Reduction by air purifier of particulate concentration during orthodontic procedures: a pilot study.

BACKGROUND: The SARS-CoV-2 pandemic has raised awareness of the importance of air quality. This pilot study arose from the need to reduce the concentration of particulate matter in the dental office during orthodontic procedures. To evaluate the efficacy of using an air purifier during orthodontic care in the dental office to reduce the concentration of ambient particulate matter. RESULTS: Significant reductions in particle numbers were obtained for all particle sizes except the largest particles counted (10 µm) through use of the air filter. A marked association between higher humidity levels and higher particle counts was also observed. CONCLUSIONS: Using an air purifier during dental care achieves a significant reduction in the concentration of ambient particles in the dental office. There is a correlation between higher relative humidity and higher particle concentration. The probability of obtaining a maximum particulate concentration level of 0.3 and 0.5 µm is 1000 times lower when using an air purifier.

Safety and Efficacy of a New Synthetic Material Based on Monetite, Silica Gel, PS-Wallastonite, and a Hydroxyapatite Calcium Deficient: A Randomized Comparative Clinic Trial.

Background and Objectives: Maxillary bone defects related to post-extraction alveolar ridge resorption are usual. These defects may lead to failure in further surgical implant phases given the lack of bone volume to perform the dental implant. The objective of this clinical assay was to evaluate the safety and efficacy of an experimental synthetic bone substitute in the preservation of post-extraction maxillary alveoli. Materials and Methods: 33 voluntary patients who had at least one maxillary premolar tooth that was a candidate for exodontia (n = 39) and subsequent implant rehabilitation participated. The regenerated alveoli were monitored by means of periodic clinical examinations (days 9 ± 1, 21 ± 4, 42 ± 6, and 84 ± 6), measuring the height and width of the alveolar crest (days 0 and 180 ± 5), measurement of radiodensity using tomographic techniques (days 0-5 and 175 ± 5), and histological examination of biopsies collected at 180 ± 5 days. Results: No significant differences were observed during the entire follow-up period between the two groups with respect to the safety variables studied. A variation in width of -0.9 ± 1.3 mm and -0.6 ± 1.5 mm, and a variation in height of -0.1 ± 0.9 mm and -0.3 ± 0.7 mm was observed for experimental material Sil-Oss® and Bio-Oss®, respectively. The radiodensity of the alveoli regenerated with the experimental material was significantly lower than that corresponding to Bio-Oss®. However, the histological study showed greater osteoid matrix and replacement of the material with newformed bone in the implanted beds with the experimental material. Conclusions: Both materials can be used safely and proved equally effective in maintaining alveolar flange dimensions, they are also histologically biocompatible, bioactive and osteoconductive. The experimental material showed the advantage of being resorbable and replaced with newformed bone, in addition to promoting bone regeneration.

Effect of virgin olive oil as spreadable preparation on atherosclerosis compared to dairy butter in Apoe-deficient mice.

Olive oil is the main source of lipid energy in the Mediterranean diet and there is strong evidence of its health benefits. The effect of extra virgin olive oil (EVOO) in the form of a preparation of spreadable virgin olive oil (S-VO) on the progression of atheroma plaques was investigated in Apoe-deficient mice, a model of accelerated atherosclerosis. METHODS: Two isocaloric Western purified diets containing 20% fat, either as S-VO or as dairy butter, were used to feed 28 males and 16 females of two-month-old Apoe-deficient mice for 12 weeks. S-VO was prepared by blending more than 75% virgin olive oil with other vegetal natural fat to obtain a solid fat. Plasma total cholesterol, triglycerides and HDL cholesterol were measured. Hepatic lipid droplets were analyzed. Areas of atherosclerotic aortic lesions were quantified in cross-sectional images of the proximal aorta and en face analysis of the whole aorta. RESULTS: Total plasma cholesterol was increased in mice on the butter-supplemented diet in both female and male mice compared to S-VO, and the ratio of TC/HDL-cholesterol was significantly lower in S-VO than in the butter diet, although only in males, and no differences in plasma triglycerides were observed. No significant differences in hepatic lipid droplets were observed between diets in either sex. Aortic lesion areas were significantly higher in mice consuming the butter versus the S-VO diet in both sexes. CONCLUSION: Extra virgin olive oil prepared in spreadable form maintained the delay in atheroma plaque progression compared to butter.

