RESUMEN
[Figure: see text].
Asunto(s)
Neoplasias del Sistema Nervioso Central/patología , Hemangioma Cavernoso del Sistema Nervioso Central/patología , Propranolol/farmacología , Animales , Modelos Animales de Enfermedad , Femenino , Masculino , Ratones , Ratones NoqueadosRESUMEN
The elastic modulus at the single trabecular level is an important parameter for the understanding of the mechanical behavior of trabecular bone. Current methods are commonly limited by the irregular trabecular shape and the accuracy of displacement measurement. The aim of this study was to propose a method to estimate the trabecular modulus overcoming some of these limitations. For high-precision displacement measurements, in-situ compression within a synchrotron radiation based X-ray tomograph was used. Trabecular displacements were subsequently estimated by a global digital volume correlation algorithm, followed by high-resolution finite element analyses to account for the irregular geometry. The trabecular elastic moduli were then estimated by comparing the loads from the finite element analyses with those of the experiments. With this strategy, the average elastic modulus was estimated to 3.83 ± 0.54 GPa for three human trabeculae samples. Though limited by the sample size, the demonstrated method shows a potential to estimate the mechanical properties at the single trabecular level.