Detalles de la búsqueda
1.
Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation.
J Enzyme Inhib Med Chem
; 39(1): 2287990, 2024 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38062554
2.
Stereocontrolled Synthesis of α-3-Deoxy-d-manno-oct-2-ulosonic Acid (α-Kdo) Glycosides Using C3-p-Tolylthio-Substituted Kdo Donors: Access to Highly Branched Kdo Oligosaccharides.
Angew Chem Int Ed Engl
; 63(2): e202313985, 2024 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38014418
3.
Targeting 14-3-3ζ by a small-molecule compound AI-34 maintains epithelial barrier integrity and alleviates colitis in mice via stabilizing ß-catenin.
J Pharmacol Sci
; 152(4): 210-219, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37344056
4.
Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease.
Phytother Res
; 37(2): 611-626, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36325883
5.
Design, Synthesis, and Antitumor Activity Evaluation of Proteolysis-Targeting Chimeras as Degraders of Extracellular Signal-Regulated Kinases 1/2.
Int J Mol Sci
; 24(22)2023 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38003480
6.
A novel natural PPARγ agonist, Gypenoside LXXV, ameliorates cognitive deficits by enhancing brain glucose uptake via the activation of Akt/GLUT4 signaling in db/db mice.
Phytother Res
; 36(4): 1770-1784, 2022 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-35192202
7.
A novel DPP-4 inhibitor Gramcyclin A attenuates cognitive deficits in APP/PS1/tau triple transgenic mice via enhancing brain GLP-1-dependent glucose uptake.
Phytother Res
; 36(3): 1297-1309, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-35088915
8.
Folium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation.
Pharm Biol
; 60(1): 195-205, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35060427
9.
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels.
J Biol Chem
; 295(31): 10842-10856, 2020 07 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-32546483
10.
TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice.
Gastroenterology
; 158(8): 2266-2281.e27, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32105727
11.
Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice.
J Immunol
; 201(8): 2403-2413, 2018 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30185517
12.
Semisynthesis of Chondroitin Sulfate Oligosaccharides Based on the Enzymatic Degradation of Chondroitin.
J Org Chem
; 84(11): 7418-7425, 2019 06 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31066281
13.
Synthesis of Fucosylated Chondroitin Sulfate Glycoclusters: A Robust Route to New Anticoagulant Agents.
Chemistry
; 24(7): 1694-1700, 2018 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29131431
14.
Semisynthesis of Chondroitin Sulfate E Tetrasaccharide from Hyaluronic Acid.
J Org Chem
; 83(22): 14069-14077, 2018 11 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30359032
15.
Design, synthesis and structure-activity relationship study of novel naphthoindolizine and indolizinoquinoline-5,12-dione derivatives as IDO1 inhibitors.
Bioorg Med Chem
; 26(17): 4886-4897, 2018 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30170925
16.
Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice.
Int J Mol Sci
; 19(12)2018 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30544722
17.
Neuroprotective Effects of Radix Scrophulariae on Cerebral Ischemia and Reperfusion Injury via MAPK Pathways.
Molecules
; 23(9)2018 09 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30235876
18.
Correction: Meng, X., et al. Neuroprotective Effects of Radix Scrophulariae on Cerebral Ischemia and Reperfusion Injury via MAPK Pathways. Molecules 2018, 23, 2401.
Molecules
; 23(10)2018 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30347778
19.
Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice.
Molecules
; 23(3)2018 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-29495433
20.
Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology.
Molecules
; 23(4)2018 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-29673237