[Prescription of Benzodiazepines and Z-Drugs by German General Practitioners: A Cross-Sectional Study]. / Verordnung von Benzodiazepinen und Z-Drugs in hausärztlichen Praxen ­ eine Querschnittanalyse.

BACKGROUND: Due to their addictive potential, benzodiazepine (BZ) and non-benzodiazepine-agonists (NBZ, so-called Z-drugs) should be taken no longer than 6 weeks. BZ and NBZ are primarily prescribed by general practitioners (GPs). Therefore, we aimed to analyze GPs' data on the patients collective, the amount of BZ/NBZ prescribed and the rate of private prescriptions. METHODS: We analyzed person years of 2-year intervals from 2009 to 2014 of the primary care CONTENT register that contains routine data from 31 general practitioners' practices. We classified BZ/NBZ prescriptions according to risk groups. The association of BZ/NBZ prescription and potential influencing factors was analyzed by calculating the odds ratio with 95% confidence interval (and corresponding p-value) on the basis of a multiple logistic regression model (adjusted by age, sex and type of health insurance). All patients with drug prescription with and without BZ/NBZ-prescription were compared. RESULTS: Almost 5% of patients with drug prescriptions received at least one prescription of BZ/NBZ during 1 year of observation. On average these patients were older (67.5 vs. 48 years respectively) and the proportion of women was higher than in the comparison group (69 vs. 58%). About one-third of these patients received more than 600 mg diazepam equivalent dose per person year (according to a 2-month daily intake of more than 10 mg diazepam). About one-third of the prescriptions were private prescriptions. A number of variables were significantly associated with the prescription of BZ/NBZ (e. g. age, gender, diagnosis codes, practices). CONCLUSION: The results provide valuable information about BZ/NBZ prescription routines in general practice. For continuous medical education as well as the development of interventions to reduce the use of BZ/NBZ, patient characteristics (e. g. sex, age, comorbidities, type of insurance) as well as different prescription routines (e. g. private prescriptions, reason and frequency of prescriptions, guideline orientation) should be considered.

Physical examination in undergraduate medical education in the field of general practice - a scoping review.

BACKGROUND: Physical examination (PE) is an essential clinical skill and a central part of a physician's daily activity. Teaching of PE has been integrated into medical school by many clinical disciplines with respective specific examination procedures. For instance, PE teaching in general practice may include a full-body examination approach. Studies show that PE-skills of medical students often need enhancement. The aim of this article was to scope the literature regarding the teaching and research of PE within general practice during undergraduate medical education. We evaluated a wide breadth of literature relating to the content, study design, country of research institution and year of publication. METHODS: Literature search in Medline along the PRISMA-P protocol was performed by search syntax ("physical examination" AND "medical education" AND "undergraduate" AND general practice) considering Medline MeSH (Medical Subject Heading)-Terms and Medline search term tree structure. Independent title, abstract and full-text screening with defined inclusion and exclusion criteria was performed. Full texts were analyzed by publication year, country of origin, study design and content (by categorizing articles along their main topic according to qualitative content analysis of Mayring). RESULTS: One-hundred seven articles were included. The annual number of publications ranged from 4 to 14 and had a slightly rising trend since 2000. Nearly half of the publications originated from the United States (n = 54), 33 from Canada and the United Kingdom. Overall, intervention studies represented the largest group (n = 60, including uncontrolled and controlled studies, randomized and non-randomized), followed by cross-sectional studies (n = 29). The 117 studies could be assigned to five categories "teaching methods (n = 53)", "teaching quality (n = 33)", "performance evaluation and examination formats (n=19)", "students' views (n = 8)" and "patients' and standardized patients' views (n=4)". CONCLUSIONS: The present work shows a wide spectrum of teaching and research activities and a certain level of evidence for the effectiveness of individual teaching methods. It can be used as orientation and impulse generator for the further development of medical education in the field of PE.

General practitioners' and occupational health physicians' views on their cooperation: a cross-sectional postal survey.