The Influence of Anxiety on Postoperative Quality of Life Regarding Implant Treatments: An Epidemiological Study.

Dental treatment anxiety is highly prevalent worldwide. This is particularly important in the field of implantology since, in daily clinical practice, it translates into an increase in the difficulty of treatments, extending surgical times and having repercussions in the postoperative period. The aim of this multicentre, cross-sectional, epidemiological study was to determine the influence of anxiety levels in the postoperative period of an implant treatment on patients treated at two dental departments in Extremadura (Spain). To analyse anxiety levels, the modified Corah's Dental Anxiety Scale questionnaire was administered before surgical treatment. To analyse the postoperative period, another questionnaire was provided 7 days after surgery. The study was conducted on a total of 102 patients (55 men and 47 women), with a mean age of 47.99 years. The results indicated that patients with a high and severe degree of anxiety had a poorer quality of life in general. Patients with a higher degree of anxiety perceived greater swelling at 24, 48, 72 h and one week after surgery.

Comparative Study of the Effectiveness of Vedolizumab Versus Ustekinumab After Anti-TNF Failure in Crohn's Disease (Versus-CD): Data from the ENEIDA Registry.

BACKGROUND: Both vedolizumab and ustekinumab are approved for the management of Crohn's disease [CD]. Data on which one would be the most beneficial option when anti-tumour necrosis factor [anti-TNF] agents fail are limited. AIMS: To compare the durability, effectiveness, and safety of vedolizumab and ustekinumab after anti-TNF failure or intolerance in CD. METHODS: CD patients from the ENEIDA registry who received vedolizumab or ustekinumab after anti-TNF failure or intolerance were included. Durability and effectiveness were evaluated in both the short and the long term. Effectiveness was defined according to the Harvey-Bradshaw index [HBI]. The safety profile was compared between the two treatments. The propensity score was calculated by the inverse probability weighting method to balance confounder factors. RESULTS: A total of 835 patients from 30 centres were included, 207 treated with vedolizumab and 628 with ustekinumab. Dose intensification was performed in 295 patients. Vedolizumab [vs ustekinumab] was associated with a higher risk of treatment discontinuation (hazard ratio [HR] 2.55, 95% confidence interval [CI]: 2.02-3.21), adjusted by corticosteroids at baseline [HR 1.27; 95% CI: 1.00-1.62], moderate-severe activity in HBI [HR 1.79; 95% CI: 1.20-2.48], and high levels of C-reactive protein at baseline [HR 1.06; 95% CI: 1.02-1.10]. The inverse probability weighting method confirmed these results. Clinical response, remission, and corticosteroid-free clinical remission were higher with ustekinumab than with vedolizumab. Both drugs had a low risk of adverse events with no differences between them. CONCLUSION: In CD patients who have failed anti-TNF agents, ustekinumab seems to be superior to vedolizumab in terms of durability and effectiveness in clinical practice. The safety profile is good and similar for both treatments.

Bioinspired Intelligence II.

Bioinspired intelligence methods are currently common approaches for both engineers and the scientists [...].

Piperacillin-Tazobactam as an Adjuvant in the Mechanical Treatment of Patients with Periodontitis: A Randomized Clinical Study.

