Relationship Between Body Size and Skeletal Age with Muscle Damage in Young Soccer Players.

This study verified the relationship between body size and skeletal age (SA) with the behavior of blood markers of muscle damage and delayed onset muscle soreness (DOMS) after a soccer match in the U-13 and U-15 categories. The sample consisted of 28 soccer players in the U-13 and 16 in the U-15 categories. Creatine kinase (CK), lactate dehydrogenase (LDH), and DOMS were evaluated up to 72 h after the match. Muscle damage was elevated at 0 h in U-13, and from 0 h to 24 h in U-15. DOMS increased from 0 h to 72 h in U-13 and from 0 h to 48 h in U-15. Significant associations of SA and fat-free mass (FFM) with muscle damage markers and DOMS were observed only in U-13, specifically at time 0 h, when SA explained 56% of CK and 48% of DOMS and FFM explained 48% of DOMS. We concluded that in the U-13 category, higher SA is significantly associated with muscle damage markers, and increase in FFM is associated with muscle damage markers and DOMS. Furthermore, U-13 players need 24 h to recover pre-match muscle damage markers and more than 72 h to recover DOMS. In contrast, the U-15 category needs 48 h to recover muscle damage markers and 72 h to recover DOMS.

Simple and reliable protocol for identifying talented junior players in team sports using small-sided games.

We designed and tested a protocol for measuring the performance of individuals in small-sided soccer games. We tested our protocol on three different groups of youth players from elite Brazilian football academies. Players in each group played a series of 3v3 games, in which individuals were randomly assigned into new teams and against new opponents for each game. We calculated each individual's average individual goals scored, goals scored by teammates, goals conceded, and net team goals per game. Our protocol was consistent across days and repeatable across groups, with intraclass correlation coefficients (ICCs) of 0.57-0.69 for average net goals per game across testing days. Players could achieve high success by scoring goals or ensuring their team concede few goals. We also calculated the first and second dimension of a principal component analysis based on each player's number of goals scored, goals scored by teammates, and number of goals conceded per game. Players that were overall high performers had higher PC1 scores, while PC2 scores represented the type of contribution made by a player to overall performance. Positive PC2 values were indicative of high number of individual goals while negative values were associated with more goals from teammates and fewer conceded goals. Our design allows coaches and scouts to easily collect a robust metric of individual performance using randomly designed, small-sided games. We also provide simulations that allow one to apply our methodology for individual talent identification to other small-sided games in any team sport.

Non-radiographic validity and reliability measures for assessing foot types: A systematic review.

BACKGROUND: Foot type classification is well recognized in clinical practice and orthopedic literature, a universally accepted classification or standardized measures to determine foot types are lacking. The objective of this study was to identify which non-radiographic assessment methods are considered valid and/or reliable for the classification of foot types. METHOD: A systematic database search was performed. Only cross-sectional studies that performed reliability and/or validity analysis of non-radiographic methods were included. To evaluate the risk of bias, the Critical Appraisal Tool (CAT) was used to evaluate the measurement properties of objective clinical methods. RESULTS: Twenty-six studies were included. The results of reliability and validity, in general, demonstrated high scores, but, inconsistencies were related to the variability of the measurements, heterogeneity of the methods used to determine reliability and validity, and lack of parameters for classifying foot types, which resulted in few elements to determine which method of foot type evaluation is valid and reliable. CONCLUSION: Given the Intraclass Correlation Coefficient and CAT results and the presence of normative values, the static measurements of the "Arch Height Index", "Foot Posture Index", and "Staheli Arch Index" can be suggested to classify foot types.

Team Dynamics, Running, and Skill-Related Performances of Brazilian U11 to Professional Soccer Players During Official Matches.

