1.
J Org Chem
; 75(4): 1251-8, 2010 Feb 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20088577
RESUMEN
A simple protocol for the synthesis of Weinreb benzamides and alpha,beta-unsaturated Weinreb amides through a palladium-catalyzed cross-coupling reaction between organoboronic acids and N-methoxy-N-methylcarbamoyl chloride has been developed. The method is also applicable to the use of potassium organotrifluoroborates.
Asunto(s)
Amidas/química , Ácidos Borónicos/química , Carbamatos/química , Alquenos/química , Catálisis , Ciclización , Espectroscopía de Resonancia Magnética , Estructura Molecular , Paladio , Estereoisomerismo , Relación Estructura-Actividad
2.
Bioorg Med Chem Lett
; 16(2): 307-10, 2006 Jan 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16275071
RESUMEN
Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.