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2.
Front Med (Lausanne) ; 8: 636160, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33777979

RESUMEN

Healthcare workers (HCWs) are known to be at increased risk of infection with SARS-CoV-2, although whether these risks are equal across all roles is uncertain. Here we report a retrospective analysis of a large real-world dataset obtained from 10 March to 6 July 2020 in an NHS Foundation Trust in England with 17,126 employees. 3,338 HCWs underwent symptomatic PCR testing (14.4% positive, 2.8% of all staff) and 11,103 HCWs underwent serological testing for SARS-CoV-2 IgG (8.4% positive, 5.5% of all staff). Seropositivity was lower than other hospital settings in England but higher than community estimates. Increased test positivity rates were observed in HCWs from BAME backgrounds and residents in areas of higher social deprivation. A multiple logistic regression model adjusting for ethnicity and social deprivation confirmed statistically significant increases in the odds of testing positive in certain occupational groups, most notably domestic services staff, nurses, and health-care assistants. PCR testing of symptomatic HCWs appeared to underestimate overall infection levels, probably due to asymptomatic seroconversion. Clinical outcomes were reassuring, with only a small minority of HCWs with COVID-19 requiring hospitalization (2.3%) or ICU management (0.7%) and with no deaths. Despite a relatively low level of HCW infection compared to other UK cohorts, there were nevertheless important differences in test positivity rates between occupational groups, robust to adjustment for demographic factors such as ethnic background and social deprivation. Quantitative and qualitative studies are needed to better understand the factors contributing to this risk. Robust informatics solutions for HCW exposure data are essential to inform occupational monitoring.

3.
Rev Sci Instrum ; 83(5): 055102, 2012 May.
Artículo en Inglés | MEDLINE | ID: mdl-22667652

RESUMEN

We report on a directional atomic beam created using an alkali metal dispenser and a nozzle. By applying a high current (15 A) pulse to the dispenser at room temperature we can rapidly heat it to a temperature at which it starts dispensing, avoiding the need for preheating. The atomic beam produced is capable of loading 90% of a magneto-optical trap (MOT) in less than 7 s while maintaining a low vacuum pressure of <10(-11) Torr. The transverse velocity components of the atomic beam are measured to be within typical capture velocities of a rubidium MOT. Finally, we show that the atomic beam can be turned off within 1.8 s.

4.
Rev Sci Instrum ; 80(5): 053101, 2009 May.
Artículo en Inglés | MEDLINE | ID: mdl-19485486

RESUMEN

We report on an inexpensive commercial laser diode stabilized to the D(2)-line in rubidium using a simple scheme. The linewidth was reduced to 1.3 MHz without an external cavity, making it suitable for laser cooling and trapping. The system is very robust and the laser frequency can be changed rapidly (within 51 micros) while the laser remains in lock. The frequency of the locked laser drifts less than 850 kHz peak-to-peak over 25 h. We demonstrate laser cooling and trapping using our system.

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