In this study, the aim was to evaluate the effects of the adjuvant piperacillin-tazobactam solution in the mechanical treatment of periodontitis. A single-blind split-mouth randomized study, it included 24 participants. All of them presented periodontitis stage III according to the 2018 World Workshop classification and the presence of at least one of the following periodontal pathogens: Aggregatibacter actinomycetemcomitans; Porphyromona gingivalis; Treponema denticola; Tannerella forsythia; Prevotella intermedia. The study established two groups: a control group (SRP: scaling and root planing) and a test group (SRP plus local piperacillin-tazobactam). The final recruitment included 11 women (45.8%) and 13 men (54.2%). The age range was between 25 and 72 years, and the mean age was 57 ± 10.20 years. Clinical controls were performed at 2 weeks, 3 months, and 6 months, repeating the SRP and applying the piperacillin-tazobactam solution again at the 3-month appointment. The clinical attachment level decreased by a mean of 2.13 ± 0.17 mm from the baseline to 6 months in the test group versus 1.63 ± 0.18 mm in the control group. The mean probing pocket depth decreased from 1.32 ± 0.09 mm in the test group, versus from 0.96 ± 0.14 mm on the control side. The plaque index in the test group decreased by 0.46 ± 0.04, while it decreased by an average of 0.31 ± 0.04 in the control group. In conclusion, the local use of piperacillin-tazobactam as complementary therapy produces better clinical results in patients with periodontitis. However, these results are not maintained over time, and so a more persistent local application is necessary.

Influence of Serum Vitamin D Levels on Survival Rate and Marginal Bone Loss in Dental Implants: A Systematic Review.

This systematic literature review set out to investigate the relationship between serum vitamin D levels and dental implants in terms of survival rates, marginal bone loss, and associated complications. The review was conducted according to PRISMA guidelines, performing an electronic search in four databases (Pubmed, Web of Science, Cochrane, and Scopus), complemented by a manual search up to April 2022. Four articles were selected for analysis. The Newcastle-Ottawa Quality Assessment Scale tool was used to assess the quality of evidence of cohort studies, and the Cochrane bias assessment tool was used to assess the quality of evidence of randomized clinical trials. The study included 1089 patients restored with 1984 dental implants, with follow-up periods ranging from 20-240 months. Cases presenting lower serum vitamin D levels obtained slightly worse results in terms of marginal bone loss. Longer follow-up periods are needed in order to determine whether serum vitamin D levels affect implant survival rates and osseointegration over time.

Dental Transmigration: An Observational Retrospective Study OF52 Mandibular Canines.

The aim of this study was to analyze the prevalence of transmigrated canines in a Spanish population by evaluating their clinical and radiological characteristics. The descriptive observational study obtained 6840 orthopantomographs from all patients seeking dental care in the years 2017-21 via the Patient Reception Service and Dentistry Service at the Faculty of Dentistry at the Complutense University of Madrid and the Central Hospital of the Red Cross of Madrid (Spain). In total, 52 patients presented transmigrated canines, establishing a prevalence of 0.76%. This sample comprised 28 women and 24 men. Whenever a transmigrated canine was identified, a CBCT scan was obtained and used to evaluate the clinical and radiological variables associated with canine transmigration. The predominant side of the transmigration was the left (57.69%) compared to the right side (42.30%). The position of the canine, in order of frequency, according to the Mupparapu classification, corresponded to type IV (42.30%), type II (36.53%), type I (15.38%), and type V (5.76%), with no type III transmigrations found. Clinical manifestations were only recorded in 17.30% of cases, and 11.53% of the radiological findings showed the presence of tooth cysts that were confirmed by histopathological studies. Other impactions, in addition to the transmigrated canine, were found in five patients (9.61%), with the majority being the presence of third molars.

Clinical Evaluation of Dental Implants with a Double Acid-Etched Surface Treatment: A Cohort Observational Study with Up to 10-Year Follow-Up.

