The formation of araneiforms by carbon dioxide venting and vigorous sublimation dynamics under martian atmospheric pressure.

The local redistribution of granular material by sublimation of the southern seasonal [Formula: see text] ice deposit is one of the most active surface shaping processes on Mars today. This unique geomorphic mechanism is hypothesised to be the cause of the dendritic, branching, spider-like araneiform terrain and associated fans and spots-features which are native to Mars and have no Earth analogues. However, there is a paucity of empirical data to test the validity of this hypothesis. Additionally, it is unclear whether some araneiform patterns began as radial and then grew outward, or whether troughs connected at mutual centres over time. Here we present the results of a suite of laboratory experiments undertaken to investigate if the interaction between a sublimating [Formula: see text] ice overburden containing central vents and a porous, mobile regolith will mobilise grains from beneath the ice in the form of a plume to generate araneiform patterns. We quantify the branching and area of the dendritic features that form. We provide the first observations of plume activity via [Formula: see text] sublimation and consequent erosion to form araneiform features. We show that [Formula: see text] sublimation can be a highly efficient agent of sediment transport under present day Martian atmospheric pressure and that morphometry is governed by the Shields parameter.

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.

Increased eukaryotic translation initiation factor 4E (eIF4E) expression occurs in many cancers, and makes fundamental contributions to carcinogenesis by stimulating the expression of cancer-related genes at post-transcriptional levels. This key role is highlighted by the facts that eIF4E levels can predict prognosis, and that eIF4E is an established therapeutic target. However, eIF4E activity is a complex function of expression levels and phosphorylation statuses of eIF4E and eIF4E-binding proteins (4E-BPs). Our hypothesis was that the combined analyses of these pathway components would allow insights into eIF4E activity and its influence on cancer. We have determined expression levels of eIF4E, 4E-BP1, 4E-BP2 and phosphorylated 4E-BP1 within 424 breast tumours, and have carried out analyses to combine these and relate the product to patient survival, in order to estimate eIF4E activity. We show that this analysis gives greater prognostic insights than that of eIF4E alone. We show that eIF4E and 4E-BP expression are positively associated, and that 4E-BP2 has a stronger influence on cancer behaviour than 4E-BP1. Finally, we examine eIF4E, estimated eIF4E activity, and phosphorylated 4E-BP1 as potential predictive biomarkers for eIF4E-targeted therapies, and show that each determines selection of different patient groups. We conclude that eIF4E's influence on cancer survival is modulated substantially by 4E-BPs, and that combined pathway analyses can estimate functional eIF4E.

Initiation and Flow Conditions of Contemporary Flows in Martian Gullies.

Understanding the initial and flow conditions of contemporary flows in Martian gullies, generally believed to be triggered and fluidized by CO2 sublimation, is crucial for deciphering climate conditions needed to trigger and sustain them. We employ the RAMMS (RApid Mass Movement Simulation) debris flow and avalanche model to back calculate initial and flow conditions of recent flows in three gullies in Hale crater. We infer minimum release depths of 1.0-1.5 m and initial release volumes of 100-200 m3. Entrainment leads to final flow volumes that are ∼2.5-5.5 times larger than initially released, and entrainment is found necessary to match the observed flow deposits. Simulated mean cross-channel flow velocities decrease from 3-4 m/s to ∼1 m/s from release area to flow terminus, while flow depths generally decrease from 0.5-1 to 0.1-0.2 m. The mean cross-channel erosion depth and deposition thicknesses are ∼0.1-0.3 m. Back-calculated dry-Coulomb friction ranges from 0.1 to 0.25 and viscous-turbulent friction between 100 and 200 m/s2, which are values similar to those of granular debris flows on Earth. These results suggest that recent flows in gullies are fluidized to a similar degree as are granular debris flows on Earth. Using a novel model for mass flow fluidization by CO2 sublimation we are able to show that under Martian atmospheric conditions very small volumetric fractions of CO2 of ≪1% within mass flows may indeed yield sufficiently large gas fluxes to cause fluidization and enhance flow mobility.

Comparing flow thresholds and dynamics for oscillating and inclined granular layers.

