RESUMEN
Agarsenone (1), a new cadinane sesquiterpenoid, was isolated from the resin of Commiphora erythraea. The structures of 1 and its decomposition products agarsenolides (2a and 2b) and myrrhone (3) were established by extensive NMR spectroscopic analysis. The absolute configuration of 3 and the relative and absolute configurations of 1 were assigned by comparison of experimental and calculated optical rotatory dispersion and electronic circular dichroism spectra.
Asunto(s)
Sesquiterpenos/aislamiento & purificación , Dicroismo Circular , Commiphora/química , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Dispersión Óptica Rotatoria , Sesquiterpenos Policíclicos , Resinas de Plantas/química , Sesquiterpenos/químicaRESUMEN
Boropinic acid is a natural isopentenyloxycinnamic acid extracted from the aerial parts of Boronia pinnata Sm. (Rutaceae) with soybean 5-lipoxygenase inhibitory activity. In this paper the topical anti-inflammatory activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds (15, 17, 19, 20) revealed an effect comparable (ID(50)=0.18÷0.72µmol/cm(2)) to that of the reference drug indomethacin (ID(50)=0.23µmol/cm(2)), a non-steroidal anti-inflammatory drug.
Asunto(s)
Antiinflamatorios/química , Antiinflamatorios/uso terapéutico , Ácidos Borónicos/química , Ácidos Borónicos/uso terapéutico , Rutaceae/química , Administración Tópica , Animales , Antiinflamatorios/administración & dosificación , Antiinflamatorios no Esteroideos/uso terapéutico , Ácidos Borónicos/administración & dosificación , Aceite de Crotón , Indometacina/uso terapéutico , Inflamación/inducido químicamente , Inflamación/tratamiento farmacológico , Masculino , RatonesRESUMEN
[reaction: see text] Ytterbium triflate was shown to be an effective catalyst in promoting the synthesis of either isopropyl esters or free alpha-hydroxy-arylacetic acids from substituted aromatic glyoxals and aryl methyl ketones, respectively. The reaction to provide acids starting from differently substituted ketones was carried out by an environmentally friendly method using an aqueous medium as a solvent and giving the adducts in 78-99% yield without any further purification after the usual workup.