BACKGROUND AND OBJECTIVES: The main purpose of this study was to evaluate the survival and success rates of dental implants with a double acid-etched surface treatment with evaluation times up to 10 years post-loading. Materials and Methods: This study was conducted at a hospital oral surgery and implantology unit. It included 111 dental implants with a double acid-etched surface. Three groups were created: Group 1 (1-3 years loading), Group 2 (3-5 years loading), and Group 3 (over 5 years loading). Probing depth, resonance frequency analysis (ISQ value), and marginal bone loss were evaluated. Results: The data obtained underwent statistical analysis. Overall, 78 patients were included in the study, who received, in total, 111 dental implants, all replacing single teeth. Mean probing depth was 3.03 mm and mean ISQ was 65.54. Regarding marginal bone loss, in Group 1, 67.6% of implants did not undergo any thread loss, in Group 2, 48.3%, and in Group 3, 59.6%; 59.10% of all implants did not present thread loss with a mean bone loss of 0.552 mm. The implant survival rate was 99.1%, and the success rate was 96.37%. Conclusions: Implants with a double acid-etched surface showed excellent success rates in terms of marginal bone loss, ISQ, and probing depth after up to 10 years of loading, making them a clinically predictable treatment option. Future studies are needed to compare this implant surface with other types in different restorative situations.

Meta-analysis of the etiology of odontogenic maxillary sinusitis.

OBJECTIVE: To identify and evaluate the frequency of the different odontogenic conditions that may lead to maxillary sinusitis. STUDY DESIGN: An observational and retrospective meta-analysis was carried out on 770 cases of maxillary sinusitis obtained from a literature review of 15 articles. RESULTS: Maxillary sinusitis most commonly manifests itself as chronic maxillary sinusitis. It is more common in females and is most often diagnosed in the fifth decade of life. The teeth most predominantly affected are the molars, with the first molar tooth being the most frequently involved. The principal etiological factor is extraction.

Epidemiological Features and Clinical Repercussions of Supernumerary Teeth in a Multicenter Study: A Review of 518 Patients with Hyperdontia in Spanish Population.

OBJECTIVES: The aim of this study was to establish the prevalence of supernumerary teeth (ST) in a sector of the population of Madrid, as well as possible complications associated with the presence of these teeth. MATERIALS AND METHODS: The study investigated patients (n = 28,114) who sought dental care at the Oral Surgery Service of three different centers between May 2005 and April 2018. Cases that did not present this numeric dental developmental variation were discarded, registering only those presenting ST. STATISTICAL ANALYSIS: Statistical analysis consisted of univariate analysis (mean, standard deviation, median, etc.), bivariate analysis applying the chi-squared test, whereby statistical significance was established with a confidence interval (CI) of 95% (p < 0.05), and multivariate analysis by means of classification and decision trees. RESULTS: The study found ST in 518 patients, representing a prevalence of 1.84%. The 518 patients presented a total of 726 ST. Distomolars were the most common, representing 37.7% of the sample, followed by premolars (20.1%). About 70.5% of the sample were located in the maxilla and 78% of ST were impacted. Radiographs revealed that 39.7% of STs were associated with disorders. Supplementary morphology appeared in 52.1% of the sample. CONCLUSIONS: Although mesiodens is considered the most common ST, the present study found distomolars and supernumerary premolars to be the most frequently occurring. Pathology was associated with 39.7% of the ST sample. Early diagnosis allows optimal patient management and treatment planning, with intervention at an appropriate time to prevent complications in development and so reduce later treatment need.

Placing Dental Implants through Impacted Teeth to Support a Fixed Partial Denture in a Geriatric Patient as an Alternative to Invasive Extraction Surgeries.

Multiple dental impactions not associated with craniofacial syndromes are a rare condition and present the dentist with a therapeutic challenge when it comes to performing surgical/restorative treatments in adult patients. This case report describes a geriatric patient with multiple impacted teeth restored by means of two different protocols. In the second quadrant, an impacted tooth was extracted followed by regeneration and placement of an implant. In the third quadrant, implants were placed though impacted teeth for restoration with a fixed partial prosthesis. Placing dental implants through impacted teeth may offer a possible therapeutic option for implant-supported restorations in middle-aged or elderly patients, for whom surgery and orthodontic traction are not possible, and/or patients who refuse to undergo more invasive extraction surgery.

