The Complexity of Neuropathic Pain and Central Sensitization: Exploring Mechanisms and Therapeutic Prospects.

Neuropathic pain is a common pain syndrome, which seriously affects the quality of life of patients. The mechanism of neuropathic pain is complex. Peripheral tissue injury can trigger peripheral sensitization; however, what really plays a key role is the sensitization of the central nervous system. Central sensitization is a key factor in the perception of chronic pain. Central sensitization refers to the increased sensitivity of the central nervous system to pain treatment, which is related to the change of the functional connection mode of the neural network. The current study aims to reveal the basic molecular mechanisms of central sensitization, including the involvement of P2 purine X4 receptor and brain-derived neurotrophic factor. In terms of treatment, although there are drugs and physical therapy, the accuracy of targeting is limited and the efficacy needs to be further improved. Future therapeutic strategies may involve the development of new drugs designed to specifically inhibit the central sensitization process. This article focuses on the effector molecules involved in central sensitization, aiming to elucidate the pathogenesis of neuropathic pain and provide a basis for the development of more effective treatment models.

Evaluating the impact of traditional chinese health exercises on adolescent mental health: a systematic review and meta

Under the background of the rapid development of The Times, the material conditions, living standards and education level of teenagers have been greatly improved, so the healthy development of teenagers is easily affected by the external environment. In a rapidly developing society, adolescents are affected by academic burden, changes in lifestyle, and stress from family patterns, which bring major challenges to the development of adolescent mental health. Psychological problems such as depression, anxiety and social phobia are on the rise among teenagers. Early educators pay more attention to the development of adolescent mental health, but with the increasing prominence of adolescent mental health problems, mental health is a special aspect of today's society and the country pays more attention to. To this end, promoting the development of adolescent mental health has become the research direction of many experts and scholars, many of which will focus on the field of sports, because sports have better operability, mass and fun, experts and scholars expect to improve the mental health problems of adolescents through sports. Cuju is a traditional Chinese health sport, which consists of kicking, touching and kicking. Based on the integration of systematic review and meta-analysis, this paper reviewed the research on the influence of Cuju on adolescents' mental health, and confirmed the intervention effect of traditional Chinese ball games on adolescents'mental health through research. Objective: To explore the influencing factors of the effect of ball game intervention on adolescent mental health. (AU)