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The aim of this review is to provide an overview of the present association between Intermittent Fasting (IF), the Gut Microbiota (GM), and the adipocyte with respect to Metabolic Health (MH). A search was carried out through Dialnet, Scielo, Web of Science, Redalyc and PubMed, using keywords such as: "intermittent fasting", "time-restricted feeding", "gut microbiota" and "Metabolic Health". Intermittent fasting (IF) regimens promote weight loss, therefore contributing to improved metabolic health. IF beneficially participates in the modulation of the intestinal microbiome, allowing a continuous interaction with nutrients to be digested and shaping the intestinal immune responses during the development of cardiovascular disease, blood pressure and diabetes mellitus through metabolic activities.
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Microbioma Gastrointestinal , Adipocitos , Ayuno , Microbioma Gastrointestinal/fisiología , Humanos , IntestinosRESUMEN
Severe congenital eye malformations, particularly microphthalmia and anophthalmia, are one of the main causes of visual handicap worldwide. They can arise from multifactorial, chromosomal, or monogenic factors and can be associated with extensive clinical variability. Genetic analysis of individuals with these defects has allowed the recognition of dozens of genes whose mutations lead to disruption of normal ocular embryonic development. Recent application of next generation sequencing (NGS) techniques for genetic screening of patients with congenital eye defects has greatly improved the recognition of monogenic cases. In this study, we applied clinical exome NGS to a group of 14 Mexican patients (including 7 familial and 7 sporadic cases) with microphthalmia and/or anophthalmia. Causal or likely causal pathogenic variants were demonstrated in ~60% (8 out of 14 patients) individuals. Seven out of 8 different identified mutations occurred in well-known microphthalmia/anophthalmia genes (OTX2, VSX2, MFRP, VSX1) or in genes associated with syndromes that include ocular defects (CHD7, COL4A1) (including two instances of CHD7 pathogenic variants). A single pathogenic variant was identified in PIEZO2, a gene that was not previously associated with isolated ocular defects. NGS efficiently identified the genetic etiology of microphthalmia/anophthalmia in ~60% of cases included in this cohort, the first from Mexican origin analyzed to date. The molecular defects identified through clinical exome sequencing in this study expands the phenotypic spectra of CHD7-associated disorders and implicate PIEZO2 as a candidate gene for major eye developmental defects.
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Anoftalmos , Variación Genética , Secuenciación de Nucleótidos de Alto Rendimiento , Canales Iónicos/genética , Microftalmía , Fenotipo , Adolescente , Adulto , Anoftalmos/genética , Anoftalmos/patología , Niño , Femenino , Humanos , Lactante , Masculino , México , Microftalmía/genética , Microftalmía/patologíaRESUMEN
Congenital eye malformations are the second most common cause of childhood blindness and are originated by disruption of the normal process of eye development during embryonic stage. Their etiology is variable, although monogenic causes are of great importance as they have a high risk of familial recurrence. Included among the most severe congenital eye abnormalities are microphthalmia, defined by an abnormally small eye, and anophthalmia, characterized by congenital absence of ocular structures. The currrent knowledge of the genes involved in human microphthalmia and anophthalmia in humans is revised in this work.
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Anoftalmos/genética , Microftalmía/genética , Niño , Anomalías del Ojo/genética , Regulación del Desarrollo de la Expresión Génica , HumanosRESUMEN
The purpose of this study was to evaluate the effect of the consumption of seed oils from Vitis vinifera and Arachis hypogaea in platelet aggregation. The initial hypothesis suggested that subjects who have consumed these seed oils undergo modified platelet aggregation. This study was performed using a pre-post test design, with a control group, and double blind. The effects of the consumption of grape seed and peanut oils were measured for platelet aggregation in clinical and laboratory tests in 30 healthy subjects. In addition to this group, a control group of 4 health subjects received no treatment with oils, just 500 mg oral administration acetylsalicylic acid for 7 days. Platelet aggregation was assessed by the Born turbidimetric method, using 3 different concentrations of adenosine diphosphate as agonists (2, 54; 1, 17; and 0, 58 µM). The study subjects had very similar results; both oils were shown to have a significant reduction in platelet aggregation. Grape seed oil showed a decrease of 8.4 ± 1% in aggregation, compared with peanut oil, which decreased aggregation by 10.4 ± 1%. The control group, taking 500 mg OD aspirin for 7 days, showed a significant decrease in platelet aggregation, similar to that of oil ingestion. Each of the oils was analyzed for fatty acids, to determine which particular acids were presents in greater levels, which could explain the reduction in platelet aggregation. The oil found to be most abundant in grape seeds was linoleic acid (omega-6), and in peanuts, it was oleic acid (omega-9). However, in fact, both acids reduced platelet aggregation. Consumption of plant oils from grape seeds and peanuts had a lowering effect on platelet aggregation, in addition to containing a high content of unsaturated fatty acids. However, omega-3, omega-6, and omega-9 fatty acids were not specifically responsible for the reductions mentioned above.
