Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Más filtros

Banco de datos
Tipo de estudio
Tipo del documento
Asunto de la revista
País de afiliación
Intervalo de año de publicación
1.
Cereb Cortex ; 29(8): 3514-3526, 2019 07 22.
Artículo en Inglés | MEDLINE | ID: mdl-30272135

RESUMEN

Early social interactions shape the development of social behavior, although the critical periods or the underlying neurodevelopmental processes are not completely understood. Here, we studied the developmental changes in neural pathways underlying visual social engagement in the translational rhesus monkey model. Changes in functional connectivity (FC) along the ventral object and motion pathways and the dorsal attention/visuo-spatial pathways were studied longitudinally using resting-state functional MRI in infant rhesus monkeys, from birth through early weaning (3 months), given the socioemotional changes experienced during this period. Our results revealed that (1) maturation along the visual pathways proceeds in a caudo-rostral progression with primary visual areas (V1-V3) showing strong FC as early as 2 weeks of age, whereas higher-order visual and attentional areas (e.g., MT-AST, LIP-FEF) show weak FC; (2) functional changes were pathway-specific (e.g., robust FC increases detected in the most anterior aspect of the object pathway (TE-AMY), but FC remained weak in the other pathways (e.g., AST-AMY)); (3) FC matures similarly in both right and left hemispheres. Our findings suggest that visual pathways in infant macaques undergo selective remodeling during the first 3 months of life, likely regulated by early social interactions and supporting the transition to independence from the mother.


Asunto(s)
Atención , Encéfalo/diagnóstico por imagen , Plasticidad Neuronal , Conducta Social , Vías Visuales/diagnóstico por imagen , Amígdala del Cerebelo/diagnóstico por imagen , Amígdala del Cerebelo/crecimiento & desarrollo , Animales , Animales Recién Nacidos , Encéfalo/crecimiento & desarrollo , Lóbulo Frontal/diagnóstico por imagen , Lóbulo Frontal/crecimiento & desarrollo , Neuroimagen Funcional , Macaca mulatta , Imagen por Resonancia Magnética , Masculino , Vías Nerviosas , Corteza Prefrontal/diagnóstico por imagen , Corteza Prefrontal/crecimiento & desarrollo , Lóbulo Temporal/diagnóstico por imagen , Lóbulo Temporal/crecimiento & desarrollo , Corteza Visual/diagnóstico por imagen , Corteza Visual/crecimiento & desarrollo , Vías Visuales/crecimiento & desarrollo
2.
Psychopharmacology (Berl) ; 232(4): 745-54, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25138647

RESUMEN

RATIONALE: Cocaine addiction is characterized by alternating cycles of abstinence and relapse and loss of control of drug use despite severe negative life consequences associated with its abuse. OBJECTIVE: The objective of the present study was to elucidate critical neural circuits involved in individual vulnerabilities to resumption of cocaine self-administration following prolonged abstinence. METHODS: The subjects were three female rhesus monkeys in prolonged abstinence following a long history of cocaine self-administration. Initial experiments examined the effects of acute cocaine administration (0.3 mg/kg, IV) on functional brain connectivity across the whole brain and in specific brain networks related to behavioral control using functional magnetic resonance imaging in fully conscious subjects. Subsequently, these subjects were allowed to resume cocaine self-administration to determine whether loss of basal connectivity within specific brain networks predicted the magnitude of resumption of cocaine intake following prolonged abstinence. RESULTS: Acute cocaine administration robustly decreased global functional connectivity and selectively impaired top-down prefrontal circuits that control behavior, while sparing connectivity of striatal areas within limbic circuits. Importantly, impaired connectivity between prefrontal and striatal areas during abstinence predicted cocaine intake when these subjects were provided renewed access to cocaine. CONCLUSIONS: Based on these findings, loss of prefrontal to striatal functional connectivity may be a critical mechanism underlying the negative downward spiral of cycles of abstinence and relapse that characterizes cocaine addiction.


Asunto(s)
Cocaína/administración & dosificación , Cuerpo Estriado/efectos de los fármacos , Corteza Prefrontal/efectos de los fármacos , Animales , Trastornos Relacionados con Cocaína/fisiopatología , Cuerpo Estriado/patología , Femenino , Macaca mulatta , Imagen por Resonancia Magnética , Vías Nerviosas/efectos de los fármacos , Corteza Prefrontal/patología , Autoadministración , Factores Sexuales , Síndrome de Abstinencia a Sustancias/patología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA