Detalles de la búsqueda
1.
Pharmacokinetics of oseltamivir phosphate and oseltamivir carboxylate in non-pregnant and pregnant rhesus monkeys.
Regul Toxicol Pharmacol
; 112: 104569, 2020 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-31927005
2.
PBPK model reporting template for chemical risk assessment applications.
Regul Toxicol Pharmacol
; 115: 104691, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-32502513
3.
Characterization of the modes of action and dose-response relationship for thiocyanate on the thyroid hormone levels in rats using a computational approach.
Toxicol Appl Pharmacol
; 365: 84-100, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30639275
4.
Thiocyanate: a review and evaluation of the kinetics and the modes of action for thyroid hormone perturbations.
Crit Rev Toxicol
; 47(7): 537-563, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28632039
5.
Development of a PBPK model of thiocyanate in rats with an extrapolation to humans: A computational study to quantify the mechanism of action of thiocyanate kinetics in thyroid.
Toxicol Appl Pharmacol
; 307: 19-34, 2016 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27445130
6.
Predicting Clinical Pharmacokinetics/Pharmacodynamics and Impact of Organ Impairment on siRNA-Based Therapeutics Using a Mechanistic Physiologically-Based Pharmacokinetic-Pharmacodynamic Model.
Clin Pharmacol Ther
; 115(5): 1054-1064, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38282246
7.
A Mechanistic Physiologically-Based Pharmacokinetic Platform Model to Guide Adult and Pediatric Intravenous and Subcutaneous Dosing for Bispecific T Cell Engagers.
Clin Pharmacol Ther
; 115(3): 457-467, 2024 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37746860
8.
An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science.
Toxics
; 11(2)2023 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36851001
9.
Extrapolation of hypothalamic-pituitary-thyroid axis perturbations and associated toxicity in rodents to humans: case study with perchlorate.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
; 30(1): 81-105, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22458857
10.
Evaluation of a rapid, generic human gestational dose model.
Reprod Toxicol
; 113: 172-188, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36122840
11.
Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues.
Birth Defects Res
; 114(16): 1037-1055, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35532929
12.
IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making.
Toxics
; 10(5)2022 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35622645
13.
Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges.
Biochem Pharmacol
; 189: 114468, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33577889
14.
Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data.
Front Pharmacol
; 12: 692442, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34539393
15.
If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?
Drug Metab Dispos
; 38(2): 260-9, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19889884
16.
Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy.
NPJ Syst Biol Appl
; 6(1): 36, 2020 11 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33159093
17.
Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives.
Environ Int
; 126: 659-671, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30856453
18.
Capturing the applicability of in vitro-in silico membrane transporter data in chemical risk assessment and biomedical research.
Sci Total Environ
; 645: 97-108, 2018 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30015123
19.
In vitro to in vivo extrapolation for high throughput prioritization and decision making.
Toxicol In Vitro
; 47: 213-227, 2018 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-29203341
20.
Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology.
Genes Nutr
; 12: 22, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28904640