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Ácidos Linoleicos/farmacología , Ácido Oléico/farmacología , Inhibidores de Agregación Plaquetaria/farmacología , Agregación Plaquetaria/efectos de los fármacos , Adolescente , Adulto , Arachis/química , Aspirina/farmacología , Método Doble Ciego , Ácidos Grasos/aislamiento & purificación , Ácidos Grasos/farmacología , Femenino , Humanos , Ácidos Linoleicos/aislamiento & purificación , Masculino , Nefelometría y Turbidimetría , Ácido Oléico/aislamiento & purificación , Aceites de Plantas/farmacología , Inhibidores de Agregación Plaquetaria/aislamiento & purificación , Semillas , Vitis/química , Adulto JovenRESUMEN
In February 2020, Coffea arabica L. grown on the coast and in the Southern Sierra Madre of the state of Oaxaca, Mexico obtained the denomination of origin. Which does not have data on color and chemical composition, the first associated with the degree of roasting and the second with lipids (17-18%), as the group of compounds responsible, in part, for flavor, consistency, and may contribute to health benefits. In the present work, color was determined on the CIE L*a*b* scale and the unsaturated fatty acids by Nuclear Magnetic Resonance (NMR) of 1H and 13C in samples of medium roasted specialty coffee from the "Pluma" coffee-growing region, Oaxaca, Mexico. The average value of L* luminosity in ground coffee was 42.1 ± 0.1 reported for a light roast. Unsaturated fatty acids were quantified from the lipid fraction of the gr1 ound grain by NMR 1H and 13C, obtaining on average the highest abundance of linoleic (41.7 ± 0.5 by 1 H and 41.24 ± 0.5 by 13C), followed by oleic (9.2 ± 0.2 by 1H and 7.4 ± 0.2 by 13C) and linolenic (1.5 ± 0.1 by H and 1.1 ± 0.2 by 13C). This study indicates that 1H and 13C NMR spectroscopy is a useful tool for the quantification of linolenic, linoleic, and oleic fatty acids by the method of key signal shifts of these acids found in lipid samples in roasted coffee grains.
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Coffea , Coffea/química , Café/química , México , Semillas/química , Ácidos Grasos Insaturados/análisisRESUMEN
The objective is the systematic review of studies published in Scielo, Redalyc, Dialnet, Web of Science, Scopus and Pubmed, related to the inclusion of fatty acids and lipid derivatives in the daily diet to prevent or delay the appearance or progression of Age-Related Macular Degeneration (AMD). The analysis of the research results consulted shows that AMD is one of the most frequent causes of blindness in subjects over 55 years of age. AMD is characterized by decreased vision, metamorphopsia, macropsies, micropsies, and central scotoma. Disease that must be diagnosed early as it can lead to irreversible blindness. Among the components of the diet that in numerous epidemiological studies have shown an association in the treatment of AMD and that are reviewed in this work are fatty acids, vitamins and carotenoids. There is ample evidence that fatty acids and lipid derivatives can be included in the diet plans of subjects with AMD.
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Carotenoides/administración & dosificación , Suplementos Dietéticos , Ácidos Grasos Omega-3/administración & dosificación , Degeneración Macular/dietoterapia , Degeneración Macular/prevención & control , Terapia Nutricional , Sustancias Protectoras/administración & dosificación , Vitaminas/administración & dosificación , Progresión de la Enfermedad , Ácidos Grasos/efectos adversos , Humanos , Luteína/administración & dosificación , Degeneración Macular/etiología , Conducta Sedentaria , Fumar/efectos adversosRESUMEN
To present a systematic review of published studies in databases such as PUBMED, REDALYC, SCIELO, DIALNET, SCOPUS, EBSCO and CONRICYT related to the role-played by the components present in the vegetable oil of grape seed (Vitis vinífera) and the prevention or delay in the onset or progression of neurodegenerative diseases. The analysis of the research revealed that neurodegenerative diseases causes alterations in consciousness or in the nervous system leading to severe damage in neuronal cells, these pathologies are considered gradual and progressive. Various syndromes manifest the degenerative diseases of the nervous system; in some of them the predominant symptom is the progressive dementia. Among the components of the diet that in numerous epidemiological studies have shown an inverse association are vitamins, minerals, carotenoids, polyunsaturated fatty acids and polyphenols, the latter being the ones addressed in this document. There is an important evidence that a nutritional support based on polyunsaturated fatty acids and antioxidants can be applied to subjects with a history of neurodegenerative conditions in order to act as neuroprotectors. This requires the determination of the nutritional benefits of these nutrients or of nutraceuticals for the health of this group of patients.
