RESUMEN
We associated Laguna Negra virus with hantavirus pulmonary syndrome in Mato Grosso State, Brazil, and a previously unidentified potential host, the Calomys callidus rodent. Genetic testing revealed homologous sequencing in specimens from 20 humans and 8 mice. Further epidemiologic studies may lead to control of HPS in Mato Grosso State.
Asunto(s)
Síndrome Pulmonar por Hantavirus/veterinaria , Orthohantavirus/genética , Enfermedades de los Roedores/virología , Animales , Arvicolinae , Teorema de Bayes , Brasil/epidemiología , Variación Genética , Orthohantavirus/clasificación , Síndrome Pulmonar por Hantavirus/epidemiología , Síndrome Pulmonar por Hantavirus/virología , Humanos , Funciones de Verosimilitud , Ratones , Tipificación de Secuencias Multilocus , Proteínas de la Nucleocápside/genética , Filogenia , Enfermedades de los Roedores/epidemiologíaRESUMEN
To study the dynamics of wild rodent populations and identify potential hosts for hantavirus, we conducted an eco-epidemiologic study in Campo Novo do Parecis, Mato Grosso State, Brazil. We detected and genetically characterized Castelo dos Sonhos virus found in a species of pygmy rice rat (Oligoryzomys utiaritensis).
Asunto(s)
Reservorios de Enfermedades/veterinaria , Infecciones por Hantavirus/veterinaria , Orthohantavirus/genética , Enfermedades de los Roedores/epidemiología , Sigmodontinae/virología , Animales , Anticuerpos Antivirales/sangre , Brasil/epidemiología , ADN Viral/análisis , Reservorios de Enfermedades/virología , Orthohantavirus/inmunología , Orthohantavirus/aislamiento & purificación , Infecciones por Hantavirus/epidemiología , Infecciones por Hantavirus/virología , Filogenia , Enfermedades de los Roedores/virología , Análisis de Secuencia de ADNRESUMEN
We describe evidence of circulation of hantaviruses in the influence area of the Santarém-Cuiabá Highway (BR-163) in the Brazilian Amazon through the prevalence of specific antibodies against hantaviruses in inhabitants living in four municipalities of this area: Novo Progresso (2.16%) and Trairão (4.37%), in state of Pará (PA), and Gua-rantã do Norte (4.74%) and Marcelândia (9.43%), in state of Mato Grosso. We also demonstrate the ongoing association between Castelo dos Sonhos virus (CASV) and hantavirus pulmonary syndrome (HPS) cases in the Castelo dos Sonhos district (municipality of Altamira, PA) and the first report of CASV in the municipalities of Novo Progresso and Guarantã do Norte. The results of this work highlight the risk for a possible increase in the number of HPS cases and the emergence of new hantavirus lineages associated with deforestation in this Amazonian area after the conclusion of paving works on BR-163 Highway.
Asunto(s)
Anticuerpos Antivirales/sangre , Infecciones por Hantavirus/virología , Orthohantavirus/aislamiento & purificación , ARN Viral/genética , Adolescente , Adulto , Anciano , Brasil , Niño , Preescolar , Femenino , Orthohantavirus/clasificación , Orthohantavirus/genética , Infecciones por Hantavirus/diagnóstico , Infecciones por Hantavirus/epidemiología , Síndrome Pulmonar por Hantavirus/virología , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Filogenia , Reacción en Cadena de la Polimerasa , Estaciones del Año , Estudios Seroepidemiológicos , Adulto JovenRESUMEN
We describe evidence of circulation of hantaviruses in the influence area of the Santarém-Cuiabá Highway (BR-163) in the Brazilian Amazon through the prevalence of specific antibodies against hantaviruses in inhabitants living in four municipalities of this area: Novo Progresso (2.16 percent) and Trairão (4.37 percent), in state of Pará (PA), and Gua-rantã do Norte (4.74 percent) and Marcelândia (9.43 percent), in state of Mato Grosso. We also demonstrate the ongoing association between Castelo dos Sonhos virus (CASV) and hantavirus pulmonary syndrome (HPS) cases in the Castelo dos Sonhos district (municipality of Altamira, PA) and the first report of CASV in the municipalities of Novo Progresso and Guarantã do Norte. The results of this work highlight the risk for a possible increase in the number of HPS cases and the emergence of new hantavirus lineages associated with deforestation in this Amazonian area after the conclusion of paving works on BR-163 Highway.