PURPOSE: Prevention, rehabilitation and reintegration into the workplace are examples of overlapping work fields of general practitioners (GPs) and occupational health physicians (OPs). In Germany, however, cooperation between GPs and OPs is often lacking or suboptimal. In this article, we present GPs' and OPs' views on a variety of aspects of their cooperation and differences between them. METHODS: Survey questionnaire was developed on the basis of literature research and results of focus group interviews. Cross-sectional postal survey among GPs (n = 1000) and OPs (n = 383) was performed in the federal state of Baden-Württemberg, Germany. Explorative descriptive and logistic regression analyses were carried out (controlling for potential confounders). RESULTS: Response rates were 31 and 48 %, respectively. Mutual telephone calls were the most frequent contact medium (49 and 91 %, respectively). Both groups considered themselves to have clearly separate areas of responsibility (median = 4, rating scale from 1 "agree not at all" to 5 "agree definitely"). Necessity to cooperate and need to improve cooperation were both rated as 4 (by GPs) and 5 (by OPs), respectively (p < 0.001, Wilcoxon test). Several variables were found to be different by logistic regression analysis of answers from the two groups (e.g. in regard to importance of rehabilitation, primary prevention services, caring for chronically ill workers or changing of workplace conditions). Sensitive topics (e.g. concerning mutual rivalry, remuneration or adherence to medical confidentiality) were also found to be rated differently. CONCLUSION: The data show potential interest of both physicians groups to develop cooperation. As the ratings often differed significantly, particularly in regard to statements presented, answers influenced by social desirability are generally unlikely.

Research tasks as part of the general practice clerkship in undergraduate medical education - a pilot project on feasibility and acceptance.

OBJECTIVE: To assess the integration of a research task performed by students during their two-week clerkship in general practice. METHODS: Students were assigned to interview five patients with coronary heart disease using a standardised questionnaire focusing on potential interaction of medications with statins. Acceptance and feasibility was assessed by means of a questionnaire survey of teaching physicians (n = 20) and students (n = 20). RESULTS: According to most teaching physicians and students the recruitment of patients during the two-week clerkship was possible, and the practice work flow was not disturbed by the project. Both groups considered the research task on the documentation of potential drug interactions with statins as suitable. According to the teaching physicians the project had a learning effect for the students. In contrast, the students graded their learning effect less highly between 'satisfactory' and 'sufficient'. The overall assessment of the project by the students was on average 'satisfactory' and differed from the assessment by the teaching physicians ('good'). CONCLUSIONS: Adequate informing of students and participating physicians about the nature of the project and presenting preliminary results of the data in a plenary session at the end of the clerkship are essential for the acceptance of such projects.

Mechanisms and assessment of statin-related muscular adverse effects.

Statin-associated muscular adverse effects cover a wide range of symptoms, including asymptomatic increase of creatine kinase serum activity and life-threatening rhabdomyolysis. Different underlying pathomechanisms have been proposed. However, a unifying concept of the pathogenesis of statin-related muscular adverse effects has not emerged so far. In this review, we attempt to categorize these mechanisms along three levels. Firstly, among pharmacokinetic factors, it has been shown for some statins that inhibition of cytochrome P450-mediated hepatic biotransformation and hepatic uptake by transporter proteins contribute to an increase of systemic statin concentrations. Secondly, at the myocyte membrane level, cell membrane uptake transporters affect intracellular statin concentrations. Thirdly, at the intracellular level, inhibition of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase results in decreased intracellular concentrations of downstream metabolites (e.g. selenoproteins, ubiquinone, cholesterol) and alteration of gene expression (e.g. ryanodine receptor 3, glycine amidinotransferase). We also review current recommendations for prescribers.

Cooperation between general practitioners and occupational health physicians in Germany: how can it be optimised? A qualitative study.

PURPOSE: General practitioners (GPs) and occupational health physicians (OPs) have several overlapping work fields, such as important functions in prevention, rehabilitation and reintegration into the workplace. In Germany, however, cooperation between GP and OP is often lacking or suboptimal. In this article, we analysed the suggestions for optimisation of cooperation. METHODS: Three focus groups were interviewed: GP, OP and medical doctors working in both fields. A qualitative content analysis was performed. RESULTS: Categories of suggestions could be assigned to five issues: the "Systemic View" concerning the state and/or employer (e.g. the system of remuneration for GPs), "Inter-collegial Contact" (e.g. fostering "friendly exchanges" between both groups), "Medical Education" (e.g. introducing joint quality circles), "Contents of both Specialities" (e.g. necessity of communicating respective contents and competences), and "Patient-centred Care" (e.g. reintegration into workplace after longer periods of illness). The optimisation of cooperation was considered necessary by the OPs, whereas its necessity was sometimes questioned in the GPs' group. CONCLUSION: In many aspects, the present data agree with results of studies from other countries addressing the cooperation between GPs and OPs and/or other specialists. Many suggestions obtained in this study are practical and could be implemented into daily routine. Future quantitative research is required to better assess the relative weight of the suggestions presented here.