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Extracto de Semillas de Uva/administración & dosificación , Enfermedades Neurodegenerativas/prevención & control , Aceites de Plantas/administración & dosificación , Vitis/química , Animales , Antioxidantes , Terapias Complementarias , Ácidos Grasos Insaturados , Extracto de Semillas de Uva/química , Humanos , Fármacos Neuroprotectores , Aceites de Plantas/química , RatasRESUMEN
INTRODUCTION: the amount of fiber ingested in Latin American countries is lower (10-20 g/d) than recommended (35 g/d). An increase isrecommended for patients with metabolic syndrome (MS) to reduce cardiovascular risk, as well as to prevent obesity and other complications. OBJECTIVE: to evaluate whether increased dietary fiber consumption complements MS treatment and improves clinical and laboratory parameters in subjects at the San Martín Mexicapam "La Joya" Health Center, Oaxaca (Mexico). METHODS: an analytical-longitudinal study was carried out from January to April 2017, to evaluate nutritional status before and after intervention with dietary fiber and to measure cholesterol levels, triglycerides and fasting blood glucose. An increase of 15 g of fiber (fruits-vegetables and/or oat bran and/or wheat bran) was indicated in the usual diet over eight weeks. RESULTS: the sample consisted of 30 participants from the Mutual Aid Group diagnosed with MS, with an average age of 37.26 years, starting from a body mass index (BMI) of 30.75 kg/cm2 and levels of fasting glycemia at 153.87 mg/dl, triglycerides at 209.67 mg/dl, and cholesterol at 213.81 mg/dl. Following the intervention, a statistically significant difference (p < 0.05) was obtained with a BMI of 29.7 kg/cm2, fasting glycemia at 127.77 mg/dl, triglycerides at 179.71 mg/dl and cholesterol at 207.13 mg/dl. CONCLUSION: a reduction in the results for the parameters tested in patients of MS is improved by a greater consumption of dietary fiber, such as oat bran. However, additional studies are required to generate clearer recommendations.
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Fibras de la Dieta/uso terapéutico , Síndrome Metabólico/dietoterapia , Adulto , Glucemia/análisis , Índice de Masa Corporal , Femenino , Humanos , Lípidos/sangre , Estudios Longitudinales , Masculino , Estado NutricionalRESUMEN
El objetivo del presente trabajo es evaluar la microencapsulación de ácidos humícos y fúlvicos para ser empleados en la fertilización a través de la liberación controlada para plantas de ornato con un alto valor comercial, con ello se busca generar una alternativa de reducción en el impacto ambiental provocado por otros tipos de fertilizantes para los mismos fines, es importante mencionar que la producción de plantas de ornato es considerada como una industria que requiere de costos elevados durante su iniciación y mantenimiento, destacando el incremento de costos debido a la utilización de materiales importados tales como: vermiculitas, lana roca, turbas, muzgos, nitrato de potasio, nitrato de calcio y fosfonitratos, se debe tomar en cuenta que los productos comerciales más utilizados para la fertilización han demostrado poseer propiedades fisicoquímicas adecuadas para el desarrollo de los cultivos por lo tanto, el desarrollo de fertilizantes alternativos a los tradicionales habrán de cuidar de manera especial dichos aspectos, además de no ocasionar daño al suelo evitando así la generación de contaminantes residuales.(AU)
The objective of this work is to evaluate the microencapsulation of humic and fulvic acids to be used in fertilization through controlled release for ornamental plants with a high commercial value, thereby seeking to generate an alternative to reduce the impact environmental caused by other types of fertilizers for the same purposes, it is important to mention that the production of ornamental plants is considered as an industry that requires high costs during its initiation and maintenance, highlighting the increase in costs due to the use of imported materials such as: vermiculites, rock wool, peat, muzgos, potassium nitrate, calcium nitrate and phosphonitrate, it should be taken into account that the most used commercial products for fertilization have shown to have adequate physicochemical properties for the development of crops, therefore, the development of alternative fertilizers to the traditional ones will have to take special care of these aspects, in addition to not causing damage to the soil, thus avoiding the generation of residual contaminants.(AU)
