1.
Bioorg Med Chem Lett
; 18(6): 1889-92, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18321704
RESUMEN
Protein prenyl transferases have been a focus of anti-cancer drug discovery in recent years due to their roles in post-translational modification of small GTP binding proteins. Attention is now turning to the development of GGTase I inhibitors. Here, we present the synthesis and biological evaluation of four GGPP analogs versus mammalian GGTase I and the discovery that 7-allyl GGPP is a surprisingly efficient GGTase I substrate.