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1.
Targeting DYRK1A/B kinases to modulate p21-cyclin D1-p27 signalling and induce anti-tumour activity in a model of human glioblastoma.
J Cell Mol Med
; 25(22): 10650-10662, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34708541
2.
Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells.
Mol Cancer
; 13: 147, 2014 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24913641
3.
γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments.
BMC Cancer
; 14: 483, 2014 Jul 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-24996846
4.
Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.
BMC Cancer
; 14: 570, 2014 Aug 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-25104095
5.
The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells.
Sci Rep
; 13(1): 18237, 2023 10 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37880240
6.
Chk1 inhibitor-induced DNA damage increases BFL1 and decreases BIM but does not protect human cancer cell lines from Chk1 inhibitor-induced apoptosis.
Am J Cancer Res
; 12(5): 2293-2309, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35693081
7.
Chk1 inhibition induces a DNA damage bystander effect in cocultured tumour cells.
DNA Repair (Amst)
; 101: 103099, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33740539
8.
Checkpoint Kinase 1 (Chk1) inhibition fails to activate the Stimulator of Interferon Genes (STING) innate immune signalling in a human coculture cancer system.
Mol Biomed
; 2(1): 19, 2021 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35006469
9.
Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells.
FEBS J
; 288(15): 4507-4540, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33529438
10.
Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors.
J Med Chem
; 64(10): 6745-6764, 2021 05 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33975430
11.
Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B.
J Med Chem
; 64(13): 8971-8991, 2021 07 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34143631
12.
A high content, high throughput cellular thermal stability assay for measuring drug-target engagement in living cells.
PLoS One
; 13(4): e0195050, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29617433
13.
Cell Density Affects the Detection of Chk1 Target Engagement by the Selective Inhibitor V158411.
SLAS Discov
; 23(2): 144-153, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29048945
14.
Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage.
Sci Rep
; 7: 40778, 2017 01 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28106079
15.
Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.
J Med Chem
; 60(6): 2271-2286, 2017 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28199108
16.
Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy.
Cancer Lett
; 383(1): 41-52, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27693461
17.
Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity.
Sci Rep
; 6: 35874, 2016 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-27775084
18.
Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.
Oncotarget
; 7(51): 85033-85048, 2016 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-27829224
19.
mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition.
Mol Oncol
; 10(1): 101-12, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26471831
20.
Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC.
PLoS One
; 10(7): e0134306, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26218638