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Humanos , Composición de Medicamentos , Sustancias Húmicas , Fertilización , Productos para Jardinería , Fertilizantes , Ambiente , Importación de Productos , Materia Orgánica , Suelo , Desarrollo de la PlantaRESUMEN
OBJECTIVE: Prostaglandins present in seminal fluid are actively involved in vascular and non-vascular smooth muscle maintenance, reproduction, and inflammatory processes. Seminal plasma contains molecules, such as oxylipins, which possess cell signaling functions. Several studies have shown that specific molecules in seminal fluid can increase passive diffusion, and cause interactions in the female reproductive tract. This may provoke a cascade of cellular and molecular changes in general health and certain diseases. This study examines the hypothesis that the molecules in seminal fluid are involved in platelet activity. The molecules diffuse through cells and membranes, affecting Hoxa 10, binding ganglioside pathways, and acting over platelet function. When these molecules are at low levels, they may trigger prothrombotic states, explaining the pathophysiology of haemostatic response, such as preeclampsia, and increased risk of cardiovascular disease.
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Plaquetas/metabolismo , Preeclampsia/metabolismo , Semen/metabolismo , Animales , Enfermedades Cardiovasculares/metabolismo , Endometrio/metabolismo , Femenino , Gangliósidos/metabolismo , Inflamación , Masculino , Modelos Teóricos , Oxilipinas/metabolismo , Pruebas de Función Plaquetaria , Embarazo , Prostaglandinas/metabolismo , Transducción de SeñalRESUMEN
OBJECTIVE: nutritional components such as antioxidants may modify the risk of Macular Degeneration Age-related (AMD). This article is a systematic review of published studies relating to the modification of lifestyle, nutrition and vitamin intake to prevent or delay the onset or progression of Macular Degeneration Age-related (AMD). RESULTS: the analysis of the results of research consulted shows that AMD is one of the most common causes of blindness in individuals over 55 years. AMD is characterized by decreased vision, metamorphopsias, macropsias, micropsias and central scotoma. Disease that must be diagnosed early because it can lead to irreversible blindness. Between components of the diet in many epidemiological studies have shown an inverse association with AMD and are reviewed in this paper are: vitamins (vitamin E and C), minerals (eg. zinc, selenium, manganese and copper) and carotenoids. CONCLUSIONS: there is substantial evidence that can be applied nutritional support for patients with AMD. This requires determining the nutritional benefits of these nutrients (vitamins, minerals and carotenoids) or nutraceutical foods for health in this group of patients.
Objetivo: componentes nutricionales como los antioxidantes pueden modificar el riesgo de padecer Degeneración Macular Relacionada con la Edad (DMRE). Este es un artículo de revisión sistemática de estudios publicados relacionados con la modificación del estilo de vida, la nutrición y la ingesta de vitaminas para prevenir o retrasar la aparición o progresión de la DMRE. Resultados: el análisis de los resultados de investigación consultados pone de manifiesto que la DMRE es una de las causas de ceguera más frecuentes en sujetos mayores de 55 años. La DMRE se caracteriza por disminución de la visión, metamorfosias, macropsias, micropsias y escotoma central. Es una enfermedad que debe ser diagnosticada a tiempo, ya que puede conducir a la ceguera irreversible. Entre los componentes de la dieta que en numerosos estudios epidemiológicos han mostrado una asociación inversa con la DMRE y que se revisan en este trabajo se encuentran: vitaminas (E y C), minerales (ej. zinc, selenio, manganeso y cobre) y carotenoides. Conclusiones: existe una evidencia importante de que puede aplicarse un soporte nutricional a pacientes con DMRE. Esto requiere de la determinación de los beneficios nutricionales de estos nutrientes (vitaminas, minerales y carotenoides), o bien de alimentos nutracéuticos en pro de la salud de este grupo de enfermos.
