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1.
Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range.
Biochemistry
; 62(15): 2289-2300, 2023 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37459182
2.
Pyroglutamate-amyloid-ß and glutaminyl cyclase are colocalized with amyloid-ß in secretory vesicles and undergo activity-dependent, regulated secretion.
Neurodegener Dis
; 14(2): 85-97, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24943989
3.
Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters.
J Biol Chem
; 287(19): 15232-41, 2012 May 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-22393040
4.
Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin.
Extracell Vesicles Circ Nucl Acids
; 4(4): 588-598, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38125374
5.
Dysregulation of Human Juvenile Huntington's Disease Brain Proteomes in Cortex and Putamen Involves Mitochondrial and Neuropeptide Systems.
J Huntingtons Dis
; 12(4): 315-333, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38108356
6.
Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases.
ACS Chem Neurosci
; 13(2): 245-256, 2022 01 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-34986304
7.
Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions.
ACS Omega
; 7(29): 25346-25352, 2022 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35910167
8.
Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons.
ACS Omega
; 6(20): 13033-13056, 2021 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-34056454
9.
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.
ACS Chem Biol
; 16(9): 1628-1643, 2021 09 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34416110
10.
Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication.
J Proteome Res
; 9(10): 5002-24, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20695487
11.
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.
Biochim Biophys Acta Proteins Proteom
; 1868(8): 140428, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32305689
12.
Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration.
J Neurol
; 266(3): 551-564, 2019 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-29956026
13.
Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles.
J Am Soc Mass Spectrom
; 29(5): 935-947, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29556927
14.
Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters.
Peptides
; 46: 126-35, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23747840
15.
Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin.
Endocrine
; 35(3): 429-37, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19343278
16.
Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression.
J Biol Chem
; 283(51): 35652-9, 2008 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-18849346
17.
Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion.
J Biol Chem
; 282(13): 9556-9563, 2007 Mar 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-17244622
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