The onset and dynamics of flow in shallow horizontally oscillating granular layers are studied as a function of the depth of the layer and imposed acceleration. Measurements of the flow velocity made from the top and side are presented in the frame of reference of the container. As is also found for avalanches of inclined layers, the thresholds for starting and stopping of flow are slightly different. The variation with depth of the starting acceleration Gamma{start} for the oscillating layer is similar to the corresponding variation of the tangent of the starting angle tan(theta{start}) for avalanches in the same container at low frequencies, but deviates as the frequency is increased. However, the threshold behavior depends significantly on the measurement protocol. Just above Gamma{start} , the motion decays with time as the material reorganizes over a minute or so, causing the apparent threshold to increase. Furthermore, the rms velocity as a function of acceleration rises more sharply above the starting threshold if the first minute or so of excitation is discarded. Once excited, the rheology of the material is found to vary in time during the cycle in surprising ways. If the maximum inertial force (proportional to the container acceleration amplitude) is slightly higher than that required to produce flow, the flow velocity grows as soon as the inertial force exceeds zero in each cycle, but jamming occurs long before the inertial force returns to zero. At higher Gamma , the motion is fluidlike over the entire cycle. However, the fraction of the cycle during which the layer is mobile is typically far higher than what one would predict from static considerations or the behavior of the inclined layer. Finally, we consider the flow profiles as a function of both the transverse distance across the cell at the free surface and also as a function of the vertical coordinate in the boundary layer near the sidewall. These profiles have time-dependent shapes and are therefore significantly different from profiles previously measured for avalanche flows.

Experiments On Sublimating Carbon Dioxide Ice And Implications For Contemporary Surface Processes On Mars.

Carbon dioxide is Mars' primary atmospheric constituent and is an active driver of Martian surface evolution. CO2 ice sublimation mechanisms have been proposed for a host of features that form in the contemporary Martian climate. However, there has been very little experimental work or quantitative modelling to test the validity of these hypotheses. Here we present the results of the first laboratory experiments undertaken to investigate if the interaction between sublimating CO2 ice blocks and a warm, porous, mobile regolith can generate features similar in morphology to those forming on Martian dunes today. We find that CO2 sublimation can mobilise grains to form (i) pits and (ii) furrows. We have documented new detached pits at the termini of linear gullies on Martian dunes. Based on their geomorphic similarity to the features observed in our laboratory experiments, and on scaling arguments, we propose a new hypothesis that detached pits are formed by the impact of granular jets generated by sublimating CO2. We also study the erosion patterns formed underneath a sublimating block of CO2 ice and demonstrate that these resemble furrow patterns on Mars, suggesting similar formation mechanisms.

Phase diagram for inertial granular flows.

Flows of hard granular materials depend strongly on the interparticle friction coefficient µ_{p} and on the inertial number I, which characterizes proximity to the jamming transition where flow stops. Guided by numerical simulations, we derive the phase diagram of dense inertial flow of spherical particles, finding three regimes for 10^{-4}≲I≲10^{-1}: frictionless, frictional sliding, and rolling. These are distinguished by the dominant means of energy dissipation, changing from collisional to sliding friction, and back to collisional, as µ_{p} increases from zero at constant I. The three regimes differ in their kinetics and rheology; in particular, the velocity fluctuations and the stress ratio both display nonmonotonic behavior with µ_{p}, corresponding to transitions between the three regimes of flow. We rationalize the phase boundaries between these regimes, show that energy balance yields scaling relations between microscopic properties in each of them, and derive the strain scale at which particles lose memory of their velocity. For the frictional sliding regime most relevant experimentally, we find for I≥10^{-2.5} that the growth of the macroscopic friction µ(I) with I is induced by an increase of collisional dissipation. This implies in that range that µ(I)-µ(0)∼I^{1-2b}, where b≈0.2 is an exponent that characterizes both the dimensionless velocity fluctuations L∼I^{-b} and the density of sliding contacts χ∼I^{b}.

Mathematical and biological modelling of RNA secondary structure and its effects on gene expression.

Secondary structures within the 5' untranslated regions of messenger RNAs can have profound effects on the efficiency of translation of their messages and thereby on gene expression. Consequently they can act as important regulatory motifs in both physiological and pathological settings. Current approaches to predicting the secondary structure of these RNA sequences find the structure with the global-minimum free energy. However, since RNA folds progressively from the 5' end when synthesised or released from the translational machinery, this may not be the most probable structure. We discuss secondary structure prediction based on local-minimisation of free energy with thermodynamic fluctuations as nucleotides are added to the 3' end and show that these can result in different secondary structures. We also discuss approaches for studying the extent of the translational inhibition specified by structures within the 5' untranslated region.

Rotational flow in gravity current heads.

The structure of gravity currents and plumes, in an unbounded ambient, on a slope of arbitrary angle is analysed. Inviscid, rotational flow solutions in a wedge are used to study the flow near the front of a current, and used to show that the Froude number is radical2 and the angle of the front to the slope is 60 degrees. This extends the result of von Kármán (1940) to arbitrary slope angles and large internal current velocities. The predictions of the theory are briefly compared with experiments and used to explain the large negative (relative to ambient) pressures involved in avalanches.