Palucci Vieira, LH, Aquino, R, Moura, FA, Barros, RMLd, Arpini, VM, Oliveira, LdP, Bedo, BLdS, and Pereira Santiago, PR. Team dynamics, running, and skill-related performances of Brazilian U11 to professional soccer players during official matches. J Strength Cond Res 33(8): 2202-2216, 2019-Analyses of movements during soccer competition have been used previously to help develop conditioning programs. However, this has not been extensively studied in youth populations. Therefore, the purposes of this study were to examine (1) dynamics of collective tactical movements, (2) running, and (3) skill-related performances during soccer matches disputed by children to senior players. A total of 120 Brazilian players in the age groups U11, U13, U15, U17, U20, and professional (PRO) were monitored during official competition matches (N = 12). Using semiautomatic video-based tracking (30 Hz), match running variables including total distance traveled, average speed, maximum sprint speed, and high-intensity activities were evaluated. Tactical metrics were computed as team surface area, spread, and median frequency. Through notational analysis, technical skills such as involvements with the ball, passes, ball touches, duels, and goal attempts were also recorded. One-way analysis of variance and magnitude-based inferences were used to detect differences between ages. Although the average speed, team surface area, and spread tended to present stabilized increases from the U15 (e.g., U15 > U13 > U11), maximal sprinting speed (PRO > U17 > U15, U13, U11) and percentage at very high-intensity activities (U20 > PRO, U17 > U15 > U13 > U11) demonstrated continuous gains. Median frequencies were higher in the younger groups (U13, U15, U17 > U20, PRO), although the percentage of successful passes was higher in the older groups (PRO > U17, U15 > U13, U11). We concluded that Brazilian U11 to PRO players present different performance profiles for running, collective movement dynamics, and technical skills, and that the rate of development regarding these components varies. Coaches should be aware of these differences to select and adapt training content for each age group.

Repeated-Sprint Sequences During Female Soccer Matches Using Fixed and Individual Speed Thresholds.

Nakamura, FY, Pereira, LA, Loturco, I, Rosseti, M, Moura, FA, and Bradley, PS. Repeated-sprint sequences during female soccer matches using fixed and individual speed thresholds. J Strength Cond Res 31(7): 1802-1810, 2017-The main objective of this study was to characterize the occurrence of single sprint and repeated-sprint sequences (RSS) during elite female soccer matches, using fixed (20 km·h) and individually based speed thresholds (>90% of the mean speed from a 20-m sprint test). Eleven elite female soccer players from the same team participated in the study. All players performed a 20-m linear sprint test, and were assessed in up to 10 official matches using Global Positioning System technology. Magnitude-based inferences were used to test for meaningful differences. Results revealed that irrespective of adopting fixed or individual speed thresholds, female players produced only a few RSS during matches (2.3 ± 2.4 sequences using the fixed threshold and 3.3 ± 3.0 sequences using the individually based threshold), with most sequences composing of just 2 sprints. Additionally, central defenders performed fewer sprints (10.2 ± 4.1) than other positions (fullbacks: 28.1 ± 5.5; midfielders: 21.9 ± 10.5; forwards: 31.9 ± 11.1; with the differences being likely to almost certainly associated with effect sizes ranging from 1.65 to 2.72), and sprinting ability declined in the second half. The data do not support the notion that RSS occurs frequently during soccer matches in female players, irrespective of using fixed or individual speed thresholds to define sprint occurrence. However, repeated-sprint ability development cannot be ruled out from soccer training programs because of its association with match-related performance.

Comparing three generic musculoskeletal models to estimate the tibiofemoral reaction forces during gait and sit-to-stand tasks.

The choice of musculoskeletal (MSK) model is crucial for performing MSK estimations to evaluate muscle demands and joint forces. This study compared two previously published generic MSK models and a modified model to estimate tibiofemoral reaction forces (TFRF) during gait, sit-to-stand, and stand-to-sit. The estimated tibiofemoral reaction forces were compared with an in vivo dataset from six patients using an instrumented knee prosthesis. A correlation and root mean square error (RMSE) in the time-series analysis and relative peak error (RPE) were evaluated. The results showed that the three MSK models were similar in estimating the vertical forces, with a large correlation, and RPE was found around 20 % during gait. The RMSE and the RPE indicated that the modified model had lower total and lateral compartment forces errors for sit-to-stand and stand-to-sit, showing the best performance. The shear forces for all tasks and models showed significant errors. Future MSK studies should consider these findings when researching functional tasks. The modified model was found to be more effective in estimating the vertical tibiofemoral joint reaction forces in tasks that impose greater demands on muscle forces and require high knee and hip flexion.

Using Social Network Analysis to Study Relationships Between Young Soccer Players' Bone Age, Body Size, and the Centrality of Their Pass Interactions.