A patient with Lyme arthritis presenting in general practice.

Lyme disease, also known as Lyme borreliosis, is caused by infection with Borrelia burgdorferi sensu lato (B. burgdorferi s.l.) complex, a Gram-negative spirochaete bacterium. Infection in humans takes place through tick bites. In principle, Lyme disease may affect every organ of the body and may manifest in different stages. Early localised or disseminated stages are characterised by erythema migrans, lymphadenosis benigna cutis, facial palsy and arthritis and the later stages by arthritis, acrodermatitis chronica atrophicans or encephalomyelitis. The incubation time of the earlier stages varies from several days to months and that of the later stages from weeks to months or even years. Lyme arthritis commonly manifests mono- or oligoarticularly (< 5 joints). Most frequently the knee joint is affected, followed by the ankle, wrist and elbow. The work-up of Lyme arthritis should include a careful history including residence in, or time spent visiting, an endemic region, previous history of tick bite(s), and erythema migrans. In order to confirm a diagnosis of Lyme arthritis clinical findings and specific IgG antibodies are necessary. A lack of IgG antibodies practically rules out Lyme arthritis. Antibodies can be detected even years after infection(s) in asymptomatic individuals with previous Lyme disease treated with antibiotics. In general, the prognosis of Lyme disease is assumed to be good, in particular after antibiotic therapy of early manifestations.

Statin use and its association with musculoskeletal symptoms--a cross-sectional study in primary care settings.

INTRODUCTION: Musculoskeletal complaints are very common in primary care settings. Lipid-lowering drugs are one of several causes of musculoskeletal symptoms. However, data showing an association of lipid-lowering drug therapy and increased odds of musculoskeletal complaints in primary care patients are lacking. OBJECTIVE: To investigate the association between statin use and the reporting of muscular complaints by patients and simultaneously control for several known factors of musculoskeletal complaints. METHODS: In a cross-sectional study with 1031 consecutive patients (>50 years of age) in 26 offices of GPs, two investigators collected the data from the office files and by interviewing the patients. A logistic regression model was used to identify variables affecting the odds of muscular symptoms. RESULTS: The prevalence of lipid-lowering drug prescription was 23% (n = 239) and that of muscular complaints was 40% (n = 411). In all, 44% (n = 106) of the patients with lipid-lowering drug prescription had muscular complaints compared to 39% (n = 305) of the patients without lipid-lowering drug therapy. Statin prescription and 10 variables remained in the final model. Statin prescription is associated with a 1.5-fold odds of musculoskeletal complaints compared to non-prescription {odds ratio [OR] = 1.5 [95% confidence interval (CI), 1.1-2.0], P = 0.02}. CONCLUSION: Having a statin prescription appears to be an independent factor associated with musculoskeletal symptoms in primary care settings. Statin use may be more often associated with musculoskeletal complaints than previously assumed.

Polypharmacy-an Upward Trend with Unpredictable Effects.

BACKGROUND: Guideline-oriented treatments can lead to polypharmacy, i.e., the simultaneous long-term use of multiple drugs. Polypharmacy mainly affects elderly patients. The goal of this review is to survey the current scientific evidence about polypharmacy, focusing on clinical endpoints, and to point out implications for medical practice and research. METHODS: This selective literature review is based on pertinent publications that were retrieved by a selective search in PubMed employing the terms "polypharmacy AND general practice." Selected references were considered as well. RESULTS: In Germany, polypharmacy currently affects approximately 42% of persons over age 65, with an ongoing upward trend. 20-25% of these patients receive potentially inappropriate drugs. Approximately 86% of the daily doses of drugs taken by persons over age 65 are prescribed by general practitioners. There is inconsistent evidence on the question whether polypharmacy affects clinical endpoints such as mortality. It cannot be determined with certainty whether polypharmacy itself, or the underlying multimorbidity, is the reason for worse clinical outcomes. Lists, instruments, and guidelines such as PRISCUS (a list of potentially inappropriate drugs for elderly patients), FORTA (Fit fOR The Aged), MAI (the Medication Appropriateness Index), and the Hausärztliche Leitlinie Multimedikation (a German-language guideline on polypharmacy for general practitioners) can help physicians take care of patients who are taking multiple drugs. It has not yet been proven, however, that their use has any effect on clinical outcomes. CONCLUSION: The decision whether to keep giving a drug or to discontinue it must always be made individually on the basis of current treatment goals; drug lists and a pertinent general practitioners' guideline can be useful aids in decision-making. Efforts to pay more attention to multimorbidity and polypharmacy in future studies and guidelines are deserving of support.

