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1.
Proc Natl Acad Sci U S A ; 109(45): 18493-8, 2012 Nov 06.
Artículo en Inglés | MEDLINE | ID: mdl-23091028

RESUMEN

The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes responsible for A and B specificity in all species sequenced to date. Whether this recurrence of A and B antigens is the result of an ancient polymorphism maintained across species or due to numerous, more recent instances of convergent evolution has been debated for decades, with a current consensus in support of convergent evolution. We show instead that genetic variation data in humans and gibbons as well as in Old World monkeys are inconsistent with a model of convergent evolution and support the hypothesis of an ancient, multiallelic polymorphism of which some alleles are shared by descent among species. These results demonstrate that the A and B blood groups result from a trans-species polymorphism among distantly related species and has remained under balancing selection for tens of millions of years-to date, the only such example in hominoids and Old World monkeys outside of the major histocompatibility complex.


Asunto(s)
Sistema del Grupo Sanguíneo ABO/genética , Polimorfismo Genético , Primates/genética , Alelos , Animales , Cercopithecidae/genética , Evolución Molecular , Exones/genética , Genotipo , Modelos Genéticos , Datos de Secuencia Molecular , Fenotipo , Filogenia , Especificidad de la Especie
2.
Zoo Biol ; 30(4): 427-44, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-20853409

RESUMEN

Blood groups of humans and great apes have long been considered similar, although they are not interchangeable between species. In this study, human monoclonal antibody technology was used to assign human ABO blood groups to whole blood samples from great apes housed in North American and European zoos and in situ managed populations, as a practical means to assist blood transfusion situations for these species. From a subset of each of the species (bonobo, common chimpanzee, gorilla, and orangutans), DNA sequence analysis was performed to determine blood group genotype. Bonobo and common chimpanzee populations were predominantly group A, which concurred with historic literature and was confirmed by genotyping. In agreement with historic literature, a smaller number of the common chimpanzees sampled were group O, although this O blood group was more often present in wild-origin animals as compared with zoo-born animals. Gorilla blood groups were inconclusive by monoclonal antibody techniques, and genetic studies were inconsistent with any known human blood group. As the genus and, specifically, the Bornean species, orangutans were identified with all human blood groups, including O, which had not been reported previously. Following this study, it was concluded that blood groups of bonobo, common chimpanzees, and some orangutans can be reliably assessed by human monoclonal antibody technology. However, this technique was not reliable for gorilla or orangutans other than those with blood group A. Even in those species with reliable blood group detection, blood transfusion preparation must include cross-matching to minimize adverse reactions for the patient.


Asunto(s)
Hominidae/sangre , Animales , Animales Salvajes , Animales de Zoológico , Antígenos de Grupos Sanguíneos , ADN/genética , Especies en Peligro de Extinción , Genotipo , Hominidae/genética , Reproducibilidad de los Resultados , Especificidad de la Especie
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