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Eur J Immunol ; 54(6): e2350771, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38494423

RESUMEN

Vomocytosis, also known as nonlytic exocytosis, is a process whereby fully phagocytosed microbes are expelled from phagocytes without discernible damage to either the phagocyte or microbe. Although this phenomenon was first described in the opportunistic fungal pathogen Cryptococcus neoformans in 2006, to date, mechanistic studies have been hampered by an inability to reliably stimulate or inhibit vomocytosis. Here we present the fortuitous discovery that macrophages lacking the scavenger receptor MAcrophage Receptor with COllagenous domain (MARCO), exhibit near-total vomocytosis of internalised cryptococci within a few hours of infection. Marco-/- macrophages also showed elevated vomocytosis of a yeast-locked C. albicans strain, suggesting this to be a broadly relevant observation. We go on to show that MARCO's role in modulating vomocytosis is independent of its role as a phagocytic receptor, suggesting that this protein may play an important and hitherto unrecognised role in modulating macrophage behaviour.


Asunto(s)
Cryptococcus neoformans , Macrófagos , Receptores Inmunológicos , Animales , Ratones , Cryptococcus neoformans/inmunología , Macrófagos/inmunología , Macrófagos/microbiología , Receptores Inmunológicos/metabolismo , Receptores Inmunológicos/inmunología , Receptores Inmunológicos/genética , Candida albicans/inmunología , Fagocitosis/inmunología , Ratones Noqueados , Exocitosis/inmunología , Criptococosis/inmunología
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