Detalles de la búsqueda
1.
Comprehensive stability analysis of 13 ß-lactams and ß-lactamase inhibitors in in vitro media, and novel supplement dosing strategy to mitigate thermal drug degradation.
Antimicrob Agents Chemother
; 68(3): e0139923, 2024 Mar 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38329330
2.
Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology.
Antimicrob Agents Chemother
; 67(6): e0160322, 2023 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37199612
3.
Comparative analysis of in vitro dynamics and mechanisms of ceftolozane/tazobactam and imipenem/relebactam resistance development in Pseudomonas aeruginosa XDR high-risk clones.
J Antimicrob Chemother
; 77(4): 957-968, 2022 03 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-35084040
4.
In vitro evolution of cefepime/zidebactam (WCK 5222) resistance in Pseudomonas aeruginosa: dynamics, mechanisms, fitness trade-off and impact on in vivo efficacy.
J Antimicrob Chemother
; 76(10): 2546-2557, 2021 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34219168
5.
Molecular Basis of AmpC ß-Lactamase Induction by Avibactam in Pseudomonas aeruginosa: PBP Occupancy, Live Cell Binding Dynamics and Impact on Resistant Clinical Isolates Harboring PDC-X Variants.
Int J Mol Sci
; 22(6)2021 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33802668
6.
First Penicillin-Binding Protein Occupancy Patterns for 15 ß-Lactams and ß-Lactamase Inhibitors in Mycobacterium abscessus.
Antimicrob Agents Chemother
; 65(1)2020 12 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-33106266
7.
Effective inhibition of PBPs by cefepime and zidebactam in the presence of VIM-1 drives potent bactericidal activity against MBL-expressing Pseudomonas aeruginosa.
J Antimicrob Chemother
; 75(6): 1474-1478, 2020 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32083659
8.
In vitro dynamics and mechanisms of resistance development to imipenem and imipenem/relebactam in Pseudomonas aeruginosa.
J Antimicrob Chemother
; 75(9): 2508-2515, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32514525
9.
In Vitro and In Vivo Activities of ß-Lactams in Combination with the Novel ß-Lactam Enhancers Zidebactam and WCK 5153 against Multidrug-Resistant Metallo-ß-Lactamase-Producing Klebsiella pneumoniae.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30782985
10.
Comparable Efficacy and Better Safety of Double ß-Lactam Combination Therapy versus ßLactam plus Aminoglycoside in Gram-Negative Bacteria in Randomized, Controlled Trials.
Antimicrob Agents Chemother
; 63(7)2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30988147
11.
First Penicillin-Binding Protein Occupancy Patterns of ß-Lactams and ß-Lactamase Inhibitors in Klebsiella pneumoniae.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29712652
12.
WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "ß-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-ß-Lactamase-Producing High-Risk Clones.
Antimicrob Agents Chemother
; 61(6)2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28289035
13.
Potent ß-Lactam Enhancer Activity of Zidebactam and WCK 5153 against Acinetobacter baumannii, Including Carbapenemase-Producing Clinical Isolates.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28848013
14.
Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates.
Antimicrob Agents Chemother
; 60(3): 1767-78, 2016 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26729493
15.
Sequential Treatment of Biofilms with Aztreonam and Tobramycin Is a Novel Strategy for Combating Pseudomonas aeruginosa Chronic Respiratory Infections.
Antimicrob Agents Chemother
; 60(5): 2912-22, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26926631
16.
Deciphering the Resistome of the Widespread Pseudomonas aeruginosa Sequence Type 175 International High-Risk Clone through Whole-Genome Sequencing.
Antimicrob Agents Chemother
; 60(12): 7415-7423, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27736752
17.
Role of Pseudomonas aeruginosa low-molecular-mass penicillin-binding proteins in AmpC expression, ß-lactam resistance, and peptidoglycan structure.
Antimicrob Agents Chemother
; 59(7): 3925-34, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25896695
18.
Overexpression of MexCD-OprJ reduces Pseudomonas aeruginosa virulence by increasing its susceptibility to complement-mediated killing.
Antimicrob Agents Chemother
; 58(4): 2426-9, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24419345
19.
The Pseudomonas aeruginosa CreBC two-component system plays a major role in the response to ß-lactams, fitness, biofilm growth, and global regulation.
Antimicrob Agents Chemother
; 58(9): 5084-95, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24936599
20.
Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC.
Antimicrob Agents Chemother
; 58(6): 3091-9, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24637685