Búsqueda | BVS CLAP/SMR-OPS/OMS

1.

Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α.

Shalova, Irina N; Lim, Jyue Yuan; Chittezhath, Manesh; Zinkernagel, Annelies S; Beasley, Federico; Hernández-Jiménez, Enrique; Toledano, Victor; Cubillos-Zapata, Carolina; Rapisarda, Annamaria; Chen, Jinmiao; Duan, Kaibo; Yang, Henry; Poidinger, Michael; Melillo, Giovanni; Nizet, Victor; Arnalich, Francisco; López-Collazo, Eduardo; Biswas, Subhra K.

Immunity ; 42(3): 484-98, 2015 Mar 17.

Artículo en Inglés | MEDLINE | ID: mdl-25746953

2.

Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC.

Antonia, Scott J; Villegas, Augusto; Daniel, Davey; Vicente, David; Murakami, Shuji; Hui, Rina; Kurata, Takayasu; Chiappori, Alberto; Lee, Ki H; de Wit, Maike; Cho, Byoung C; Bourhaba, Maryam; Quantin, Xavier; Tokito, Takaaki; Mekhail, Tarek; Planchard, David; Kim, Young-Chul; Karapetis, Christos S; Hiret, Sandrine; Ostoros, Gyula; Kubota, Kaoru; Gray, Jhanelle E; Paz-Ares, Luis; de Castro Carpeño, Javier; Faivre-Finn, Corinne; Reck, Martin; Vansteenkiste, Johan; Spigel, David R; Wadsworth, Catherine; Melillo, Giovanni; Taboada, Maria; Dennis, Phillip A; Özgüroglu, Mustafa.

N Engl J Med ; 379(24): 2342-2350, 2018 12 13.

Artículo en Inglés | MEDLINE | ID: mdl-30280658

3.

Durvalumab after Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.

Antonia, Scott J; Villegas, Augusto; Daniel, Davey; Vicente, David; Murakami, Shuji; Hui, Rina; Yokoi, Takashi; Chiappori, Alberto; Lee, Ki H; de Wit, Maike; Cho, Byoung C; Bourhaba, Maryam; Quantin, Xavier; Tokito, Takaaki; Mekhail, Tarek; Planchard, David; Kim, Young-Chul; Karapetis, Christos S; Hiret, Sandrine; Ostoros, Gyula; Kubota, Kaoru; Gray, Jhanelle E; Paz-Ares, Luis; de Castro Carpeño, Javier; Wadsworth, Catherine; Melillo, Giovanni; Jiang, Haiyi; Huang, Yifan; Dennis, Phillip A; Özgüroglu, Mustafa.

N Engl J Med ; 377(20): 1919-1929, 2017 11 16.

Artículo en Inglés | MEDLINE | ID: mdl-28885881

4.

SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.

Pai, Sara I; Cohen, Ezra E W; Lin, Derrick; Fountzilas, George; Kim, Edward S; Mehlhorn, Holger; Baste, Neus; Clayburgh, Daniel; Lipworth, Loren; Resteghini, Carlo; Shara, Nawar; Fujii, Takashi; Zhang, Jun; Stokes, Michael; Wang, Huifen; Twumasi-Ankrah, Philip; Wildsmith, Sophie; Khaliq, Asud; Melillo, Giovanni; Shire, Norah.

J Transl Med ; 17(1): 429, 2019 12 26.

Artículo en Inglés | MEDLINE | ID: mdl-31878938

5.

NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction.

Juhasz, Agnes; Markel, Susan; Gaur, Shikha; Liu, Han; Lu, Jiamo; Jiang, Guojian; Wu, Xiwei; Antony, Smitha; Wu, Yongzhong; Melillo, Giovanni; Meitzler, Jennifer L; Haines, Diana C; Butcher, Donna; Roy, Krishnendu; Doroshow, James H.

J Biol Chem ; 292(19): 7866-7887, 2017 05 12.

Artículo en Inglés | MEDLINE | ID: mdl-28330872

6.

Weekly EZN-2208 (PEGylated SN-38) in combination with bevacizumab in patients with refractory solid tumors.

Jeong, Woondong; Park, Sook Ryun; Rapisarda, Annamaria; Fer, Nicole; Kinders, Robert J; Chen, Alice; Melillo, Giovanni; Turkbey, Baris; Steinberg, Seth M; Choyke, Peter; Doroshow, James H; Kummar, Shivaani.

Invest New Drugs ; 32(2): 340-6, 2014 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-24242862

7.

Hypoxia: jump-starting inflammation.

Melillo, Giovanni.

Blood ; 117(9): 2561-2, 2011 Mar 03.

Artículo en Inglés | MEDLINE | ID: mdl-21372159

8.

Association of PD-L1 Expression on Tumor and Immune Cells with Survival in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Assay Validation.

Wildsmith, Sophie; Ye, Jiabu; Franks, April; Melillo, Giovanni; Armstrong, Jon; Whiteley, Jessica; Schnittker, Karina; Lian, Fangru; Roland, Bryan; Sabalos, Constantine; Ahmadi, Payam; Fayette, Jerome; Even, Caroline; Mesía, Ricard; Siu, Lillian L; Zandberg, Dan P; Walker, Jill.