Local anesthetics injection therapy for musculoskeletal disorders: a systematic review and meta-analysis.

OBJECTIVES: Therapeutic injections with local anesthetics (TLA) are widespread and are used for various symptoms of the musculoskeletal system. The aim of the present project was to evaluate the efficacy and safety of TLA in the treatment of musculoskeletal disorders. METHODS: Systematic literature search for controlled clinical trials (Medline, Cochrane, CAMbase, hand search of references) without language limitation; independent screening of the search results (n=3200 hits), abstract reading, and full-text analysis by 2 reviewers. Two authors independently extracted the data and assessed study quality. Meta-analysis was calculated for studies using a continuous scale for pain assessment. RESULTS: Twenty-four controlled trials were included in this review. In almost all studies no primary outcome measure was defined and the overall study quality was low. The qualitative data analysis revealed no clear trend for or against TLA. The meta-analysis of 12 studies showed no significant difference in pain reduction for TLA compared with control treatments consisting of saline injections or other substances, oral analgesics, or nonpharmacological interventions (standardized mean difference -0.31, 95% confidence interval, -0.75 to 0.14). Minor adverse side effects were reported in 7 studies in both the TLA and the control groups with no trend for one of the groups to be safer. DISCUSSION: Despite the widespread use of TLA for musculoskeletal disorders in daily practice, available data are sparse and of low quality and, therefore, do not allow a final recommendation. High-quality studies are needed to close the gap between common practice and research.

[Deficiencies and barriers of the cooperation between German general practitioners and occupational health physicians? A qualitative content analysis of focus groups]. / Die Kooperation zwischen Haus- und Betriebsärzten in Deutschland: Wo befinden sich Defizite und Barrieren?: Eine qualitative Analyse anhand von Fokusgruppeninterviews.

BACKGROUND: Given the high prevalence of work-associated health problems and the significance of work-related stress factors, cooperation between general practitioners (GPs) and occupational health physicians (OPs) is of particular interest to the healthcare system. Both groups of physicians have an important role to play in supporting prevention, rehabilitation and workplace reintegration. In Germany, however, cooperation between GPs and OPs is often lacking or suboptimal. In our study, we assessed relevant deficiencies in and barriers to this cooperation. METHODS: Three focus groups were interviewed: GPs, OPs, and medical doctors working in both fields. Data were analysed according to the qualitative content analysis method of P. Mayring. RESULTS: Deficiencies such as lack of communication (e.g., opportunity to make phone calls), insufficient cooperation in regard to sick-leave and professional reintegration, lack of knowledge about the specialty and influence of OPs as well as about patients' working conditions in general. Barriers: Prejudices, competition, mistrust, fear of negative consequences for the patients, lack of legal regulations, or limited accessibility. DISCUSSION AND CONCLUSIONS: Similar deficiencies and barriers were mentioned in all three focus groups. The data are helpful in understanding the interface between GPs and OPs in Germany to provide an informative basis for the development of quantitative research instruments for further analysis to improve cooperation. This is the basis for additional cooperation projects.

[Which criteria affect the cooperation between general practitioners and specialists in ambulatory care? A qualitative study about general practitioners' perception]. / Welche Kriterien beeinflussen Hausärzte bei der Überweisung zum Spezialisten in der ambulanten Versorgung? Eine qualitative Studie zur Sichtweise von Hausärzten.

