Synthesis, characterization, and theoretical studies of metal complexes derived from the chiral tripyridyldiamine ligand Bn-CDPy3.

Synthesis and characterization of metal complexes of the chiral tripyridyldiamine ligand Bn-CDPy3 (1), derived from trans-1,2-diaminocyclohexane, are described, along with theoretical studies that support the experimental data. These studies confirm that a single coordination geometry, out of five possible, is favored for octahedral complexes of the type [M(Bn-CDPy3)Cl], where M equals Co(III), Fe(II), and Zn(II). A combination of X-ray crystallographic and NMR spectroscopic methods was used to define the structures of the complexes [Co(Bn-CDPy3)Cl]Cl(2) (5), [Fe(Bn-CDPy3)Cl]X (X = FeCl(4), Cl, ClO(4), 6-8), and [Zn(Bn-CDPy3)Cl](2)ZnCl(4) (9) in the solid state and in solution. Experimental and theoretical data indicate that the most stable coordination geometry for all complexes possesses the Cl group trans to a basic amine donor and three pyridyl donors adopting the mer geometry, with two pyridyl N-donors adopting a coplanar geometry with respect to the M-Cl bond and the third pyridyl donor perpendicular to that axis. Calculations indicate that the ability to favor a single geometry is born from the chiral ligand, which prefers to be in a single conformation in metal complexes due to steric interactions and electronic factors. Calculated structures of the complexes were used to locate key interactions among the various diastereomeric complexes that are proposed to create an energetic preference for the coordination geometry observed in the metal complexes of 1.

An Evidence-based, Longitudinal Curriculum for Resident Physician Wellness: The 2017 Resident Wellness Consensus Summit.

INTRODUCTION: Physicians are at much higher risk for burnout, depression, and suicide than their non-medical peers. One of the working groups from the May 2017 Resident Wellness Consensus Summit (RWCS) addressed this issue through the development of a longitudinal residency curriculum to address resident wellness and burnout. METHODS: A 30-person (27 residents, three attending physicians) Wellness Curriculum Development workgroup developed the curriculum in two phases. In the first phase, the workgroup worked asynchronously in the Wellness Think Tank - an online resident community - conducting a literature review to identify 10 core topics. In the second phase, the workgroup expanded to include residents outside the Wellness Think Tank at the live RWCS event to identify gaps in the curriculum. This resulted in an additional seven core topics. RESULTS: Seventeen foundational topics served as the framework for the longitudinal resident wellness curriculum. The curriculum includes a two-module introduction to wellness; a seven-module "Self-Care Series" focusing on the appropriate structure of wellness activities and everyday necessities that promote physician wellness; a two-module section on physician suicide and self-help; a four-module "Clinical Care Series" focusing on delivering bad news, navigating difficult patient encounters, dealing with difficult consultants and staff members, and debriefing traumatic events in the emergency department; wellness in the workplace; and dealing with medical errors and shame. CONCLUSION: The resident wellness curriculum, derived from an evidence-based approach and input of residents from the Wellness Think Tank and the RWCS event, provides a guiding framework for residency programs in emergency medicine and potentially other specialties to improve physician wellness and promote a culture of wellness.

Synthesis of the chiral tripyridyldiamine ligand Bn-CDPy3 and characterization of its Co(III) complex [Co(Bn-CDPy3)Cl]Cl2.

Synthesis of the tripyridyldiamine Bn-CDPy3, a chiral pentadentate ligand, and characterization of its low-spin Co(III) complex [Co(Bn-CDPy3)Cl]Cl2 by X-ray crystallography, 1H NMR, 13C NMR, IR and UV-vis spectroscopy as well as molar conductivity and mass spectrometry, is described.