2018 IEEE International Work Conference on Bioinspired Intelligence (IWOBI): Conference Report.

The International Work Conference on Bioinspired Intelligence (IWOBI) is an annual event that comprises both an international peer-reviewed scientific conference and a set of workshops and other activities in order to foster the research abilities and expertise of young researchers in the field of bioinspired intelligence. IWOBI 2018 has been characterized by a strong transdisciplinary component. The main conference themes were at the intersection between classical engineering disciplines and computer science, and the life and health sciences. This was motivated by the scientific environment that defines research that is being conducted in Costa Rica. Even though IWOBI is an international event, it was very important for the local organizing committee to focus on knowledge areas that were considered of special interest to Costa Rican researchers and to students looking to start their scientific careers. With such great expectations, IWOBI 2018 has been the first IWOBI conference in history to have parallel tracks. In addition to a regular track, a biocomputation and related techniques track was developed, as well as another one devoted to high-performance computing (HPC) systems applications for life and health sciences applications. Workshops were another important resource developed within IWOBI 2018. They were considered a very important tool in order to foster and train young researchers within the country and they are a very valuable chance to establish direct networking with elite researchers from different countries and research interests. IWOBI 2018 was the first IWOBI conference that implemented real and effective workshops. There were two workshops, one of them devoted to COPASI software and the other one focused on the use of the message passing interface (MPI) parallel programming library.

Application of the Social Appeal Scale to a Selected Spanish Population.

PURPOSE: The aim of this study was to validate the Social Appeal Scale (SAS) among the Spanish general population, exploring the underlying dimensions of the construct assessed. MATERIALS AND METHODS: The SAS test was applied to 555 participants between 16 and 75 years of age. The scale is divided into four dimensions: social competence (SC), intellectual ability (IA), psychologic adjustment (PA), and relationship satisfaction (RS). RESULTS: The SAS (12 items) had a Cronbach alpha of .93, and SC had a Cronbach alpha of .83. For IA it was .85, for PA .87, and for RS .84. CONCLUSION: Bearing in mind the limitations of the present study, it may be concluded that the Social Appeal Scale is a valid and reliable instrument to assess social perceptions related to changes in tooth color.

Adherencia al tratamiento y nivel de control en pacientes asmáticos en un hospital de Lima

Objetivo: Describir la asociación entre el control del asma y la adherencia al tratamiento en los pacientes del Hospital Nacional Dos de Mayo en los años 2019-2020. Materiales y métodos: Se realizó un estudio cuantitativo, descriptivo y retrospectivo, de tipo clínico, durante el periodo 2019-2020, en pacientes asmáticos del Hospital Nacional Dos de Mayo (HNDM) para evaluar la relación entre control del asma y adherencia al tratamiento en los pacientes atendidos en el Consultorio de Asma del Servicio de Neumología. La información fue recolectada de las historias clínicas y los datos registrados fueron los siguientes: test de adherencia a los inhaladores (TAI), test de control de asma (ACT), edad, sexo, tratamiento instaurado, tiempo de enfermedad y la valoración nutricional, a través de la revisión de historias clínicas. El análisis estadístico se realizó con el software IBM SPSS Statistics versión 22, y para determinar la asociación se realizó la prueba estadística X2. Resultados: Se evaluaron 187 pacientes mediante historias clínicas, 84 hombres (44,92 %) y 103 mujeres (55,08 %). El promedio de edad fue de 59,42 ± 15,08 años (solo los mayores de edad fueron considerados en el estudio). Mediante el análisis de los datos de las historias clínicas, se determinó que había 86 pacientes controlados (45,99 %) y que 48 pacientes eran adherentes (25,67 %). El corticoide inhalado (CSI) fue el tratamiento más usado (50,80 %). El tipo inconsciente fue la modalidad más frecuente de paciente incumplidor (64,17 %). El promedio de tiempo de enfermedad, en años, estuvo en 21,78 ± 16,75. Conclusiones: El 75% de los pacientes asmáticos con adherencia al tratamiento controlan la enfermedad.