BACKGROUND: Good cooperation between physicians is an essential requirement for quality health care. General practitioners (GPs) have a key role in coordinating the various levels of care and physician contacts. Within the scope of the "InteraKtion" study of the Competence Centre of General Practice Baden-Wuerttemberg GPs were interviewed about their experiences and opinions regarding their cooperation with specialists. The aim of this study was to identify criteria and barriers of the referral process. METHODS: 22 semi-structured interviews were conducted among GPs in Heidelberg, Tuebingen and Ulm. Data analysis was carried out using ATLAS.ti according to the qualitative content analysis by P. Mayring. RESULTS: From the GPs' point of view, the criteria for referral to specialists include: specialists' medical skills, good doctor-patient relationship and patient satisfaction. In addition, the willingness to arrange short-term appointments in urgent cases, timely diagnosis and adequate communication were mentioned. The following barriers were pointed out: long appointment wait times and the specialists' increased provision of Individual Healthcare Services. CONCLUSION: These results indicate that GPs have clear criteria for referral to specialists. These findings should find their way into future quantitative studies to explore the weighting of the criteria and barriers discussed here. Joint training activities or quality circles could improve the personal contact between GPs and specialists working in the same region.

Students' performing of practical research tasks for their scientific qualification - an approach within the family practice internship in undergraduate education.

BACKGROUND: Future physicians should be educated in evidence-based medicine. So it is of growing importance for medical students to acquire both practical medical and basic research competencies. However, possibilities and concepts focusing on the acquisition of basic practical research competencies during undergraduate medical studies in Germany are rare. Therefore the aim of this article is to develop a didactic and methodological concept for research-based teaching and learning based on the initial results from the block placement in general practice. METHODS: Connecting medical didactic approaches with classic educational control measures (knowledge, acceptance and transfer evaluation, process evaluation, and outcome evaluation). RESULTS: We describe the steps for implementing a research task into the block placement in general practice. Also stressed is the need to develop didactic material and the introduction of structural changes. Furthermore, these steps are integrated with the individual educational control measures. A summary serves to illustrate the learning and teaching concept (Block Placement Plus). CONCLUSION: The conceptualisation of the Block Placement Plus leads to changes in the daily life routine of medical education during the undergraduate block placement in general practice. The concept can in principle be transferred to other courses. It may serve as an instrument for teachers within the framework of a longitudinal curriculum for the scientific qualification of medical students.

[The stable patient collective as a potential pitfall of prospective primary health-care studies. A qualitative inquiry among general practitioners]. / Der feste Patientenstamm als potentielle Fallgrube prospektiver Studien im primärärztlichen Sektor: Eine qualitative Erhebung unter Studienhausärzten.

BACKGROUND AND PURPOSE: Transparency and disclosure of problems in primary health-care studies can add enormous information to the planning and conduction of such studies. By means of the inquiry of study participants, important data on study problems can be found out. Therefore, the aim of this qualitative study was to identify the causes of unexpected results of an intervention study in general practitioners' (GPs) practices by means of an inquiry of the participating GPs. The very study was about diagnosing alcohol- related health disorders at two points of time 1 year apart each with 2,400 primary health-care patients. METHODS: 39 of the 43 participating GPs of the study mentioned were asked by telephone about the possible causes of the unexpected study results. Data analysis was conducted according to the Qualitative Content Analysis of Philipp Mayring. RESULTS: The GPs mentioned problems that are already described in the international literature: the high expenses for study documentation, tabooed health topics, and declining participation motivation at the end of the study. A further cause of the unexpected study results was picked up: the repeated patient recruitment of this intervention study. It was unclear for the GPs whether they could include the same patients at the first and second recruitment point of time. Moreover, one main reason for the unexpected study results seems to be the stable patient collective of GPs' practices; according to that, only few new patients could be included at the second time point of recruitment. CONCLUSION: In primary health-care research requiring several time points for patient recruitment, one has to consider potential tabooed health topics and the special situation in primary health-care practices. This situation is characterized by a stable amount of known patients, even over years. The here-discussed causes of recruitment problems might be essential to avoid selection bias in primary health-care studies.

[Factors associated with influenza vaccination information--a cross-sectional study in elderly primary care patients]. / Faktoren, die mit Angaben zum Impfschutz gegen Influenza assoziiert sind--eine Querschnittuntersuchung bei älteren hausärztlichen Patienten.

General practitioners (GPs) play an important role in influenza vaccination. However, reliable data on the influenza immunisation coverage rate in primary care patients are quite rare. Due to a lack of personal and time resources general practitioners cannot afford to collect such data by themselves. Hence fifth-year students have been involved in the scientific data collection during their practical placement in 118 GP practices. Using logistic regression analysis of a representative sample (n = 541) plausible factors associated with the influenza immunisation coverage rate have been identified. These factors were found to be both patient- and practice-specific. This practice-oriented study was conducted to improve the available data base on the influenza immunisation coverage rate among elderly patients in primary care settings.