Prior research has suggested relevance to anthropometric variance of youth athletes at various stages of their maturation, and prior studies of youth players' soccer skills have failed to consider their interdependent interactions during play. Accordingly, to address both of these separate research omissions, we aimed in this study to analyze the relationships between young (U-13 and U-15 groups) soccer players' bone age and body size indicators and centrality measures of their pass interactions during small sided games. We included young 81 athletes (M age = 14.4, SD = 1.1 years) from whom we took anthropometric measurements of body mass, height, and trunk-cephalic height and obtained their bone age using the Tanner-Whitehouse 3 classification method. We also filmed small-sided games in the goal keeper/three player (GK3-3GK) format to analyze the centrality of their passing actions on the following measures: degree of centrality, closeness of centrality, degree of prestige, and proximity of prestige. There were no group differences in the prominence of passing actions across these three measures (tmean = -3.13; p > .05). Canonical correlations of these relationships were significant only in the U-13 group, in which centrality in passing actions was related to body size (r = 0.71; R2 = 0.21; ʌ = 0.28; p = .03). U-13 players who were physically larger and who presented higher bone age showed centralized main passing actions.

Lower limb inter-joint coordination in individuals with osteoarthritis before and after a total knee arthroplasty.

BACKGROUND: Total knee arthroplasty is the most common treatment for severe knee osteoarthritis. Coordination and variability analyses are effective measures of the injury stage or rehabilitation process. This study compared the inter-joint coordination before and after arthroplasty, compared to controls. METHODS: Twenty-seven patients were evaluated before and 12 months after surgery, compared to 27 controls. Coordination and variability in the sagittal plane between the hip-knee and knee-ankle were calculated using vector coding and circular statistics. Coordination was categorized as in-phase, anti-phase, or distal or proximal joint-phase. The gait cycle was divided into sub-phases for the coordination, variability, and range of motion results. FINDINGS: Coordination and range of motion differed significantly between the patient groups and controls, while small differences between pre- and post-operative groups were also detected. The hip-knee showed a reduced in-phase frequency in the patient group compared to control during stance, particularly mid-stance: pre-operative 24.3% ± 33.9, post-operative 29.5 ± 29.7, and controls 70.7 ± 17.0. This difference was compensated for by increasing proximal-phase (hip) frequency in the patient groups. For knee-ankle coordination, the patient groups showed higher distal-phase (ankle) frequency during the early and mid-stance. Coordination variability was higher post-operatively during swing and terminal swing phases, compared to controls. INTERPRETATION: The results indicated reduced degrees of freedom for the knee during stance phase with a reduced capacity to move the knee and hip in opposing directions before and one year after surgery. The patient group after the surgery increased knee range of motion and coordination compared to pre-operative during swing phase.

Classification and determinants of passing difficulty in soccer: a multivariate approach.

INTRODUCTION: Usually, the players' or teams' efficiency to perform passes is measured in terms of accuracy. The degree of difficulty of this action has been overlooked in the literature. OBJECTIVES: The present study aimed to classify the degree of passing difficulty in soccer matches and to identify and to discuss the variables that most explain the passing difficulty using spatiotemporal data. RESULTS: The data used corresponds to 2,856 passes and 32 independent variables. The Fisher Discriminant Analysis presented 72.0% of the original grouped cases classified correctly. The passes analyzed were classified as low (56.5%), medium (22.6%), and high difficulty (20.9%), and we identified 16 variables that best explain the degree of passing difficulty related to the passing receiver, ball trajectory, pitch position and passing player. CONCLUSIONS: The merit and ability of the player to perform passes with high difficulty should be valued and can be used to rank the best players and teams.In addition, the highlighted variables should be looked carefully by coaches when analyzing profiles, strengths and weaknesses of players and teams, and talent identification context. PRACTICAL IMPLICATIONS: The values found for each variable can be used as a reference for planning training, such as small side games, and in future research.

Effect of running exercise on titanium dioxide (TiO2)-induced chronic arthritis and sarcopenia in mice. A titanium prosthesis loosening injury model study.