Objective: To describe the association between asthma control and adherence to treatment among patients of the Hospital Nacional Dos de Mayo from 2019 to 2020. Materials and methods: A quantitative, descriptive and retrospective clinical study was carried out in asthma patients treated at the asthma office of the Pneumology Service from the Hospital Nacional Dos de Mayo (HNDM) from 2019 to 2020 to assess the relationship between asthma control and adherence to treatment. The following data was collected from the medical records: test of adherence to inhalers (TAI) results, asthma control test (ACT) results, age, sex, treatment, disease period and nutritional assessment. The statistical analysis was performed using IBM SPSS Statistics statistical software version 22 and the association between both variables was determined by the chi-square test. Results: One hundred eighty-seven (187) patients were evaluated through their medical records, out of which 84 were men (44.92 %) and 103 were women (55.08 %). The mean age was 59.42 ± 15.08 years (only adults participated in the study). Data from the medical records determined that 86 patients (45.99 %) had their asthma under control and 48 showed adherence to treatment (25.67 %). Inhaled corticosteroid (ICS) was the most widely used treatment (50.80 %). Irresponsible people were the most frequent noncompliant patients (64.17 %). The mean disease period was 21.78 ± 16.75. Conclusions: Seventy-five percent (75 %) of asthma patients who adhere to treatment are able to control their condition.

[Telematic consultations by nursing staff for patients with inflammatory bowel disease: evaluation of its capacity for resolving problems and its costs]. / Consulta telemática realizada por Enfermería en pacientes con enfermedad inflamatoria intestinal: valoración de su capacidad resolutiva y costes.

INTRODUCTION: The management of patients with inflammatory bowel disease (IBD) is associated with a significant use of healthcare resources. In 2009, a digestive diseases nursing consultation, with availability of health telematic media was created in our hospital (CHUVI). The important activity performed in this area encouraged us to quantify the cost savings for the care health system. AIMS: 1) To evaluate the results of the implementation of a telematic IBD consultation. 2) To assess the capacity for resolving problems by nurses. 3) To estimate the potential cost savings of telematic nursing consultation in IBD. MATERIAL AND METHOD: We collected data on telematic activity from 2009 to 2011. The estimated cost saving was calculated by applying the fees for health services published by our National Health Service (SERGAS) for care in new outbreaks of IBD activity. Data were analyzed with SPSS 15.0 RESULTS: There was a significant linear increase on the resolution of telephone demands by nurses (P=.03) and an important decrease of demands needing medical advice (P<.0001). Focusing on IBD outbreak claims (n=452), only 65 patients (14.38%) required medical attention in emergency services, and 33 (7.3%) were hospitalized. Altogether we calculated an average cost saving since 2009 to 2011 of 73,603€. CONCLUSIONS: We found a gradual increase in resolving telematic care demands by nurses. Telematic consultation can lead to significant cost savings, which justify the implementation of a digestive diseases nurse consultation.

