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1.
Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.
Bioorg Med Chem Lett
; 21(21): 6348-52, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21955943
2.
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Bioorg Med Chem Lett
; 19(17): 5209-13, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19631533
3.
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Bioorg Med Chem Lett
; 19(15): 4092-6, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19539468
4.
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Bioorg Med Chem Lett
; 19(15): 4088-91, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19540112
5.
The experimental type 2 diabetes therapy glycogen phosphorylase inhibition can impair aerobic muscle function during prolonged contraction.
Diabetes
; 55(6): 1855-61, 2006 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-16731853
6.
The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.
Circ Res
; 93(3): e26-32, 2003 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-12869391
7.
Metabolic adaptations to repeated periods of contraction with reduced blood flow in canine skeletal muscle.
BMC Physiol
; 5: 11, 2005 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-16018808
8.
Genetic association of the CCR5 region with lipid levels in at-risk cardiovascular patients.
Circ Cardiovasc Genet
; 3(2): 162-8, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20130232
9.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
J Med Chem
; 53(6): 2656-60, 2010 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20196613
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