AIMS: This study aimed to investigate if titanium dioxide (TiO2) joint administration is a useful pre-clinical model to study sarcopenia-related chronic arthritis, and if exercise is a useful therapeutic approach against the pathogenesis of TiO2-induced arthritis and sarcopenia in mice. MAIN METHODS: Two experiments were conducted. Firstly, 36 female Swiss mice were randomly divided into a control group (n = 12) and two groups who received intra-articular TiO2 injections of 0.3-mg (n = 12) and 3-mg (n = 12), respectively. Mice were euthanized 4 and 8 weeks after TiO2 injections. Based on data of the first experiment, mice were exposed to four groups: control (C, n = 10), exercised (Ex, n = 10), injected with 3-mg of TiO2 (TiO2, n = 10), and injected with 3-mg of TiO2 and exercised (TiO2 + Ex, n = 10) for a total of 8-weeks. KEY FINDINGS: Eight-week of 3 mg of TiO2 joint administration promoted characteristics of chronic inflammation such as elevated histopathological score, inflammation, edema and pain. Hallmarks of sarcopenia were also observed such as muscle atrophy and loss of strength. Furthermore, voluntary exercise running reduced TiO2-induced chronic inflammation and pain, attenuating chronic arthritis-related muscle atrophy, strength loss and impairment of locomotion capacity. In addition, exercise was also able to prevent TiO2-induced collagen degradation, an important marker of functional and structural integrity loss of cartilage and chronic arthritis disease progression. SIGNIFICANCE: TiO2 joint administration mimed titanium prosthesis release-induced joint chronic arthritis and sarcopenia-related chronic arthritis, disturbances that were attenuated by voluntary exercise.

Age- and size-corrected kicking speed and accuracy in elite junior soccer players.

Kicking powerfully and accurately is essential in soccer, and players who kick proficiently with both feet are highly sought after. Assessing performance in youth players is often confounded by more physically developed players outperforming their smaller peers. To alleviate such bias, we present a testing protocol and normative data developed with an elite Brazilian soccer academy that controls for players' age and size to assess kick performance with both feet. We measured kick speed and kick accuracy of 178 players and recorded their age (10-20 years), height, and mass. Combining age, height, and mass into an age and size index (ASI), we developed equations describing the relationship between ASI and performance. To determine the underlying predictors of performance, we also measured sprint ability and soccer-specific motor control of each foot with ball dribbling tasks. Kicking speed with the dominant foot was predicted by ASI, sprint speed, and motor control of the nondominant foot, while kicking speed with the nondominant foot was predicted by ASI and motor control of the nondominant foot. Kick accuracy with each foot was predicted by ASI and motor control of the corresponding foot. To improve kicking performance, we suggest training programs focus on motor control.

Influence of the medial longitudinal arch of the foot in adult women in ankle isokinetic performance: a cross-sectional study.

BACKGROUND: Maintenance of the medial longitudinal arch (MLA) of the foot is fundamental during functional tasks and disorders can lead to clinical alterations. Studies have demonstrated that deficits in ankle isokinetic performance can predispose an individual to lower limb injuries. OBJECTIVES: To evaluate the muscular performance of cavus, planus, and normal feet by means of torque/body mass and the isokinetic phases, to generate 3D surface map analysis, and to verify whether there is a relationship between MLA height and arch height flexibility with isokinetic performance. METHODS: The sample consisted of 105 healthy adult women, divided into three groups: normal, cavus, and planus. Assessment in concentric mode at 30, 60, and 90 °/s in the dorsiflexion and plantarflexion of the ankle joint were analyzed during the three isokinetic phases (acceleration, sustained velocity, and deceleration). The variables total range of motion, peak of torque (PT), and angle of PT were extracted within the sustained velocity. RESULTS: In dorsiflexion at 60 °/s, the phase where the velocicty is sustained (load range phase) was higher in the planus group (MeanDifference=10.9 %; ω2p = 0.06) when compared with the cavus group. Deficits in the peak torque/body mass in dorsiflexion at 60 °/s (cavus feet: MD=-3 N.m/kg; ω2p = 0.06; and planus feet: MD=-1.1 N.m/kg; ω2p = 0.06) were also observed as well as in the 3D surface maps, when compared with the normal group. The flexibility of MLA had a negative correlation of PT at 30 °/s in cavus group. The heigth of MLA had a postive correlation with the PT for the cavus and planus group ate 60 °/s. All other results did not show differences between the groups. CONCLUSIONS: The planus groups showed a better capacity of attain and sustained the velocity in dorsiflexion in relation the cavus group. The cavus and planus group had deficts in torque in relation the normal. The correlations were weak between the measures of MLA and PT. Thereby, in general the differences between foot types showed small effect in isokinetic muscle performance measures of the plantar and dorsi flexores. TRIAL REGISTRATION: Study design was approved by the IRB (#90238618.8.0000.5231).

Low back pain affects coordination between the trunk segments but not variability during running.