Cancer Res Commun ; 2(1): 39-48, 2022 01.

Artículo en Inglés | MEDLINE | ID: mdl-36860696

9.

Curative-Intent Treatment with Durvalumab in Early-Stage Cancers.

Melillo, Giovanni; Chand, Vikram; Yovine, Alejandro; Gupta, Ashok; Massacesi, Cristian.

Adv Ther ; 38(6): 2759-2778, 2021 06.

Artículo en Inglés | MEDLINE | ID: mdl-33881745

10.

Regulation of the chemokine receptor CXCR4 by hypoxia.

Schioppa, Tiziana; Uranchimeg, Badarch; Saccani, Alessandra; Biswas, Subhra K; Doni, Andrea; Rapisarda, Annamaria; Bernasconi, Sergio; Saccani, Simona; Nebuloni, Manuela; Vago, Luca; Mantovani, Alberto; Melillo, Giovanni; Sica, Antonio.

J Exp Med ; 198(9): 1391-402, 2003 Nov 03.

Artículo en Inglés | MEDLINE | ID: mdl-14597738

11.

Endothelial monocyte activating polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible factor-1alpha through interaction with PSMA7, a component of the proteasome.

Tandle, Anita T; Calvani, Maura; Uranchimeg, Badarch; Zahavi, David; Melillo, Giovanni; Libutti, Steven K.

Exp Cell Res ; 315(11): 1850-9, 2009 Jul 01.

Artículo en Inglés | MEDLINE | ID: mdl-19362550

12.

Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies.

Rapisarda, Annamaria; Melillo, Giovanni.

Drug Resist Updat ; 12(3): 74-80, 2009 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-19394890

13.

Development of HIF-1 inhibitors for cancer therapy.

Onnis, Barbara; Rapisarda, Annamaria; Melillo, Giovanni.

J Cell Mol Med ; 13(9A): 2780-6, 2009 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-19674190

14.

Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.

Klausmeyer, Paul; Zhou, Qin; Scudiero, Dominic A; Uranchimeg, Badarch; Melillo, Giovanni; Cardellina, John H; Shoemaker, Robert H; Chang, Ching-Jer; McCloud, Thomas G.

J Nat Prod ; 72(5): 805-12, 2009 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-19405508

15.

Safety and Efficacy of Durvalumab With or Without Tremelimumab in Patients With PD-L1-Low/Negative Recurrent or Metastatic HNSCC: The Phase 2 CONDOR Randomized Clinical Trial.

Siu, Lillian L; Even, Caroline; Mesía, Ricard; Remenar, Eva; Daste, Amaury; Delord, Jean-Pierre; Krauss, Jürgen; Saba, Nabil F; Nabell, Lisle; Ready, Neal E; Braña, Irene; Kotecki, Nuria; Zandberg, Dan P; Gilbert, Jill; Mehanna, Hisham; Bonomi, Marcelo; Jarkowski, Anthony; Melillo, Giovanni; Armstrong, Jon M; Wildsmith, Sophie; Fayette, Jérôme.

JAMA Oncol ; 5(2): 195-203, 2019 02 01.

Artículo en Inglés | MEDLINE | ID: mdl-30383184

16.

Durvalumab for recurrent or metastatic head and neck squamous cell carcinoma: Results from a single-arm, phase II study in patients with ≥25% tumour cell PD-L1 expression who have progressed on platinum-based chemotherapy.

Zandberg, Dan P; Algazi, Alain P; Jimeno, Antonio; Good, James S; Fayette, Jérôme; Bouganim, Nathaniel; Ready, Neal E; Clement, Paul M; Even, Caroline; Jang, Raymond W; Wong, Stuart; Keilholz, Ulrich; Gilbert, Jill; Fenton, Moon; Braña, Irene; Henry, Stephanie; Remenar, Eva; Papai, Zsuzsanna; Siu, Lillian L; Jarkowski, Anthony; Armstrong, Jon M; Asubonteng, Kobby; Fan, Jean; Melillo, Giovanni; Mesía, Ricard.

Eur J Cancer ; 107: 142-152, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30576970

17.

Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.

Creighton-Gutteridge, Mark; Cardellina, John H; Stephen, Andrew G; Rapisarda, Annamaria; Uranchimeg, Badarch; Hite, Karen; Denny, William A; Shoemaker, Robert H; Melillo, Giovanni.

Clin Cancer Res ; 13(3): 1010-8, 2007 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-17289897

18.

Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies.

Kummar, Shivaani; Gutierrez, Martin; Gardner, Erin R; Donovan, Erin; Hwang, Kyunghwa; Chung, Eun Joo; Lee, Min-Jung; Maynard, Kim; Kalnitskiy, Mikhail; Chen, Alice; Melillo, Giovanni; Ryan, Qin C; Conley, Barbara; Figg, William D; Trepel, Jane B; Zwiebel, James; Doroshow, James H; Murgo, Anthony J.

Clin Cancer Res ; 13(18 Pt 1): 5411-7, 2007 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-17875771

19.

Meeting report: exploiting the tumor microenvironment for therapeutics.

Melillo, Giovanni; Semenza, Gregg L.

Cancer Res ; 66(9): 4558-60, 2006 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-16651404

20.

Inhibiting hypoxia-inducible factor 1 for cancer therapy.