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Degeneración Macular/epidemiología , Degeneración Macular/etiología , Micronutrientes , Estado Nutricional , Valor Nutritivo , Suplementos Dietéticos , Humanos , Degeneración Macular/diagnósticoRESUMEN
OBJECTIVE: to show reviewed information of published studies relating to Familial Hypercholesterolemia (FH), nutrition, and genes involved in the development of this pathology. RESULTS: an analysis showing familial hypercholesterolemia as a disorder occuring due to mutations in gene encoding of the LDL receptor, which can be transmitted as an autosomal dominant or autosomal recessive. It's diagnosis is important for those with a greater likelihood of premature coronary disease, and can significantly reduce life expectancy. CONCLUSIONS: there are no specific clinical criteria with absolute predictive value for the diagnosis of HF, Genetic diagnosis can prove functional defects in the LDL receptor gene, constituting definitive confirmation of the diagnosis, thus the importance of presenting a genetic vision of development of this disease, which can be treated adequately through diet therapy affecting future generations in the family concerned.
Objetivo: mostrar información revisada de manera sistemática de estudios publicados relacionados con la hipercolesterolemia familiar (HF), la nutrición y los genes que intervienen en el desarrollo de esta patología. Resultados: el análisis de los resultados de investigación consultados pone de manifiesto que la hipercolesterolemia familiar es un trastorno que se produce debido a mutaciones en genes que codifican el receptor de LDL, que se puede transmitir de forma autosómica dominante o bien autosómica recesiva. La importancia de su diagnóstico radica en que las personas afectas presentan una elevada frecuencia de enfermedad coronaria prematura, reduciéndose de forma importante su expectativa de vida. Conclusiones: no existen criterios clínicos específicos con un valor predictivo absoluto para el diagnóstico de HF; el diagnóstico genético permite demostrar defectos funcionales en el gen del receptor LDL, constituyendo la confirmación definitiva del diagnóstico, de ahí la importancia de presentar una visión genética del desarrollo de esta patología, que puede ser tratada para generaciones futuras de manera adecuada a través de la dietoterapia en la familia afectada.
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Hiperlipoproteinemia Tipo II/genética , Pruebas Genéticas , Humanos , Hiperlipoproteinemia Tipo II/diagnóstico , Receptores de LDL/genéticaRESUMEN
BACKGROUND: Patients with metabolic syndrome (MS) often have increased platelet aggregation. In order to determine which concentration detects a higher level of platelet aggregation in patients with MS, the agonists ADP and epinephrine were compared. METHODS: The study included 56 subjects with MS and 53 healthy subjects. Blood pressure, weight, body-mass index, and hip-to-waist ratio were collected from all subjects. Insulin, glucose, total serum cholesterol, HDL-C, LDL-C, total triglycerides, markers of plasma atherogenicity, and indices of insulin resistance were measured in all participants. For aggregometry assays, the Born method was used. Platelets were treated with ADP and epinephrine in decreasing concentrations of 2.34, 1.17, and 0.58 µM, as well as, 11.0, 1.1, and 0.55 µM, respectively. ROC curves were plotted to define the diagnostic efficiency of epinephrine levels for MS. RESULTS: Among healthy individuals and MS patients significant differences were observed in body weight, body-mass index, waist-circumference, levels of insulin, indices of insulin resistance, and levels of HDL-cholesterol, LDL-cholesterol and total triglycerides. There was a significant difference in the detection of increased platelet aggregation using 11.0 µM and 0.55 µM epinephrine and 0.58 µM ADP. With both agonists, ROC analysis showed an area under the curve of >0.8 for 11.0 µM epinephrine and 2.34 µM ADP. However, for MS patients, 11.0 µM epinephrine had a slightly better diagnostic efficiency than 2.34 µM ADP. CONCLUSIONS: It was found that 11.0 µM epinephrine and 2.34 µM ADP detected better platelet aggregation in patients with MS than in healthy subject. Both concentrations detected increased platelet aggregation in patients with MS.