This study aimed to analyze the coordination and variability between the thorax, lumbar, and pelvis segments in runners with chronic low back pain group (LBPG) and matched control group (CG). Twenty-six recreational runners were evaluated on a treadmill at 3.3 m/s. The coordination of the pelvis-lumbar and lumbar-thorax in all three planes and between the transverse and frontal plane of the lumbar segment were evaluated using the vector coding technique. Coordination was analyzed via histograms with the percentage of each pattern and the coupling angle during the cycle. The variability coordination was calculated from the angular deviation between the cycles. Differences were observed in the coordination patterns and in the coupling angle during the cycle. Between the pelvis-lumbar in the frontal plane, the LBPG (x¯ = 50.6% (SD = 10.7)) presented more in-phase pattern than the CG (38.6% (8.7; P = 0.05). For the lumbar-thorax, differences occurred in all planes. Between the frontal-transverse plane of the lumbar segment, the LBPG (27.6% (7.9)) presented more in-phase pattern than the CG (38.6% (8.7); P = 0.02). The variability did not demonstrate the differences between the groups; these differences were observed in coordination between the lumbar and adjacent segments in all planes. The model of rigid segments and the coordination analyses were sensitive to detect these differences, and the presence of more in-phase patterns could be related to the protection mechanism in order to avoid painful movements.

Test-retest reliability of multiscale fractal dimension measurements of plantar pressure maps during dynamic tasks.

The tools used to evaluate foot types are divergent since they adopt classic linear analyzes, based on anthropometric or image measurements, which do not dynamically contemplate the variability of foot shape. The use of newer techniques such as multiscale fractal dimension (MFD) may be a key to this type of problem. However, for these measures to be used safely and consistently, it is essential to evaluate their reliability. The aim of this study was to evaluate the test-retest reliability of MFD measurements of adult plantar pressure maps during gait, as well as the standard error of measurement (SEM), and minimal detectable change (MDC90). Seventy-two subjects were included in the test-retest, with a one week interval. The plantar pressure maps were constructed using a pressure platform. The data were processed in a routine for extracting the MFD curve measurements (maximum and integral values). The Intraclass Correlation Coefficient results (ICC3,k) were excellent for both measurements (maximum value 0.96, 95% confidence interval [0.93-0.97], and integral 0.95 [0.92-0.97]) with low SEM and MDC90 values below 10% of the mean. The application of MFD to the plantar pressure data generated by the pressure platform is reliable and could allow exploration of the complexity of foot shapes, enabling their classification.

Velocity-specific knee strength between professional and under-17 female volleyball players.

BACKGROUND: Many studies have investigated isokinetic performance in volleyball players but not through surface maps. OBJECTIVES: The goals of this study were to assess velocity-specific isokinetic knee extensor-flexor muscle strength and to compare the isokinetic knee extensor-flexor muscles between professional (PRO) and under-17 (U17) female volleyball players. METHOD: This cross-sectional laboratory study was developed with two groups: PRO (n = 12), medianage = 21.3 years, and U17 (n = 9), medianage = 15 years. Peak torque, total work, mean power, angle of peak torque, hamstring-quadriceps torque ratio (H-Q ratio) and torque-angle-velocity surface maps were analysed from knee extension-flexion at 60, 120 and 300 degrees per second (°/s). RESULTS: Significant differences were identified for extensor peak torque between PRO x = 202.3 Newton metre (N·m) (standard deviation [SD] = 24.4) and U17 x = 141.6 N·m (30.1) at 60 °/s (p < 0.001; d = 2.21) as well as flexor peak torque (PRO x = 75.7 N·m [10.3] and U17 x = 57.7 N·m [11.4]) at 120 °/s (p < 0.001; d = 1.65) for the dominant limb. There were also significant group differences for total work and mean power at all velocities for extension and flexion. Surface maps demonstrated higher torque at lower speeds for both groups with smaller torque changes across velocities for flexion. CONCLUSION: Different groups of female volleyball players showed contrasting concentric knee muscle strength across isokinetic velocities. CLINICAL IMPLICATIONS: These results demonstrate the importance of specific strength training for different age groups, even within the same sport, and provide insight into muscle strength.

ISOKINETIC MUSCLE PERFORMANCE AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION: A CASE-CONTROL STUDY.

