1.
Cell Res
; 25(2): 149-50, 2015 Feb.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25267404
RESUMEN
Inflammasomes are sensors that serve as activation platforms for caspase-1 - a mechanism that set the prevailing paradigm for inflammatory caspase activation. A recent Nature paper by Shi et al. upends this paradigm by describing an unprecedented model for caspase activation whereby caspase-4, -5, and -11 directly bind their agonist, cytosolic LPS, triggering auto-activation and subsequent pyroptotic cell death.