RESUMEN
Introducción: la fibra ingerida por la población en Latinoamérica es inferior (10-20 g/d) a lo recomendado por la Organización Mundial de la Salud (OMS) (25-35 g/d). Su consumo se debe promover para pacientes con síndrome metabólico (SM), ya que reduce el riesgo cardiovascular y previene la obesidad y alteraciones asociadas. Objetivo: evaluar si el incremento del consumo de fibra dietética como coadyuvante para el tratamiento de SM en sujetos del Centro de Salud de San Martín Mexicapam "La Joya", Oaxaca (México), mejora los parámetros clínicos y laboratoriales de los mismos. Métodos: se trató de un estudio analítico-longitudinal llevado a cabo desde enero hasta abril de 2017, en el cual se evaluó el estado nutricional antes y después de la intervención con fibra dietética y se midieron los niveles de colesterol, triglicéridos y glucosa en sangre en ayuno. Se indicó un incremento de 15 g de fibra (frutas-verduras y/o salvado de avena y/o salvado de trigo) a la dieta habitual por un lapso continuo de ocho semanas. Resultados: la muestra fue de 30 participantes del Grupo de Ayuda Mutua diagnosticados con SM, cuya media de edad fue de 37,26 años y con un índice de masa corporal (IMC) al inicio de 30,75 kg/cm2, glucemia de ayuno de 153,87 mg/dl, triglicéridos de 209,67 mg/dl y colesterol de 213,81 mg/dl. Al finalizar la intervención se obtuvo una diferencia estadísticamente significativa (p < 0,05): IMC de 29,7 kg/cm2, glucemia de ayuno de 127,77 mg/dl, triglicéridos de 179,71 mg/dl y colesterol de 207,13 mg/dl. Conclusión: el incremento del consumo de fibra dietética (salvado de avena) funciona como complemento al tratamiento del SM para disminuir los parámetros clínicos y laboratoriales de los sujetos de estudio. Sin embargo, se requiere de más estudios para generar recomendaciones más claras
Introduction: the amount of fiber ingested in Latin American countries is lower (10-20 g/d) than recommended (35 g/d). An increase is recommended for patients with metabolic syndrome (MS) to reduce cardiovascular risk, as well as to prevent obesity and other complications. Objective: to evaluate whether increased dietary fiber consumption complements MS treatment and improves clinical and laboratory parameters in subjects at the San Martin Mexicapam "La Joya" Health Center, Oaxaca (Mexico). Methods: an analytical-longitudinal study was carried out from January to April 2017, to evaluate nutritional status before and after intervention with dietary fiber and to measure cholesterol levels, triglycerides and fasting blood glucose. An increase of 15 g of fiber (fruits-vegetables and/ or oat bran and/or wheat bran) was indicated in the usual diet over eight weeks. Results: the sample consisted of 30 participants from the Mutual Aid Group diagnosed with MS, with an average age of 37.26 years, starting from a body mass index (BMI) of 30.75 kg/cm2 and levels of fasting glycemia at 153.87 mg/dl, triglycerides at 209.67 mg/dl, and cholesterol at 213.81 mg/dl. Following the intervention, a statistically significant difference (p < 0.05) was obtained with a BMI of 29.7 kg/cm2, fasting glycemia at 127.77 mg/dl, triglycerides at 179.71 mg/dl and cholesterol at 207.13 mg/dl. Conclusion: a reduction in the results for the parameters tested in patients of MS is improved by a greater consumption of dietary fiber, such as oat bran. However, additional studies are required to generate clearer recommendations
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Fibras de la Dieta/uso terapéutico , Glucemia/análisis , Índice de Masa Corporal , Lípidos/sangre , Estudios Longitudinales , Estado NutricionalRESUMEN
Introducción: los grupos de ayuda mutua se forman con la finalidad de atender a adultos mayores con problemas crónicos-degenerativos. La organización y participación activa de los integrantes favorece la intervención del nutriólogo y, por ende, cambios en el estilo de vida de los participantes, sobrellevando de mejor manera sus vidas. Objetivo: intervenir nutricionalmente en individuos del Grupo de Ayuda Mutua del Centro de Salud C-2, "El Rosario" de Oaxaca de Juárez, México. Material y métodos: se trató de un estudio observacional, descriptivo, analítico y longitudinal, llevado a cabo desde noviembre/2014 hasta julio/2015, evaluando el estado nutricional antes y después de la intervención, buscando la correlación entre índice de masa corporal (IMC), glucosa capilar, hemoglobina glicada con las consultas-talleres brindadas. Resultados: la muestra trabajada fue de 15 participantes del Grupo de Ayuda Mutua con un promedio de edad de 55,26 años, con un IMC de 28,74 kg/cm 2 , glucosa capilar de 218,66 mg/dl y una hemoglobina glicada de 10,43%. Al finalizar la intervención se correlacionaron entre sí mediante Spearman, dando como resultado el valor de 1, es decir, una correlación positiva perfecta. Conclusión: el nutriólogo juega hoy en día un papel importante en el hecho de atender enfermedades crónico-degenerativas, a través del seguimiento en consultas y talleres propuestos. Los grupos de ayuda mutua día a día se posicionan como una estrategia en la línea educativa para mejorar el control de las enfermedades.