BACKGROUND: and Purpose: Knee muscle strength deficits have been reported in individuals who have undergone anterior cruciate ligament reconstruction (ACLR). Isokinetic testing is a valid way to assess muscle strength. Some isokinetic variables, including the range of motion in the phases to attain a specific velocity, load range (sustained specific velocity), time to achieve deceleration, and qualitative analysis of the torque-angle velocity relationship, may contribute to understanding recovery of these individuals after surgery. Thus, the purpose of this study was to compare the load range (LR), time to attain velocity (TTAV), deceleration time (DT) phases, total range of motion (ROM), peak torque/body mass (PT/BM), angle of peak torque (AngPT) during LR and torque-angle-velocity relationships (TAV3D) between post ACLR and matched control subjects.Study design: Case-control. METHODS: Seven men who underwent ACLR and seven matched controls were evaluated from four to six months after surgery. Testing was performed on a Biodex System 4 isokinetic dynamometer in concentric mode at 60, 120 and 300 °/s, for knee flexion and extension. RESULTS: Statistically significant differences were seen for extension ROM at 60 °/s where ROM was greater in the control group. PT/BM for extensors was also significantly greater in controls by 20 % compared to ACLR at 60 and 120 °/s. PT/BM for flexors was significantly greater for controls at 60 °/s (∼15 %). TAV3D showed differences in torque and, specifically, the control group sustained knee flexion torque for a greater range of motion when compared to the ACLR group. CONCLUSION: The ACL group presented with lower ROM and PT/BM, therefore exhibiting worse muscle performance in comparison to the control group.Level of Evidence: 3.

Analysis of the distances covered by first division brazilian soccer players obtained with an automatic tracking method.

Methods based on visual estimation still is the most widely used analysis of the distances that is covered by soccer players during matches, and most description available in the literature were obtained using such an approach. Recently, systems based on computer vision techniques have appeared and the very first results are available for comparisons. The aim of the present study was to analyse the distances covered by Brazilian soccer players and compare the results to the European players', both data measured by automatic tracking system. Four regular Brazilian First Division Championship matches between different teams were filmed. Applying a previously developed automatic tracking system (DVideo, Campinas, Brazil), the results of 55 outline players participated in the whole game (n = 55) are presented. The results of mean distances covered, standard deviations (s) and coefficient of variation (cv) after 90 minutes were 10,012 m, s = 1,024 m and cv = 10.2%, respectively. The results of three-way ANOVA according to playing positions, showed that the distances covered by external defender (10642 ± 663 m), central midfielders (10476 ± 702 m) and external midfielders (10598 ± 890 m) were greater than forwards (9612 ± 772 m) and forwards covered greater distances than central defenders (9029 ± 860 m). The greater distances were covered in standing, walking, or jogging, 5537 ± 263 m, followed by moderate-speed running, 1731 ± 399 m; low speed running, 1615 ± 351 m; high-speed running, 691 ± 190 m and sprinting, 437 ± 171 m. Mean distance covered in the first half was 5,173 m (s = 394 m, cv = 7.6%) highly significant greater (p < 0.001) than the mean value 4,808 m (s = 375 m, cv = 7.8%) in the second half. A minute-by-minute analysis revealed that after eight minutes of the second half, player performance has already decreased and this reduction is maintained throughout the second half. Key pointsA novel automatic tracking method was presented. No previous work was found in the literature reporting data of simultaneous trajectories of all soccer players obtained by an automatic tracking method.The study reveals 7% reduction in mean distance covered in the second half and moreover after eight minutes of the second half, player performance has already decreased and this reduction is maintained throughout the second half.

Syngeneic B16F10 Melanoma Causes Cachexia and Impaired Skeletal Muscle Strength and Locomotor Activity in Mice.

Muscle wasting has been emerging as one of the principal components of cancer cachexia, leading to progressive impairment of work capacity. Despite early stages melanomas rarely promotes weight loss, the appearance of metastatic and/or solid tumor melanoma can leads to cachexia development. Here, we investigated the B16F10 tumor-induced cachexia and its contribution to muscle strength and locomotor-like activity impairment. C57BL/6 mice were subcutaneously injected with 5 × 104 B16F10 melanoma cells or PBS as a Sham negative control. Tumor growth was monitored during a period of 28 days. Compared to Sham mice, tumor group depicts a loss of skeletal muscle, as well as significantly reduced muscle grip strength and epididymal fat mass. This data are in agreement with mild to severe catabolic host response promoted by elevated serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and lactate dehydrogenase (LDH) activity. Tumor implantation has also compromised general locomotor activity and decreased exploratory behavior. Likewise, muscle loss, and elevated inflammatory interleukin were associated to muscle strength loss and locomotor activity impairment. In conclusion, our data demonstrated that subcutaneous B16F10 melanoma tumor-driven catabolic state in response to a pro-inflammatory environment that is associated with impaired skeletal muscle strength and decreased locomotor activity in tumor-bearing mice.