RESUMEN
PET/CT imaging is frequently used for cancer diagnosis and restaging as metabolically active cells, including cancer, utilize glucose for proliferation. F-FDG is the most commonly utilized radiopharmaceutical in PET/CT imaging. Limitations of F-FDG imaging include intense physiologic uptake in benign tissues such as the brain and myocardium. We present a case of non-small cell lung cancer with myocardial and pericardial metastases obscured by physiologic F-FDG cardiac uptake but detected with the investigational PET radiotracer (4S)-4-(3-F-fluoropropyl)-L-glutamate (F-FSPG), which targets a pathway associated with glutathione biosynthesis. This case demonstrates the added value of F-FSPG PET/CT imaging.
Asunto(s)
Glutamatos , Neoplasias Cardíacas/diagnóstico por imagen , Neoplasias Cardíacas/secundario , Tomografía Computarizada por Tomografía de Emisión de Positrones , Carcinoma de Pulmón de Células no Pequeñas/patología , Femenino , Glutamatos/metabolismo , Neoplasias Cardíacas/metabolismo , Humanos , Neoplasias Pulmonares/patología , Persona de Mediana EdadRESUMEN
INTRODUCTION: This review provides an overview of the current and potential clinical applications of sonoelastography, and describes the central principles that provide clinical applications. Areas covered: The clinical use of sonoelastography that is reviewed includes liver fibrosis, breast mass evaluation, thyroid nodule evaluation, detection and quantification of head/neck lymphedema. Other topics discussed include application for tendens, prostate, and salivary gland. A systematic literature search was done using PubMed database and the results were grouped according to the clinical applications. Expert commentary: This review highlights the clinical application of sonoelastography for breast, thyroid, and lymph nodes as well as the evaluation of lymphedema.
Asunto(s)
Ensayos Clínicos como Asunto , Diagnóstico por Imagen de Elasticidad/métodos , Enfermedad , Humanos , Especificidad de ÓrganosRESUMEN
The pathogenesis of groove pancreatitis involves progressive cystic degeneration of hamartomatous pancreas rests which lie within the duodenal wall. Hamartomatous pancreatic rests can occur in other locations, but when located within the pancreaticoduodenal groove can lead to a particular clinical presentation following the development of fibrotic and inflammatory tissue. Although this is not a disease of the pancreas itself, the pancreatic duct and biliary system is frequently secondarily involved in this regional process. Identification of this entity and its varied appearances as a distinct pathology is essential given the unique management issues of groove pancreatitis.