1.
J Infect Dis
; 2024 Mar 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38441336
RESUMEN
We previously described a novel Plasmodium vivax invasion mechanism into human reticulocytes via the PvRBP2a-CD98 receptor-ligand pair. We assessed the PvRBP2a epitopes involved in CD98 binding and recognised by antibodies from infected patients using linear epitope mapping. We identified two epitope clusters mediating PvRBP2a-CD98 interaction. One cluster named cluster B (PvRBP2a431-448, TAALKEKGKLLANLYNKL) was the target of antibody responses in P. vivax-infected humans. Peptides from each cluster were able to prevent live parasite invasion of human reticulocytes. These results provide new insights for development of a malaria blood stage vaccine against P. vivax.
2.
PLoS Med
; 5(6): e133, 2008 Jun 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18563964