Desplazamiento accidental del tercer molar al seno maxilar: protocolo de actuación / Accidental displacement of the third molar into the maxillary sinus: action protoco

Introducción: El desplazamiento accidental del tercer molar hacia el seno maxilar es una complicación de la cirugía bucal. La extracción de estos dientes generalmente es compleja debido a la escasa visibilidad, el espacio limitado y la ubicación espacial del diente, por lo que se requiere tener un cuidado meticuloso durante el tratamiento. Objetivo: El objetivo de este artículo ha sido el de establecer un protocolo de actuación basado tanto en el tratamiento quirúrgico como farmacológico, y el seguimiento que este tipo de complicaciones necesita según la literatura. Caso clínico: Se presenta el caso clínico de un varón de 17 años de edad, sin antecedentes médicos de interés, que fue remitido por su odontólogo para proceder a la valoración y extracción quirúrgica del tercer molar superior izquierdo que había sido desplazado al interior del seno maxilar tras el intento de exodoncia, y que producía sintomatología compatible con sinusitis aguda. La exploración radiológica descartó la afectación del resto de senos paranasales y confirmó la obstrucción casi completa del seno maxilar izquierdo. La extracción del cordal se realizó mediante ostectomía de la pared anterior del seno, pautándose tratamiento farmacológico postoperatorio y controles periódicos durante el primer año. Discusión: La terapéutica recomendada para esta complicación incluye la recuperación inmediata del diente, o la extracción posterior mientras la fibrosis se desarrolla en torno al diente desplazado, según sea necesario, tomando en cuenta la infección, el rango limitado del movimiento de la mandíbula, o malestar psicológico del paciente. El tratamiento médico y farmacológico que debe prescribirse según la literatura revisada, para facilitar el drenaje sinusal y el control de la infección. Conclusión: Para evitar este tipo de complicaciones, conviene realizar un estudio radiológico completo en los casos de cercanía del tercer molar superior en las inmediaciones del seno maxilar, y valorar la disposición e inclinación del mismo

Introduction: Accidental displacement of the third molar into the maxillary sinus is one of the complications of oral surgery. These extractions are usually complex due to some factors such as low visibility, limited space and the location of the tooth; so special care on these treatments is required. Objective: To establish an action protocol based on a surgical as well as a pharmacological treatment, and the monitoring that this kind of complications need according to the literature. Clinical case: A 17-year old man, with a noncontributory medical history, was referred to our clinic by a colleague to evaluate and perform a surgical extraction of his upper left third molar, which had been displaced into the maxillary sinus after a failed extraction, and was generating symptoms of acute sinusitis. The radiographic examination dismissed the affectation of the rest of the paranasal sinuses and confirmed the almost totally blockage of the left maxillary sinus. The extraction of this third molar took place by means of an anterior-wall ostectomy of the sinus; afterwards a pharmacological treatment was prescribed and regular control visits along the first year were planned. Discusion:The suggested treatment for this kind of complications involves the immediate recuperation of the tooth or its later extraction meanwhile the fibrosis forms around the displaced tooth, as needed. We have to take into account the infection, the limited mandibular range of movement as well as the patient's psychological discomfort. The medical and pharmacological treatment should be prescribed following the reviewed literature, in order to obtain the sinusal drainage and the infection control. Conclusion: It is convenient to carry out an exhaustive radiological examination in case of close relation between the maxillary third molar and the maxillary sinus as well as evaluate its position and inclination to avoid this kind of complications

A jerte valley cherry-based product as a supply of tryptophan.

L-Tryptophan (tryptophan) is an essential amino acid in humans. It has important roles as a precursor of different bioactive compounds. Based on previous studies in which tryptophan has been shown to be present in fresh cherries, the aim of the present work was to analyze the tryptophan content of a Jerte Valley cherry-based product. A previously optimized method of analysis of tryptophan was used, ie, high-performance liquid chromatography with fluorescence detection (HPLC/FL). As expected, HPLC/FL technique permitted to detect and quantify the tryptophan content in a different matrix rather than fresh cherries. In fact, the Jerte Valley cherry-based product contained 69.54 ± 10.64 ppm of tryptophan, thereby showing that this product is a good source of tryptophan. In summary, it has been proven that the Jerte Valley cherry-based product is rich in tryptophan and may be indicated as a supply of this essential amino acid as well as having potential health benefits for conditions where tryptophan is necessary.