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1.
An integrated modelling approach for targeted degradation: insights on optimization, data requirements and PKPD predictions from semi- or fully-mechanistic models and exact steady state solutions.
J Pharmacokinet Pharmacodyn
; 50(5): 327-349, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37120680
2.
Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging.
Anal Chem
; 90(10): 6051-6058, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29668267
3.
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
J Med Chem
; 66(1): 384-397, 2023 01 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36525250
4.
The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance.
Cancer Res
; 83(23): 3989-4004, 2023 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37725704
5.
Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol.
Pharmacol Res Perspect
; 7(2): e00465, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30899516
6.
Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.
J Med Chem
; 60(7): 3187-3197, 2017 04 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28374589
7.
Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA-Dependent Breast Cancers.
Mol Cancer Ther
; 15(5): 877-89, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26839307
8.
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
J Med Chem
; 55(23): 10610-29, 2012 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23116186
9.
In vivo characterization of Abeta(40) changes in brain and cerebrospinal fluid using the novel gamma-secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the rat.
J Pharmacol Exp Ther
; 317(2): 786-90, 2006 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-16443723
10.
4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 16(2): 280-4, 2006 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16275079
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