marcha/diagnóstico , Índice de Severidad de la Enfermedad , Fenómenos Biomecánicos , Parálisis Cerebral/complicaciones , Parálisis Cerebral/fisiopatología , Niño , Femenino , Trastornos Neurológicos de la Marcha/etiología , Trastornos Neurológicos de la Marcha/fisiopatología , Humanos , Masculino
3.
Occup Ther Health Care ; 28(4): 394-409, 2014 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-25050985

RESUMEN

Understanding unique perspectives from key stakeholder groups involved in the hand control (HC) industry, including driver rehabilitation specialists (DRSs) who train users how to use their HCs, dealers/installers, and users, may become increasingly important in the United States due to increases in elderly, diabetic, and wounded warrior amputee driving populations. In this exploratory study, phone interviews were conducted with 20 DRSs, 20 dealers/installers, and 20 users regarding their perspectives about HC training, maintenance and operation, and design improvements. Results revealed common views and differences in perspectives about whether HC users should receive training and for how long, when and how often users should receive maintenance on their HCs, and what DRSs, dealers/installers, and users would like to see in the future.


Asunto(s)
Conducción de Automóvil , Automóviles , Mano , Necesidades y Demandas de Servicios de Salud , Terapia Ocupacional , Personas con Discapacidad , Educación Especial , Humanos
4.
Front Hum Neurosci ; 18: 1445793, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39359619

RESUMEN

Identification of neuromuscular impairments in cerebral palsy (CP) is essential to providing effective treatment. However, clinical recognition of neuromuscular impairments in CP and their contribution to gait abnormalities is limited, resulting in suboptimal treatment outcomes. While CP is the most common childhood movement disorder, clinical evaluations often do not accurately identify and delineate the primary neuromuscular and secondary musculoskeletal impairments or their specific impact on mobility. Here we discuss the primary neuromuscular impairments of CP that arise from early brain injury and the progressive secondary musculoskeletal impairments, with a focus on spastic CP, the most common form of CP. Spastic CP is characterized by four primary interrelated neuromuscular impairments: 1. muscle weakness, 2. short muscle-tendon units due to slow muscle growth relative to skeletal growth, 3. muscle spasticity characterized by increased sensitivity to stretch, and 4. impaired selective motor control including flexor and extensor muscle synergies. Specific gait events are affected by the four primary neuromuscular impairments of spastic CP and their delineation can improve evaluation to guide targeted treatment, prevent deformities and improve mobility. Emerging information on neural correlates of neuromuscular impairments in CP provides the clinician with a more complete context with which to evaluate and develop effective treatment plans. Specifically, addressing the primary neuromuscular impairments and reducing secondary musculoskeletal impairments are important treatment goals. This perspective on neuromuscular mechanisms underlying gait abnormalities in spastic CP aims to inform clinical evaluation of CP, focus treatment more strategically, and guide research priorities to provide targeted treatments for CP.

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